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    DRUG SOLUTION HAVING REDUCED DISSOLVED OXYGEN CONTENT, METHOD OF PRODUCING THE SAME AND DRUG SOLUTION CONTAINING UNIT HAVING REDUCED DISSOLVED OXYGEN CONTENT
    1.
    发明申请
    DRUG SOLUTION HAVING REDUCED DISSOLVED OXYGEN CONTENT, METHOD OF PRODUCING THE SAME AND DRUG SOLUTION CONTAINING UNIT HAVING REDUCED DISSOLVED OXYGEN CONTENT 有权
    具有降低的溶解氧含量的药物溶液，其生产方法和包含具有降低的溶解氧含量的单元的药物溶液

    公开(公告)号：US20100092446A1

    公开(公告)日：2010-04-15

    申请号：US12447101

    申请日：2007-10-25

    申请人： Nobuaki Sumiyoshi ,  Isamu Tateishi ,  Hitoshi Mori ,  Yasushi Morimoto

    发明人： Nobuaki Sumiyoshi ,  Isamu Tateishi ,  Hitoshi Mori ,  Yasushi Morimoto

    IPC分类号： A61K31/4415 ,  A61K31/198 ,  A61K31/07 ,  A61K31/59 ,  A61K31/375 ,  A61K31/519 ,  A61K31/455 ,  A61P43/00

    CPC分类号： A61J1/10 ,  A61J1/2093 ,  A61K9/08

    摘要： It is an object of the present invention to provide a drug solution which has a reduced dissolved oxygen content and is less susceptible to oxidative degradation and highly stable over time, a production method therefor, and a drug solution containing pack which is capable of maintaining the dissolved oxygen content of a drug solution at a reduced level, less susceptible to oxidative degradation of the drug solution and highly stable over time. To achieve the aforementioned object, the reduced-dissolved-oxygen-content drug solution is produced by filling and sealing the drug solution in a drug solution container (15) formed of a plastic material having an oxygen permeability of not lower than 200 cm3/m2·24 h·atm at 25° C. at 60% RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm3/m2·24 h·atm at 25° C. at 60% RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.

    摘要翻译： 本发明的目的是提供一种药物溶液，其溶解氧含量降低，并且不易氧化降解，随时间稳定性高，其制备方法和药物溶液包装，其能够维持 药物溶液的氧含量降低，对药物溶液的氧化降解敏感，并且随着时间的推移高度稳定。 为了实现上述目的，通过将药液填充并密封在由氧透过度不低于200cm 3 / m 2的塑料材料形成的药液容器（15）中来制造还原溶解氧含量药物溶液 ·蒸汽灭菌处理或热水灭菌处理后的12小时内，在25℃，60％RH的情况下，在25℃，24h·atm，稳态透氧度不高于100cm 3 / m 2·24h·atm 在60％RH下25℃，对药液容器进行蒸汽消毒处理或热水灭菌处理，并将药液容器储存在具有用于将药液溶解氧浓度降低的脱氧装置的环境中 当塑料材料的透氧性达到稳态水平时，高于2ppm。

    Drug solution container package and method for manufacturing the same
    3.
    发明授权
    Drug solution container package and method for manufacturing the same 有权
    药液容器包装及其制造方法

    公开(公告)号：US08465819B2

    公开(公告)日：2013-06-18

    申请号：US11911644

    申请日：2006-04-19

    申请人： Isamu Tateishi ,  Hitoshi Mori ,  Yasushi Morimoto

    发明人： Isamu Tateishi ,  Hitoshi Mori ,  Yasushi Morimoto

    IPC分类号： B32B1/02 ,  B32B27/08 ,  B32B27/30 ,  B32B27/32 ,  B32B27/36 ,  B65D85/84 ,  A61L2/08 ,  A61L2/18 ,  B65B29/00 ,  B65B55/04 ,  B65B31/00

    CPC分类号： B32B27/32 ,  A61J1/10 ,  A61M2207/00 ,  Y10T428/1352 ,  Y10T428/1379 ,  Y10T428/1383

    摘要： A drug solution container package, which can restrain degradation of a drug solution, proliferation of microbes, etc. accompanying the transmission of oxygen in a high degree while maintaining characteristics required of plastic drug solution containers such as heat resistance, impact resistance, pliability, transparency, and resistance against elution of plastic forming material, and to provide a method for manufacturing the drug solution container package. A drug solution is first contained and sealed in a plastic drug solution container having an oxygen gas transmission rate (25° C., 60% RH) of not less than 200 cm3/m2·24 h·atm within twelve hours after being subject to steam or hot water sterilization, and having an oxygen gas transmission rate (25° C., 60% RH) of not more than 100 cm3/m2·24 h·atm when the oxygen gas transmission rate is in a steady state, and thereafter the plastic drug solution container is steam sterilized or hot water sterilized and then contained and sealed along with an oxygen scavenger in an outer pouch having an oxygen barrier property.

