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公开(公告)号：US08580918B2
公开(公告)日：2013-11-12
申请号：US13503010
申请日：2010-10-21
申请人： Sudarkodi Alagarsamy , Guangcheng Jiang , Pierre Riviere , Claudio Daniel Schteingart , Javier Sueiras-Diaz , Kazimierz Wisniewski
发明人： Sudarkodi Alagarsamy , Guangcheng Jiang , Pierre Riviere , Claudio Daniel Schteingart , Javier Sueiras-Diaz , Kazimierz Wisniewski
CPC分类号： C07K14/605 , A61K38/00
摘要： Novel GLP-2 analogs with improved pharmacokinetic properties are described as well as their use in the treatment of disease.
摘要翻译： 描述了具有改善的药代动力学性质的新型GLP-2类似物以及它们在治疗疾病中的用途。
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公开(公告)号：US20110272112A1
公开(公告)日：2011-11-10
申请号：US13063695
申请日：2009-09-02
申请人： Bo-Christer Aberg , Cary P. Johnson , Francis L. Davenport , Pierre Riviere , John J. Lafond , Jonas Karlsson , Jean-Louis Monnerie
发明人： Bo-Christer Aberg , Cary P. Johnson , Francis L. Davenport , Pierre Riviere , John J. Lafond , Jonas Karlsson , Jean-Louis Monnerie
CPC分类号： D21F11/006 , B32B3/266 , D04H1/44 , D04H1/46 , D21F1/0027 , D21F1/0036 , Y10T428/24273 , Y10T428/24496 , Y10T428/24504
摘要： A fabric structure used to make textured nonwoven products, the structure being permeable to air and water, comprising a web contact surface having a pattern including a series of raised land areas and corresponding depressions adapted to impart a texture to the nonwoven product produced thereon, and a series of through voids adapted to allow passage of both water and/or air from the fabric surface into and/or through the structure.
摘要翻译： 一种用于制造纹理非织造产品的织物结构，该结构可渗透空气和水，包括具有包括一系列凸起区域的图案的纤维网接触表面和适于赋予其上产生的无纺织物的质地的相应凹陷，以及 适于允许水和/或空气从织物表面进入和/或通过结构的一系列通孔。
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公开(公告)号：US20050059081A1
公开(公告)日：2005-03-17
申请号：US10982512
申请日：2004-11-05
申请人： Steve Qi , Karen Akinsanya , Pierre Riviere , Jean-Louis Junien
发明人： Steve Qi , Karen Akinsanya , Pierre Riviere , Jean-Louis Junien
IPC分类号： G01N33/50 , A61K45/00 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P17/06 , A61P21/04 , A61P25/08 , A61P25/14 , A61P31/12 , A61P35/02 , A61P43/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/09 , C12Q1/37 , G01N33/15 , G01N33/53 , G01N33/566 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/48 , C12N2799/026
摘要： Novel proteins or polypeptides having significant sequence homology to DPPIV, nucleic acids coding therefor, cells which have been modified with such nucleic acid so as to express these proteins, antibodies to these proteins, screening methods for the discovery of new therapeutic agents which are inhibitors of the activity of these proteins or of related proteins, and therapeutic agents discovered by such screening methods, as well as new therapeutic treatments, are all provided.
摘要翻译： 与DPPIV具有显着序列同源性的新型蛋白质或多肽，其编码的核酸，已经用此类核酸修饰以表达这些蛋白质的细胞，对这些蛋白质的抗体，用于发现作为这些蛋白质的抑制剂的新治疗剂的筛选方法 这些蛋白质或相关蛋白质的活性以及通过这种筛选方法发现的治疗剂以及新的治疗方法都被提供。
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公开(公告)号：US20120231999A1
公开(公告)日：2012-09-13
申请号：US13503010
申请日：2010-10-21
申请人： Sudarkodi Alagarsamy , Guangcheng Jiang , Pierre Riviere , Claudio Daniel Schteingart , Javier Sueiras-Diaz
发明人： Sudarkodi Alagarsamy , Guangcheng Jiang , Pierre Riviere , Claudio Daniel Schteingart , Javier Sueiras-Diaz
IPC分类号： A61K38/16 , A61P1/00 , A61P3/04 , A61P3/10 , A61P1/04 , A61P37/08 , A61P29/00 , A61P25/24 , A61P19/10 , A61P25/00 , C07K14/00 , A61P3/00
CPC分类号： C07K14/605 , A61K38/00
摘要： Novel GLP-2 analogs with improved pharmacokinetic properties are described as well as their use in the treatment of disease.
摘要翻译： 描述了具有改善的药代动力学性质的新型GLP-2类似物以及它们在治疗疾病中的用途。
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公开(公告)号：US6143722A
公开(公告)日：2000-11-07
申请号：US308912
申请日：1999-08-02
申请人： Per Melin , Anders Nilsson , Jerzy Trojnar , Carl-Johan Aurell , Pierre Riviere , Robert Haigh
发明人： Per Melin , Anders Nilsson , Jerzy Trojnar , Carl-Johan Aurell , Pierre Riviere , Robert Haigh
IPC分类号： A61K38/00 , A61K38/11 , A61P5/10 , A61P15/00 , A61P15/04 , A61P15/06 , A61P15/10 , A61P15/14 , A61P25/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , C07K7/02 , C07K7/16 , C07K5/00 , C07K7/00
摘要： Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal .beta.-aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the .beta.-aminoalcohol Z is --NR--CH(Q)--CH.sub.2 OH, Q is (CH.sub.2).sub.n --NH--A is H or --C(.dbd.NH)NH.sub.2, and R is CH.sub.3 or C.sub.2 H.sub.5, and the moiety S wherein H is a D-aromatic .alpha.-aminoacid and Y is an aliphatic .alpha.-aminoacid and have oxytocin antagonist activity. Also disclosed is: a method of their synthesis; pharmaceutical compositions containing these analogues; the synthesis of such compositions; a method of control of uterine contractions.
