公开(公告)号：US07049364B2

公开(公告)日：2006-05-23

申请号：US10616907

申请日：2003-07-11

申请人： Kazuhiko Maekawa ,  Mototsugu Yoshihara ,  Yukio Itoshima ,  Mamoru Omoda ,  Yukiatsu Komiya

发明人： Kazuhiko Maekawa ,  Mototsugu Yoshihara ,  Yukio Itoshima ,  Mamoru Omoda ,  Yukiatsu Komiya

IPC分类号： C08L53/00

CPC分类号： C09J151/006 ,  C08L51/006 ,  C08L53/00 ,  C08L2666/02 ,  C08L2666/04 ,  C08L2666/14 ,  C09D151/006 ,  C09D153/00 ,  C09J153/00

摘要： The invention provides an aqueous dispersion which includes i) an aqueous dispersion (I) resulting from dispersion of a block copolymer (I) composed of at least one polymer block (A) containing olefin monomer units and at least one polymer block (B) containing 2 to 100 mole percent of units derived from at least one vinyl monomer having a carboxyl or carboxylic anhydride group and 98 to 0 (zero) mole percent of units derived from another vinyl monomer or monomers copolymerizable with the carboxyl group- or carboxylic anhydride group-containing vinyl monomer, in an aqueous solution of not less than 0.05 equivalent, relative to the carboxyl or carboxylic anhydride group, of a basic substance, and ii) a polyurethane (II), iii) vinyl polymer (III) or iv) tackifier (IV) incorporated in the aqueous dispersion (I). The aqueous dispersion of the invention has excellent adhesiveness to various substrates and stability, and gives a coating layer having excellent weather resistance, water resistance and resistance to solvent attack. The aqueous dispersion of the invention is particularly useful as a coating composition and/or a primer.

公开(公告)号：US06610774B2

公开(公告)日：2003-08-26

申请号：US09893891

申请日：2001-06-29

申请人： Kazuhiko Maekawa ,  Mototsugu Yoshihara ,  Mitsuru Kato ,  Yukio Itoshima ,  Mamoru Omoda ,  Yukiatsu Komiya

发明人： Kazuhiko Maekawa ,  Mototsugu Yoshihara ,  Mitsuru Kato ,  Yukio Itoshima ,  Mamoru Omoda ,  Yukiatsu Komiya

IPC分类号： C08F29300

CPC分类号： C09J151/006 ,  C08L51/006 ,  C08L53/00 ,  C08L2666/02 ,  C08L2666/04 ,  C08L2666/14 ,  C09D151/006 ,  C09D153/00 ,  C09J153/00

摘要： The invention provides an aqueous dispersion which includes i) an aqueous dispersion (I) resulting from dispersion of a block copolymer (I) composed of at least one polymer block (A) containing olefin monomer units and at least one polymer block (B) containing 2 to 100 mole percent of units derived from at least one vinyl monomer having a carboxyl or carboxylic anhydride group and 98 to 0 (zero) mole percent of units derived from another vinyl monomer or monomers copolymerizable with the carboxyl group- or carboxylic anhydride group-containing vinyl monomer, in an aqueous solution of not less than 0.05 equivalent, relative to the carboxyl or carboxylic anhydride group, of a basic substance, and ii) a polyurethane (II), iii) vinyl polymer (III) or iv) tackifier (IV) incorporated in the aqueous dispersion (I). The aqueous dispersion of the invention has excellent adhesiveness to various substrates and stability, and gives a coating layer having excellent weather resistance, water resistance and resistance to solvent attack. The aqueous dispersion of the invention is particularly useful as a coating composition and/or a primer.