    摘要翻译： 一种能够抑制药物溶液降解，微生物等的增殖，同时高度渗透氧气的同时保持塑料药液容器所需的特性，如耐热性，耐冲击性，柔韧性，透明性的药液容器包装 ，以及抗塑性成型材料的洗脱性，并提供制造药液容器包装的方法。 首先将药液包封并密封在氧气透过率（25℃，60％RH）以上的塑料药液容器中，在不小于200cm 3 / m 2·24h·atm之后的12小时内 蒸汽或热水灭菌，当氧气透过率处于稳定状态时，氧气透过率（25℃，60％RH）不大于100立方厘米/ 24小时·大气压，此后 塑料药液容器经蒸汽灭菌或热水灭菌，然后与除氧剂一起包含并密封在具有阻氧性的外袋中。

    Drug Solution Container Package and Method for Manufacturing the Same
    4.
    发明申请
    Drug Solution Container Package and Method for Manufacturing the Same 有权
    药物溶液容器包装及其制造方法

    公开(公告)号：US20090032426A1

    公开(公告)日：2009-02-05

    申请号：US11911644

    申请日：2006-04-19

    申请人： Isamu Tateishi ,  Hitoshi Mori ,  Yasushi Morimoto

    发明人： Isamu Tateishi ,  Hitoshi Mori ,  Yasushi Morimoto

    IPC分类号： A61J1/05 ,  B65B55/10

    CPC分类号： B32B27/32 ,  A61J1/10 ,  A61M2207/00 ,  Y10T428/1352 ,  Y10T428/1379 ,  Y10T428/1383

    摘要： An object of this invention is to provide a drug solution container package, which can restrain degradation of a drug solution, proliferation of microbes, etc. accompanying the transmission of oxygen in a high degree while maintaining characteristics required of plastic drug solution containers such as heat resistance, impact resistance, pliability, transparency, and resistance against elution of plastic forming material, and to provide a method for manufacturing the drug solution container package. In the present invention, to achieve the above object, a drug solution is contained and sealed in a plastic drug solution container having an oxygen gas transmission rate (25° C., 60% RH) of not less than 200 cm3/m2·24h·atm within twelve hours after being subject to steam sterilization or hot water sterilization, and having an oxygen gas transmission rate (25° C., 60% RH) of not more than 100 cm3/m2·24 h·atm when the oxygen gas transmission rate is in a steady state, and thereafter the plastic drug solution container is steam sterilized or hot water sterilized and then are contained and sealed along with an oxygen scavenger in an outer pouch having an oxygen barrier property.

    摘要翻译： 本发明的目的是提供一种药液溶液容器包装，其能够在保持塑料药液容器例如热量所需的特性的同时高效地抑制药物溶液的降解，微生物等的增殖，伴随氧传递。 电阻，耐冲击性，柔韧性，透明性和耐洗脱性，并提供制造药液容器包装的方法。 在本发明中，为了达到上述目的，将药液包含并密封在氧气透过率（25℃，60％RH）为200cm 3 / m 2以上的塑料药液容器中，24h 在进行蒸汽灭菌或热水灭菌后的十二个小时内，当氧气气体的氧气透过率（25℃，60％RH）为不大于100立方厘米/平方米时， 透射率处于稳定状态，然后将塑料药液容器进行蒸汽灭菌或热水灭菌，然后与含氧阻隔性的外袋中的除氧剂一起被包含并密封。

    Drug container and multilayer film
    7.
    发明授权
    Drug container and multilayer film 有权
    药物容器和多层膜

    公开(公告)号：US08328783B2

    公开(公告)日：2012-12-11

    申请号：US12669785

    申请日：2008-07-15

    申请人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto ,  Tatsuro Tsuruoka ,  Yasushi Nagata

    发明人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto ,  Tatsuro Tsuruoka ,  Yasushi Nagata

