利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.025 秒)

    AGENTS FOR PROMOTING TISSUE REGENERATION BY RECRUITING BONE MARROW MESENCHYMAL STEM CELLS AND/OR PLURIPOTENT STEM CELLS INTO BLOOD
    1.
    发明申请
    AGENTS FOR PROMOTING TISSUE REGENERATION BY RECRUITING BONE MARROW MESENCHYMAL STEM CELLS AND/OR PLURIPOTENT STEM CELLS INTO BLOOD 审中-公开
    通过将骨髓间充质干细胞和/或多发性干细胞收集到血液中促进组织再生的药剂

    公开(公告)号：US20120251510A1

    公开(公告)日：2012-10-04

    申请号：US13503329

    申请日：2010-10-28

    申请人： Katsuto Tamai ,  Yasufumi Kaneda ,  Takehiko Yamazaki ,  Takenao Chino ,  Kotaro Saga ,  Mayumi Endo

    发明人： Katsuto Tamai ,  Yasufumi Kaneda ,  Takehiko Yamazaki ,  Takenao Chino ,  Kotaro Saga ,  Mayumi Endo

    IPC分类号： A61K38/17 ,  C12N5/10 ,  C12N15/85 ,  C12N5/0775 ,  A61K31/7088 ,  A61P25/00 ,  A61P19/00 ,  A61P17/00 ,  C07K14/47 ,  A61K35/12

    CPC分类号： A61K35/28 ,  A61K48/00 ,  C07K14/47

    摘要： It was revealed that the intravenous administration of HMGB-1 and S100A8 promoted the healing of skin ulcer by recruiting bone marrow-derived cells to the site of skin ulcer. Furthermore, when HMGB-1 was intravenously administered to cerebral infarction model mice after creation of cerebral infarction, bone marrow-derived cells expressing nerve cell markers were detected in their brain. A marked cerebral infarct-reducing effect was observed in mice intravenously administered with HMGB-1 as compared to the control. The post-cerebral infarction survival rate was increased in the intravenous HMGB-1 administration group. The involvement of bone marrow pluripotent stem cells in the process of bone fracture healing was assessed using mice, and the result demonstrated that bone marrow-derived cells distant from the damaged site migrated to the bone fracture site to repair the damaged tissue.

    摘要翻译： 据透露，HMGB-1和S100A8的静脉内给药通过将骨髓来源的细胞募集到皮肤溃疡部位来促进皮肤溃疡愈合。 此外，在脑梗死后，将HMGB-1静脉内施用于脑梗死模型小鼠时，在脑中检测到表达神经细胞标志物的骨髓来源的细胞。 与对照相比，静脉内施用HMGB-1的小鼠中观察到显着的脑梗死减轻作用。 静脉注射HMGB-1给药组脑梗死后存活率升高。 使用小鼠评估骨髓多能干细胞参与骨折愈合过程，结果表明远离受损部位的骨髓来源的细胞迁移到骨折部位以修复受损组织。

    PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF
    5.
    发明申请
    PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF 审中-公开
    诱导组织再生的用途及其用途

    公开(公告)号：US20140206619A1

    公开(公告)日：2014-07-24

    申请号：US14114395

    申请日：2012-04-03

    申请人： Katsuto Tamai ,  Takehiko Yamazaki ,  Tsutomu Kanezaki ,  Shigeru Sakurai ,  Yukiko Noguchi ,  Mayumi Endo ,  Natsumi Hamabuchi ,  Kana Naito

    发明人： Katsuto Tamai ,  Takehiko Yamazaki ,  Tsutomu Kanezaki ,  Shigeru Sakurai ,  Yukiko Noguchi ,  Mayumi Endo ,  Natsumi Hamabuchi ,  Kana Naito

    IPC分类号： C07K14/47

    CPC分类号： C07K14/4705 ,  A61K38/17 ,  C07K14/4702

    摘要： (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.

    摘要翻译： （目的）本发明的目的是提供治疗剂，其与PDGFRα阳性细胞如骨髓间充质干细胞的刺激相关联，促进其动员到血液中并积累在受损组织中，并诱导组织再生 一个活体。 （溶液手段）合成多肽，评价各肽的迁移促进活性。 结果，本发明人成功地鉴定了对PDGFRα阳性骨髓间充质干细胞系（MSC-1）具有迁移促进活性的多种肽。 此外，本发明人确认鉴定的肽也对皮肤成纤维细胞具有迁移促进活性，PDGFα阳性细胞为PDGFRα阳性细胞。