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公开(公告)号：US07047708B2
公开(公告)日：2006-05-23
申请号：US10735639
申请日：2003-12-16
申请人： Katsuhiro Inada , Mitsuhira Nishio , Yoshiyuki Kimura , Junji Kaga , Koichi Muraoka , Nobuaki Sumiyoshi , Seiichiro Iguchi , Hiroaki Yamamoto
发明人： Katsuhiro Inada , Mitsuhira Nishio , Yoshiyuki Kimura , Junji Kaga , Koichi Muraoka , Nobuaki Sumiyoshi , Seiichiro Iguchi , Hiroaki Yamamoto
CPC分类号： A61J1/10 , A61F9/007 , A61J1/1462 , A61J1/16 , A61J1/2024 , A61J1/2093
摘要： A packaged ocular irrigating solution bag, which comprises a gas-permeable plastic multiple compartment bag and a gas-impermeable plastic packaging member for packaging the bag and in which an oxiglutatione-containing solution or solid preparation is enclosed in one compartment and a bicarbonate ion solution is enclosed in another compartment and the space between the bag and the packaging member has a carbon dioxide gas atmosphere.
摘要翻译： 一种包装的眼睛冲洗溶液袋，其包括透气塑料多隔层袋和用于包装袋的气体不可渗透的塑料包装构件，其中将含氧化引发剂的溶液或固体制剂封闭在一个隔室中，并且碳酸氢根离子溶液 被封闭在另一个隔间中，并且袋和包装构件之间的空间具有二氧化碳气体气氛。
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公开(公告)号：US06764481B1
公开(公告)日：2004-07-20
申请号：US09530507
申请日：2000-04-27
申请人： Katsuhiro Inada , Mitsuhira Nishio , Yoshiyuki Kimura , Junji Kaga , Koichi Muraoka , Nobuaki Sumiyoshi , Seiichiro Iguchi , Hiroaki Yamamoto
发明人： Katsuhiro Inada , Mitsuhira Nishio , Yoshiyuki Kimura , Junji Kaga , Koichi Muraoka , Nobuaki Sumiyoshi , Seiichiro Iguchi , Hiroaki Yamamoto
IPC分类号： A61B1900
CPC分类号： A61J1/10 , A61F9/007 , A61J1/1462 , A61J1/16 , A61J1/2024 , A61J1/2093
摘要： A packaged ocular irrigating solution bag, which comprises a gas-permeable plastic multiple compartment bag and a gas-impermeable plastic packaging member for packaging the bag and in which an oxiglutatione-containing solution or solid preparation is enclosed in one compartment and a bicarbonate ion solution is enclosed in another compartment and the space between the bag and the packaging member has a carbon dioxide gas atmosphere.
摘要翻译： 一种包装的眼睛冲洗溶液袋，其包括透气塑料多隔层袋和用于包装袋的气体不可渗透的塑料包装构件，其中将含氧化引发剂的溶液或固体制剂封闭在一个隔室中，并且碳酸氢根离子溶液 被封闭在另一个隔间中，并且袋和包装构件之间的空间具有二氧化碳气体气氛。
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3.发明申请DRUG SOLUTION HAVING REDUCED DISSOLVED OXYGEN CONTENT, METHOD OF PRODUCING THE SAME AND DRUG SOLUTION CONTAINING UNIT HAVING REDUCED DISSOLVED OXYGEN CONTENT 有权具有降低的溶解氧含量的药物溶液，其生产方法和包含具有降低的溶解氧含量的单元的药物溶液公开(公告)号：US20100092446A1
公开(公告)日：2010-04-15
申请号：US12447101
申请日：2007-10-25
IPC分类号： A61K31/4415 , A61K31/198 , A61K31/07 , A61K31/59 , A61K31/375 , A61K31/519 , A61K31/455 , A61P43/00
CPC分类号： A61J1/10 , A61J1/2093 , A61K9/08
摘要： It is an object of the present invention to provide a drug solution which has a reduced dissolved oxygen content and is less susceptible to oxidative degradation and highly stable over time, a production method therefor, and a drug solution containing pack which is capable of maintaining the dissolved oxygen content of a drug solution at a reduced level, less susceptible to oxidative degradation of the drug solution and highly stable over time. To achieve the aforementioned object, the reduced-dissolved-oxygen-content drug solution is produced by filling and sealing the drug solution in a drug solution container (15) formed of a plastic material having an oxygen permeability of not lower than 200 cm3/m2·24 h·atm at 25° C. at 60% RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm3/m2·24 h·atm at 25° C. at 60% RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.