    IPC分类号： A61B19/00 ,  B32B27/08

    CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  B32B27/08 ,  B32B27/32 ,  Y10T428/31913

    摘要： A drug container of a multilayer film including a first layer (1) composed of a linear ethylene/α-olefin copolymer having a density of 0.930 to 0.950 g/cm3, a second layer (2) and a fourth layer (4) each composed of a mixture containing a linear ethylene/α-olefin copolymer having a density of 0.860 to 0.920 g/cm3 in a weight ratio of 95:5 to 40:60, a third layer (3) composed of a polycycloolefin, and a fifth layer (5) composed of a mixture containing a polyethylene and a polypropylene, the fifth layer 5 serving as an innermost layer.

    摘要翻译： 一种多层膜的药物容器，包括由密度为0.930〜0.950g / cm 3的线性乙烯/α-烯烃共聚物构成的第一层（1），第二层（2）和第四层（4） 包含重量比为95:5至40:60的密度为0.860至0.920g / cm3的线性乙烯/α-烯烃共聚物的混合物，由聚环烯烃组成的第三层（3）和第五层 （5）由含有聚乙烯和聚丙烯的混合物构成，第五层5作为最内层。

    DRUG CONTAINER AND MULTILAYER FILM
    8.
    发明申请
    DRUG CONTAINER AND MULTILAYER FILM 有权
    药物容器和多层膜

    公开(公告)号：US20100298804A1

    公开(公告)日：2010-11-25

    申请号：US12669785

    申请日：2008-07-15

    申请人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto ,  Tatsuro Tsuruoka ,  Yasushi Nagata

    发明人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto ,  Tatsuro Tsuruoka ,  Yasushi Nagata

    IPC分类号： A61B19/00 ,  B32B27/08

    CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  B32B27/08 ,  B32B27/32 ,  Y10T428/31913

    摘要： It is an object of the present invention to provide a drug container excellent in unsealability, gas barrier property, contamination resistance, heat resistance, antiblocking property and transparency, and to provide a multilayer film for production of the drug container. To achieve the object, the drug container is formed, for example, of a multilayer film including a first layer (1) composed of a linear ethylene/α-olefin copolymer having a density of 0.930 to 0.950 g/cm3, a second layer (2) and a fourth layer (4) each composed of a mixture containing a linear ethylene/α-olefin copolymer having a density of 0.860 to 0.920 g/cm3 and a linear ethylene/α-olefin copolymer having a density of 0.930 to 0.950 g/cm3 in a weight ratio of 95:5 to 40:60, a third layer (3) composed of a polycycloolefin, and a fifth layer (5) composed of a mixture containing a polyethylene and a polypropylene, the fifth layer 5 serving as an innermost layer.

    摘要翻译： 本发明的目的是提供一种非开封性，阻气性，耐污染性，耐热性，防粘连性和透明性优异的药物容器，提供制造药物容器的多层膜。 为了实现该目的，药物容器例如由包含由密度为0.930〜0.950g / cm 3的线性乙烯/α-烯烃共聚物构成的第一层（1）的多层膜形成，第二层（ 2）和第四层（4），每层由含有密度为0.860至0.920g / cm3的线性乙烯/α-烯烃共聚物和密度为0.930至0.950g的线性乙烯/α-烯烃共聚物的混合物 重量比为95:5至40:60的第三层（3）和由聚环烯烃组成的第三层（5）和由含有聚乙烯和聚丙烯的混合物组成的第五层（5），第五层5作为 最内层

    MULTILAYER FILM AND CONTAINER
    9.
    发明申请
    MULTILAYER FILM AND CONTAINER 有权
    多层膜和容器

    公开(公告)号：US20100143627A1

    公开(公告)日：2010-06-10

    申请号：US12528305

    申请日：2008-02-18

    申请人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto

    发明人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto

    IPC分类号： B32B1/02 ,  B32B27/08 ,  B32B7/02

    CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  A61M2207/00 ,  B32B27/08 ,  B32B27/32 ,  B32B2250/05 ,  B32B2270/00 ,  B32B2307/306 ,  B32B2307/412 ,  B32B2307/558 ,  B32B2307/748 ,  B32B2439/00 ,  B32B2439/80 ,  B65D65/40 ,  Y10T428/13 ,  Y10T428/1303 ,  Y10T428/1352 ,  Y10T428/1359 ,  Y10T428/139 ,  Y10T428/2495 ,  Y10T428/31913 ,  Y10T428/31924

