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公开(公告)号：US20120196808A1
公开(公告)日：2012-08-02
申请号：US13409976
申请日：2012-03-01
申请人： Kazimierz Wisniewski , Claudio Schteingart , Regent LaPorte , Robert Felix Galyean , Pierre Riviere
发明人： Kazimierz Wisniewski , Claudio Schteingart , Regent LaPorte , Robert Felix Galyean , Pierre Riviere
摘要： The present application relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本申请涉及新化合物，包含其的药物组合物，所述化合物在制备用于治疗特别是休克条件的药物中的用途以及治疗所述病症的方法，其中施用所述化合物。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US08148319B2
公开(公告)日：2012-04-03
申请号：US11659215
申请日：2005-08-03
申请人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
发明人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
IPC分类号： A61K38/12
摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物，包含该化合物的药物组合物，所述化合物在制备用于治疗特别是休克条件的药物中的用途以及治疗所述病症的方法，其中所述化合物被给药。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US20090054309A1
公开(公告)日：2009-02-26
申请号：US11659215
申请日：2005-08-03
申请人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
发明人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物，包含该化合物的药物组合物，所述化合物在制备用于治疗特别是休克条件的药物中的用途以及治疗所述病症的方法，其中所述化合物被给药。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US08778881B2
公开(公告)日：2014-07-15
申请号：US13409976
申请日：2012-03-01
申请人： Kazimierz Wisniewski , Claudio Schteingart , Regent LaPorte , Robert Felix Galyean , Pierre J.M. Riviere
发明人： Kazimierz Wisniewski , Claudio Schteingart , Regent LaPorte , Robert Felix Galyean , Pierre J.M. Riviere
摘要： The present application relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本申请涉及新化合物，包含其的药物组合物，所述化合物在制备用于治疗特别是休克条件的药物中的用途以及治疗所述病症的方法，其中施用所述化合物。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US08883965B2
公开(公告)日：2014-11-11
申请号：US12223654
申请日：2007-02-05
摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物，包含该化合物的药物组合物，所述化合物在制备用于治疗特别是休克条件的药物中的用途以及治疗所述病症的方法，其中所述化合物被给药。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US20110044905A1
公开(公告)日：2011-02-24
申请号：US12933858
申请日：2009-03-30
CPC分类号： C07K7/16
摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia compromised lactation conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物，包含该化合物的药物组合物，所述化合物用于制备用于治疗特别是受损的哺乳期条件的药物的用途以及所述条件的治疗方法，其中施用所述化合物。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US08580918B2
公开(公告)日：2013-11-12
申请号：US13503010
申请日：2010-10-21
申请人： Sudarkodi Alagarsamy , Guangcheng Jiang , Pierre Riviere , Claudio Daniel Schteingart , Javier Sueiras-Diaz , Kazimierz Wisniewski
发明人： Sudarkodi Alagarsamy , Guangcheng Jiang , Pierre Riviere , Claudio Daniel Schteingart , Javier Sueiras-Diaz , Kazimierz Wisniewski
CPC分类号： C07K14/605 , A61K38/00
摘要： Novel GLP-2 analogs with improved pharmacokinetic properties are described as well as their use in the treatment of disease.
摘要翻译： 描述了具有改善的药代动力学性质的新型GLP-2类似物以及它们在治疗疾病中的用途。
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公开(公告)号：US08748564B2
公开(公告)日：2014-06-10
申请号：US13496269
申请日：2010-09-21
IPC分类号： A61K38/11 , A61P25/00 , A61P1/00 , A61P15/10 , A61P15/04 , A61P15/00 , A61P15/14 , A61P7/04 , A61P25/22 , A61P35/00 , C07K7/16 , A61P29/00
摘要： The present invention relates to oxytocin receptor agonist compounds, pharmaceutical compositions comprising the same, use of such compounds for the manufacture of a medicament for treatment of inter alia, abdominal pain, irritable bowel syndrome (IBS), autism, erectile dysfunction, female sexual dysfunction, labor induction and maintenance, lactation induction and maintenance, postpartum hemorrhage, Post Traumatic Stress Disorder (PTSD), pain, anxiety and other conditions, as well as to methods for the treatment of such conditions, wherein such compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification:
摘要翻译： 本发明涉及催产素受体激动剂化合物，包含它们的药物组合物，这些化合物用于制造用于治疗特别是腹痛，肠易激综合征（IBS），自闭症，勃起功能障碍，女性性功能障碍 ，劳动诱导和维持，哺乳诱导和维持，产后出血，创伤后应激障碍（PTSD），疼痛，焦虑等条件，以及治疗这些病症的方法，其中施用这些化合物。 化合物由通式（I）表示，如在说明书中进一步定义：
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公开(公告)号：US20060247157A1
公开(公告)日：2006-11-02
申请号：US11457743
申请日：2006-07-14
CPC分类号： C07C229/26 , A61K38/00 , C07K7/16
摘要： More efficient and/or economical methods for synthesizing heptapeptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for synthesizing intermediates useful in synthesizing these oxytocin analogs are also provided.
摘要翻译： 提供用于合成催产素的七肽醇类似物的更有效和/或经济的方法以及可用于合成这种催产素类似物的新型中间体。 还提供了合成用于合成这些催产素类似物的中间体的有效和经济的方法。
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公开(公告)号：US07816489B2
公开(公告)日：2010-10-19
申请号：US11929494
申请日：2007-10-30
CPC分类号： C07C229/26 , A61K38/00 , C07K7/16
摘要： More efficient and/or economical methods for synthesizing heptapeptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for synthesizing intermediates useful in synthesizing these oxytocin analogs are also provided.
摘要翻译： 提供用于合成催产素的七肽醇类似物的更有效和/或经济的方法以及可用于合成这种催产素类似物的新型中间体。 还提供了合成用于合成这些催产素类似物的中间体的有效和经济的方法。
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