-
公开(公告)号：US20090246873A1
公开(公告)日：2009-10-01
申请号：US12415285
申请日：2009-03-31
IPC分类号： C12N5/06
摘要： To provide a scaffold for tissue engineering which consists of a bioabsorbable polymer material to be absorbed in a biotissue, and holds strength of the whole scaffold while having a porosity proper for culturing cells inside thereof as well, a method for producing the scaffold for tissue engineering includes steps of dissolving a bioabsorbable polymer material with an organic solvent, drying the solution so as to produce a porous bioabsorbable polymer material having a porosity of 50 to 99%, covering the porous bioabsorbable polymer material with a bioabsorbable polymer material having a thickness of 0.01 to 5 mm, pores of 10 to 3000 μm diameter, a fracture strength of 0.05 to 0.15 MPa, and a volume of 15 to 90% with respect to the whole scaffold.
摘要翻译： 提供一种用于组织工程的支架，其由吸收在生物组织中的生物可吸收聚合物材料组成，并且保持整个支架的强度同时具有适合于在其内部培养细胞的孔隙度，一种用于组织工程支架的生产方法 包括将生物可吸收聚合物材料与有机溶剂一起溶解的步骤，干燥该溶液以产生孔隙率为50至99％的多孔生物可吸收聚合物材料，用具有厚度为0.01的生物可吸收聚合物材料覆盖多孔生物可吸收聚合物材料 至5mm，孔径为10-3000μm直径，断裂强度为0.05-0.15MPa，体积相对于整个支架为15-90％。
-
公开(公告)号：US20090228027A1
公开(公告)日：2009-09-10
申请号：US12401121
申请日：2009-03-10
CPC分类号： C12N5/0655 , A61L27/18 , A61L27/3817 , A61L27/3821 , A61L27/3834 , A61L27/3847 , A61L27/3895 , A61L27/58 , A61L2430/02 , C12N2500/84 , C12N2506/1353 , C12N2533/40
摘要： To provide a bone tissue regeneration sheet having a cortical bone tissue layer of 200 μm or more in thickness, the bone tissue regeneration sheet is produced by seeding chondroblast or stem cells for differentiating to chondrocyte on one side of a porous bioabsorbable polymer sheet, taking the seeded porous body into a culture medium, applying centrifugal force of 100 to 1000 G to the culture medium for a predetermined time so as to aggregate the chondroblast or the stem cells for differentiating to chondrocyte, culturing the aggregated cells in a culture medium not containing serum but containing one or two or more kinds selected from ascorbic acid, an ascorbic acid derivative, and dexamethasone without applying centrifugal force to form a chondrocyte layer having a thickness of 200 μm or more.
摘要翻译： 为了提供具有厚度为200μm以上的皮层骨组织层的骨组织再生片，通过将成软骨细胞或干细胞接种到多孔生物可吸收性聚合物片的一面上来分化为软骨细胞来生产骨组织再生片， 将多孔体接种到培养基中，向培养液中施加100〜1000G的离心力达预定时间，以将软骨细胞或干细胞聚集成软骨细胞，在不含血清的培养基中培养聚集的细胞 但含有选自抗坏血酸，抗坏血酸衍生物和地塞米松中的一种或两种以上，而不施加离心力，形成厚度为200μm以上的软骨细胞层。
-
公开(公告)号：US20090299475A1
公开(公告)日：2009-12-03
申请号：US12475831
申请日：2009-06-01
IPC分类号： A61F2/28
CPC分类号： A61L27/12 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： To provide a bone graft substitute having an appropriate absorption period in a living body and high osteoconductivity, the bone graft substitute contains a carbonate apatite and an osteoinductive factor, the osteoinductive factor is preferably at least one kind selected from a group including BMP (a bone morphogenetic protein), GDF (a growth differentiation factor), TGF-β (a transformation growth factor), FGF (a fibroblast growth factor), IGF (an insulin-like growth factor), PDGF (a platelet-derived growth factor), BDNF (a brain-derived nerve growth factor), and NGF (a nerve growth factor), and the bone graft substitute has open pores, preferably having a diameter of 50 to 1000 μm and/or a diameter of 0.001 to 5 μm, with porosity of 20 to 80%.
摘要翻译： 为了提供在生物体中具有适当的吸收期和高的骨传导性的骨移植物替代物，骨移植物替代物含有碳酸磷灰石和骨诱导因子，骨诱导因子优选为选自包括BMP（骨骼） 形态发生蛋白），GDF（生长分化因子），TGF-β（转化生长因子），FGF（成纤维细胞生长因子），IGF（胰岛素样生长因子），PDGF（血小板衍生生长因子） BDNF（脑源性神经生长因子）和NGF（神经生长因子），骨移植物替代物具有开孔，优选直径为50〜1000μm，直径为0.001〜5μm， 孔隙率为20〜80％。
-
公开(公告)号：US20070233277A1
公开(公告)日：2007-10-04
申请号：US11694043
申请日：2007-03-30
CPC分类号： A61B17/1128 , A61B2017/00004 , A61L27/18 , A61L27/50 , A61L27/58 , C08L67/04
摘要： To provide an organism absorbency tube for regenerating nerve tissue and a production method thereof, where the low cost tube can produce easier than a conventional one, various kinds of the different thickness tubes, inner diameters and outer shapes can be easily formed. The tube produces by drying polymer solvent to form sheet-like organism absorbency polymer material; cylindrically rolling thus material to form an overlapped sheet part; heat or solvent meld sealing at least a portion around an end edge on the outer peripheral side thereof. Or a two layers structure tube produces by freeze-drying polymer solvent to form the material; cylindrically rolling thus material; non-freeze-drying polymer solvent to form the high material; cylindrically wrapping thus material around the freeze-dried polymer material to form the sheet part; and heat or solvent meld sealing at least a portion around an edge on the outer peripheral side thereof.
摘要翻译： 为了提供用于再生神经组织的生物体吸收管及其制造方法，其中低成本管可以比常规生产更容易制造，可以容易地形成各种不同厚度的管，内径和外形。 管通过干燥聚合物溶剂生成片状生物体吸收性聚合物材料; 圆柱滚动，从而形成重叠的片部分; 热或溶剂在其外周侧的端缘周围的至少一部分进行熔融密封。 或者通过冷冻干燥聚合物溶剂形成两层结构管来形成材料; 圆柱滚动如此材料; 非冷冻干燥聚合物溶剂形成高材料; 在冷冻干燥的聚合物材料周围圆周包裹这样的材料以形成片材部分; 并且在其外周侧上的边缘周围的至少一部分进行热或溶剂的熔融密封。
-
-
-
搜索结果
4 条记录 (耗时 0.019 秒)
