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    Truncated aggrecanase molecules
    1.
    发明申请
    Truncated aggrecanase molecules 审中-公开
    截短的聚蛋白聚糖酶分子

    公开(公告)号：US20070161046A1

    公开(公告)日：2007-07-12

    申请号：US11640482

    申请日：2006-12-15

    申请人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    发明人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64 ,  C07K16/40

    CPC分类号： C12N9/6421

    摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

    摘要翻译： 公开了截短的聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列及其生产方法。 此外，还公开了与野生型或天然聚集蛋白聚糖蛋白聚糖酶相比导致增加的稳定性和表达水平的氨基酸突变的聚集蛋白聚糖蛋白聚糖酶。 本发明的骨灰蛋白酶特别可用于开发用于治疗疾病如骨关节炎的组合物。 还公开了开发聚蛋白聚糖酶的抑制剂的方法和用于治疗以聚集蛋白聚糖降解为特征的病症的酶的抗体的方法。

    Truncated aggrecanase molecules
    2.
    发明申请
    Truncated aggrecanase molecules 失效
    截短的聚蛋白聚糖酶分子

    公开(公告)号：US20060257989A1

    公开(公告)日：2006-11-16

    申请号：US11488340

    申请日：2006-07-18

    申请人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    发明人： Katy Georgiadis ,  Tara Crawford ,  Kathleen Tomkinson ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Bethany Freeman ,  Edward LaVallie

    IPC分类号： C12N9/64 ,  C07H21/04 ,  C12P21/06 ,  C07K16/40

    CPC分类号： C12N9/6421

    摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.

    摘要翻译： 公开了截短的聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列及其生产方法。 此外，还公开了与野生型或天然聚集蛋白聚糖蛋白聚糖酶相比导致增加的稳定性和表达水平的氨基酸突变的聚集蛋白聚糖蛋白聚糖酶。 本发明的骨灰蛋白酶特别可用于开发用于治疗疾病如骨关节炎的组合物。 还公开了开发聚蛋白聚糖酶的抑制剂的方法和用于治疗以聚集蛋白聚糖降解为特征的病症的酶的抗体的方法。