公开(公告)号：US06451901B1

公开(公告)日：2002-09-17

申请号：US09787424

申请日：2001-03-23

申请人： Kazuhiko Maekawa ,  Naohiko Uchiumi ,  Mamoru Omoda ,  Atsushi Itou

发明人： Kazuhiko Maekawa ,  Naohiko Uchiumi ,  Mamoru Omoda ,  Atsushi Itou

IPC分类号： C08L5300

CPC分类号： C08F8/44 ,  C08F293/005 ,  C08L53/00 ,  C08L2666/02 ,  C09J153/00 ,  C08F293/00

摘要： The invention is to provide an aqueous dispersion having good adhesiveness, especially airtight adhesiveness to various substrates, and having good storage stability, good weather resistance and good hydrophobicity. The aqueous dispersion comprises a block copolymer composed of polymer blocks (A) consisting essentially of olefin monomer units and polymer blocks (B) comprising from 2 to 100 mol % of units of vinyl monomers having a carboxyl group or a carboxylic acid anhydride group and from 0 to 98 mol % of units of other vinyl comonomers capable of copolymerizing with the vinyl monomers, dispersed in an aqueous solution of at least 0.05 equivalents, relative to the carboxyl group or the carboxylic acid anhydride group, of a basic substance.

摘要翻译： 本发明提供一种具有良好粘附性，特别是对各种基材的气密性的水分散体，具有良好的储存稳定性，良好的耐候性和良好的疏水性。 水分散体包括由基本上由烯烃单体单元组成的聚合物嵌段（A）和包含2至100摩尔％的具有羧基或羧酸酐基团的乙烯基单体的单元的聚合物嵌段（B）组成的嵌段共聚物， 0〜98摩尔％能够与乙烯基单体共聚的其它乙烯基共聚单体相对于羧基或羧酸酐基分散在相对于羧基或羧酸酐基团的水溶液中的单体。

公开(公告)号：US6096435A

公开(公告)日：2000-08-01

申请号：US35873

申请日：1998-03-06

申请人： Kazuhiko Maekawa ,  Masanari Uno ,  Atsushi Itoh ,  Hiroshi Hayashihara ,  Kazushige Ishiura ,  Shigeru Kawahara ,  Shiroh Kishii

发明人： Kazuhiko Maekawa ,  Masanari Uno ,  Atsushi Itoh ,  Hiroshi Hayashihara ,  Kazushige Ishiura ,  Shigeru Kawahara ,  Shiroh Kishii

IPC分类号： B32B27/30 ,  C08L23/02 ,  C08L53/02 ,  C09J153/02 ,  B23B27/08 ,  C08L31/02 ,  C08L53/00 ,  B23B27/30

CPC分类号： C08L23/02 ,  C08L53/02 ,  C08L53/025

摘要： A thermoplastic polymer composition is provided that includes 100 parts by weight of a block copolymer and/or its hydrogenate having polymer blocks of an aromatic vinyl compound and polymer blocks of a conjugated diene compound, and from 5 to 95 parts by weight of a block copolymer having polymer blocks of an aromatic vinyl compound and/or an olefinic compound and polymer blocks having a constitutional unit derived from a (meth) acrylic compound, a laminate containing a layer of the composition, and a hot-melt adhesive that includes the composition. Because it has good melt adhesiveness, the composition of the invention can firmly adhere in melt to various polar or non-polar materials. Using the composition, it is easy to produce laminates having a layer of the composition and a layer of some other material, through melt shaping or any other melt adhesion techniques. Since the composition of the invention is satisfactorily elastic and flexible, the laminates having a layer of the composition on their surface are flexible and elastic and have a good feel, and, in addition, they are safe because of their shock absorbability and cushionability.

摘要翻译： 提供一种热塑性聚合物组合物，其包含100重量份的嵌段共聚物和/或其具有芳族乙烯基化合物的聚合物嵌段和共轭二烯化合物的聚合物嵌段的氢化物和5至95重量份的嵌段共聚物 具有芳族乙烯基化合物和/或烯烃化合物的聚合物嵌段和具有衍生自（甲基）丙烯酸类化合物的结构单元的聚合物嵌段，含有该组合物的层的层压体和包含该组合物的热熔性粘合剂。 因为具有良好的熔融粘合性，所以本发明的组合物可以熔融地牢固地粘附到各种极性或非极性材料中。 使用该组合物，通过熔融成型或任何其它熔融粘附技术，易于制备具有组合物层和一些其它材料层的层压体。 由于本发明的组合物具有令人满意的弹性和柔性，所以在其表面上具有组合物层的层压体是柔性和弹性的并且具有良好的手感，并且由于它们的冲击吸收性和缓冲性，它们是安全的。