摘要翻译： PCT No.PCT / SE97 / 01968 Sec。 371日期：1999年8月2日 102（e）1999年8月2日PCT 1997年11月21日PCT PCT。 WO98 / 23636 PCT公开号 日期1998年6月4日其肽类似物或其药学上可接受的盐由六肽部分S和通过酰胺键与部分S结合的C-末端β-氨基醇残基Z组成，其中β-氨基醇Z是-NR-CH（ Q）-CH 2 OH，Q是（CH 2）n -NH-A是H或-C（= NH）NH 2，R是CH 3或C 2 H 5，并且部分S其中H是D-芳族α-氨基酸，Y是 脂肪族α-氨基酸，并具有催产素拮抗剂活性。 还公开了它们的合成方法; 含有这些类似物的药物组合物; 这种组合物的合成; 一种控制子宫收缩的方法。
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公开(公告)号：US08758569B2
公开(公告)日：2014-06-24
申请号：US13063695
申请日：2009-09-02
申请人： Bo-Christer Aberg , Cary P. Johnson , Francis L. Davenport , Pierre Riviere , John J. Lafond , Jonas Karlsson , Jean-Louis Monnerie
发明人： Bo-Christer Aberg , Cary P. Johnson , Francis L. Davenport , Pierre Riviere , John J. Lafond , Jonas Karlsson , Jean-Louis Monnerie
CPC分类号： D21F11/006 , B32B3/266 , D04H1/44 , D04H1/46 , D21F1/0027 , D21F1/0036 , Y10T428/24273 , Y10T428/24496 , Y10T428/24504
摘要： A fabric structure used to make textured nonwoven products, the structure being permeable to air and water, comprising a web contact surface having a pattern including a series of raised land areas and corresponding depressions adapted to impart a texture to the nonwoven product produced thereon, and a series of through voids adapted to allow passage of both water and/or air from the fabric surface into and/or through the structure.
摘要翻译： 一种用于制造纹理非织造产品的织物结构，该结构可渗透空气和水，包括具有包括一系列凸起区域的图案的纤维网接触表面和适于赋予其上产生的无纺织物的质地的相应凹陷，以及 适于允许水和/或空气从织物表面进入和/或通过结构的一系列通孔。
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公开(公告)号：US20090054309A1
公开(公告)日：2009-02-26
申请号：US11659215
申请日：2005-08-03
申请人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
发明人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物，包含该化合物的药物组合物，所述化合物在制备用于治疗特别是休克条件的药物中的用途以及治疗所述病症的方法，其中所述化合物被给药。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US20070018364A1
公开(公告)日：2007-01-25
申请号：US11185386
申请日：2005-07-20
申请人： Pierre Riviere
发明人： Pierre Riviere
IPC分类号： B29C67/20
摘要： A method and apparatus for forming a nonwoven product, including steps of forming a nonwoven web from a material and calendering the nonwoven web received following the forming step on a calender means. The method also including a step of obtaining information pertaining to a number of parameters of the calender means or to the formed nonwoven web from a sensor and controlling the calender means with the obtained information.
摘要翻译： 一种用于形成非织造产品的方法和设备，包括以下步骤：从材料形成非织造纤维网，并在压延机装置上压延在成型步骤之后接收的非织造纤维网。 该方法还包括从传感器获得关于砑光机构的多个参数的信息或形成的非织造纤维网的步骤，并利用获得的信息控制压延机构。
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9.发明授权−E-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethylpiperidine, and its antidiarrhoeal use 有权-E-2-（3,4-二氯肉桂基）-1-环丙基甲基哌啶及其抗腹泻用途公开(公告)号：US06440997B2
公开(公告)日：2002-08-27
申请号：US09367579
申请日：1999-11-10
申请人： Alain Calvet , Maria Chovet , Svein Dahl , Henry Jacobelli , Vassilia Theodorou , Pierre Riviere
发明人： Alain Calvet , Maria Chovet , Svein Dahl , Henry Jacobelli , Vassilia Theodorou , Pierre Riviere
IPC分类号： A61K31445
CPC分类号： C07D211/18
摘要： (−)E-2-(3,4-dichlorocinnamyl)-1-cyclo-propylmethyl-piperidine of formula I: and its pharmaceutically acceptable salts, is useful for treating diarrhea in mammals. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula I.
摘要翻译： （ - ）式I的E-2-（3,4-二氯肉桂基）-1-环丙基甲基哌啶及其药学上可接受的盐可用于治疗哺乳动物的腹泻。 还公开了药物组合物，制备式（I）化合物的方法和可用于制备式I化合物的中间体。
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公开(公告)号：US08148319B2
公开(公告)日：2012-04-03
申请号：US11659215
申请日：2005-08-03
申请人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
发明人： Kazimierz Wisniewski , Claudio Schteingart , Regent Laporte , Robert Felix Galyean , Pierre Riviere
IPC分类号： A61K38/12
摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物，包含该化合物的药物组合物，所述化合物在制备用于治疗特别是休克条件的药物中的用途以及治疗所述病症的方法，其中所述化合物被给药。 化合物由通式（I）表示，如说明书中进一步定义的。
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