摘要翻译： 本发明的目的是提供一种药物溶液，其溶解氧含量降低，并且不易氧化降解，随时间稳定性高，其制备方法和药物溶液包装，其能够维持 药物溶液的氧含量降低，对药物溶液的氧化降解敏感，并且随着时间的推移高度稳定。 为了实现上述目的，通过将药液填充并密封在由氧透过度不低于200cm 3 / m 2的塑料材料形成的药液容器（15）中来制造还原溶解氧含量药物溶液 ·蒸汽灭菌处理或热水灭菌处理后的12小时内，在25℃，60％RH的情况下，在25℃，24h·atm，稳态透氧度不高于100cm 3 / m 2·24h·atm 在60％RH下25℃，对药液容器进行蒸汽消毒处理或热水灭菌处理，并将药液容器储存在具有用于将药液溶解氧浓度降低的脱氧装置的环境中 当塑料材料的透氧性达到稳态水平时，高于2ppm。
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公开(公告)号：US20060154873A1
公开(公告)日：2006-07-13
申请号：US10559373
申请日：2004-06-04
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024
摘要： There is provided an aseptic combination preparation to be mixed at the time of use, characterized in that the same medicinal ingredients are divided and preserved in two or more chambers. The aseptic combination preparations according to the present invention are a mixing type at the time of their use and are useful as infusions, various dialysis fluids, intraocular perfusion/washing solutions, coronary perfusion solutions, myocardial protective solutions, peritoneal lavage solutions, solutions for organ preservations, etc., which can eliminate adverse effects caused by medical error on a living body.
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公开(公告)号：US09901513B2
公开(公告)日：2018-02-27
申请号：US12447101
申请日：2007-10-25
CPC分类号： A61J1/10 , A61J1/2093 , A61K9/08
摘要： A reduced-dissolved-oxygen-content drug solution produced by filling and sealing the drug solution in a drug solution container (15) formed of a plastic material having an oxygen permeability of not lower than 200 cm3/m2·24 h·atm at 25° C. at 60% RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm3/m2·24 h·atm at 25° C. at 60% RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.
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公开(公告)号：US08404274B2
公开(公告)日：2013-03-26
申请号：US10559373
申请日：2004-06-04
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024
摘要： There is provided an aseptic combination preparation to be mixed at the time of use, characterized in that the same medicinal ingredients are divided and preserved in two or more chambers. The aseptic combination preparations according to the present invention are a mixing type at the time of their use and are useful as infusions, various dialysis fluids, intraocular perfusion/washing solutions, coronary perfusion solutions, myocardial protective solutions, peritoneal lavage solutions, solutions for organ preservations, etc., which can eliminate adverse effects caused by medical error on a living body.
摘要翻译： 提供在使用时混合的无菌组合制剂，其特征在于将相同的药物成分分成并保存在两个或更多个室中。 根据本发明的无菌组合制剂是其使用时的混合型，可用作输注，各种透析液，眼内灌注/洗涤溶液，冠状动脉灌注溶液，心肌保护溶液，腹膜灌洗溶液，器官溶液 保护等，可以消除生物体的医疗误差引起的不良反应。
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7.发明申请公开(公告)号：US20060211631A1
公开(公告)日：2006-09-21
申请号：US10556772
申请日：2004-05-14
IPC分类号： A61K31/70 , A61K31/4172 , A61K31/405 , A61K31/401 , A61K31/198 , A61K31/51
CPC分类号： A61K31/51 , A61K31/401 , A61K31/405 , A61K31/4172 , A61K31/7004 , A61K33/14 , A61K2300/00
摘要： The infusion preparation for peripheral parenteral administration comprises an infusion (A) containing glucose with 80 to 200 g/L concentration, and an infusion (B) containing amino acid with 50 to 150 g/L concentration. The infusion (A) and the infusion (B) are separately put into a vessel that is divided with an openable partition means. The infusion (A) does not contain sulfite, has titratable acidity of 1 or less, contains vitamin B1 and is adjusted to pH 3 to 5. The infusion (B) is adjusted to pH 6.5 to 8. After mixing the both infusions, the mixture has pH 6 to 7.5 and titratable acidity of 5 to 10.
摘要翻译： 用于外周肠胃外给药的输注制剂包括含有80-200g / L浓度的葡萄糖的输注（A）和含有50-150g / L浓度的氨基酸的输注（B）。 输液（A）和输液（B）分别放入用可打开的分隔装置分开的容器中。 输液（A）不含亚硫酸盐，滴定酸度为1以下，含有维生素B1，调节至pH3〜5。输液（B）调节至pH6.5〜8。混合两次后， 混合物的pH为6〜7.5，滴定酸度为5〜10。
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