    摘要： To provide a multilayer film and a container formed of the multilayer film which are excellent in unsealability, transparency, mechanical strength and sterilization heat resistance and are capable of preventing exudation of additives from the film into a liquid contained in the container.In a multilayer film including a first layer (1), a second layer (2), a third layer (3), a fourth layer (4) and a fifth layer (5) stacked in this order, the first layer (1) is composed of a propylene-ethylene random copolymer and/or a polypropylene homopolymer, and the second layer (2) and the fourth layer (4) are each composed of a mixture of a propylene-ethylene random copolymer and an α-olefin elastomer. The third layer (3) is composed of a mixture of a polycycloolefin and a polyethylene, and the fifth layer (5) is composed of a mixture containing a polypropylene homopolymer and a propylene-ethylene random copolymer in a weight ratio of 90:10 to 10:90. A container is formed of the multilayer film with an outer layer and an inner layer thereof being defined by the first layer (1) and the fifth layer (5), respectively.

    摘要翻译： 为了提供多层膜和由多层膜形成的容器，其开封性，透明性，机械强度和耐消毒性均优异，并且能够防止添加剂从膜中渗出到包含在容器中的液体中。 在包括依次堆叠的第一层（1），第二层（2），第三层（3），第四层（4）和第五层（5）的多层膜中，第一层（1） 由丙烯 - 乙烯无规共聚物和/或聚丙烯均聚物组成，第二层（2）和第四层（4）由丙烯 - 乙烯无规共聚物和α-烯烃弹性体的混合物组成。 第三层（3）由聚环烯烃和聚乙烯的混合物组成，第五层（5）由含有聚丙烯均聚物和丙烯 - 乙烯无规共聚物的混合物组成，重量比为90:10至 10:90。 容器由多层膜形成，其外层和内层分别由第一层（1）和第五层（5）限定。

    Multilayer film and container
    10.
    发明授权
    Multilayer film and container 有权
    多层膜和容器

    公开(公告)号：US08784958B2

    公开(公告)日：2014-07-22

    申请号：US12528305

    申请日：2008-02-18

    申请人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto

    发明人： Fujio Inoue ,  Isamu Tateishi ,  Yasushi Morimoto

    IPC分类号： B32B1/02 ,  B32B1/08

    CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  A61M2207/00 ,  B32B27/08 ,  B32B27/32 ,  B32B2250/05 ,  B32B2270/00 ,  B32B2307/306 ,  B32B2307/412 ,  B32B2307/558 ,  B32B2307/748 ,  B32B2439/00 ,  B32B2439/80 ,  B65D65/40 ,  Y10T428/13 ,  Y10T428/1303 ,  Y10T428/1352 ,  Y10T428/1359 ,  Y10T428/139 ,  Y10T428/2495 ,  Y10T428/31913 ,  Y10T428/31924

    摘要： In a multilayer film including a first layer (1), a second layer (2), a third layer (3), a fourth layer (4) and a fifth layer (5) stacked in this order, the first layer (1) is composed of a propylene-ethylene random copolymer and/or a polypropylene homopolymer, and the second layer (2) and the fourth layer (4) are each composed of a mixture of a propylene-ethylene random copolymer and an α-olefin elastomer. The third layer (3) is composed of a mixture of a polycycloolefin and polyethylene, and the fifth layer (5) is composed of a mixture containing a polypropylene homopolymer and a propylene-ethylene random copolymer in a weight ratio of 90:10 to 10:90. A container is formed of the multilayer film with an outer layer and an inner layer thereof being defined by the first layer (1) and the fifth layer (5), respectively.

    摘要翻译： 在包括依次堆叠的第一层（1），第二层（2），第三层（3），第四层（4）和第五层（5）的多层膜中，第一层（1） 由丙烯 - 乙烯无规共聚物和/或聚丙烯均聚物组成，第二层（2）和第四层（4）由丙烯 - 乙烯无规共聚物和α-烯烃弹性体的混合物组成。 第三层（3）由聚环烯烃和聚乙烯的混合物组成，第五层（5）由含有聚丙烯均聚物和丙烯 - 乙烯无规共聚物的混合物组成，重量比为90:10至10 ：90。 容器由多层膜形成，其外层和内层分别由第一层（1）和第五层（5）限定。