公开(公告)号：US20120035242A1

公开(公告)日：2012-02-09

申请号：US13143730

申请日：2010-01-08

申请人： Mana Iwata ,  Kazuhiko Maekawa ,  Tetsuya Yoshida

发明人： Mana Iwata ,  Kazuhiko Maekawa ,  Tetsuya Yoshida

IPC分类号： A61K31/713 ,  A61P3/10 ,  A61P3/04 ,  C07H21/02 ,  C40B30/04

CPC分类号： A61K31/713 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y602/01001 ,  C12N2310/531

摘要： The invention is intended to provide a pharmaceutical composition for treating or preventing obesity or type II diabetes and a method for treatment for them. A pharmaceutical composition comprising an Acsl-1 inhibitor of this invention as an active ingredient is useful for prevention or treatment of obesity or type II diabetes.

摘要翻译： 本发明旨在提供一种用于治疗或预防肥胖症或II型糖尿病的药物组合物及其治疗方法。 包含本发明的Acsl-1抑制剂作为活性成分的药物组合物可用于预防或治疗肥胖症或II型糖尿病。

公开(公告)号：US07371818B2

公开(公告)日：2008-05-13

申请号：US10451417

申请日：2001-12-26

申请人： Satoshi Orita ,  Rie Hayashi ,  Hikaru Sonoda ,  Kazuhiko Maekawa

发明人： Satoshi Orita ,  Rie Hayashi ,  Hikaru Sonoda ,  Kazuhiko Maekawa

IPC分类号： C07K1/00

CPC分类号： G01N33/57484 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/475 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574

摘要： A novel chordin-like polypeptide is found out in a protein secreted from mesenchymal stem cells. This polypeptide is useful as a cancer marker and a remedy for parotid cancer, lung cancer, esophagus cancer, gastric cancer, duodenal carcinoma, kidney cancer, ureteral cancer, testicular cancer, ovarian cancer, uterine cancer, leukemia, intestinal cancer, colon cancer, rectal cancer, biliary cancer or thyroid cancer cells, etc. Moreover, it is found out that the above polypeptide has an activity of modulating bone differentiation. Thus, this polypeptide is also useful as a bone disease marker and a remedy for bone diseases such as arthritis deformans, rheumatoid arthritis and osteoporosis.

摘要翻译： 在从间充质干细胞分泌的蛋白质中发现了一种新颖的类似脊索样的多肽。 该多肽可用作癌症标志物和腮腺癌，肺癌，食管癌，胃癌，十二指肠癌，肾癌，输尿管癌，睾丸癌，卵巢癌，子宫癌，白血病，肠癌，结肠癌， 直肠癌，胆道癌或甲状腺癌细胞等。此外，发现上述多肽具有调节骨分化的活性。 因此，该多肽也可用作骨疾病标记物和骨疾病如关节炎变形体，类风湿性关节炎和骨质疏松症的治疗方法。

公开(公告)号：US06537660B2

公开(公告)日：2003-03-25

申请号：US09805247

申请日：2001-03-14

申请人： Takashi Katayama ,  Kazuhiko Maekawa ,  Hitoshi Nakatsuka ,  Ichirou Inoue ,  Shuhei Yorimitsu

发明人： Takashi Katayama ,  Kazuhiko Maekawa ,  Hitoshi Nakatsuka ,  Ichirou Inoue ,  Shuhei Yorimitsu

IPC分类号： D01F600

CPC分类号： D01F8/14 ,  D01F6/46 ,  D01F8/06 ,  D01F8/12 ,  Y10T428/2913 ,  Y10T428/2924 ,  Y10T428/2929 ,  Y10T428/2969 ,  Y10T442/30 ,  Y10T442/60

摘要： The present invention relates to a fiber, which includes: 2 to 95% by weight, based on the total weight of the fiber, of at least one block copolymer, which includes: at least one polymer block (A) that includes 50 to 100% by weight of olefinic monomer units, based on the total weight of the block copolymer; and at least one polymer block (B) that includes 0.1 to 100% by weight of (meth)acrylic monomer units, based on the total weight of the block copolymer. Other embodiments of the invention include fibrous structures, non-woven fabrics, leather-like sheet materials, and dyed articles, which include the above-described fiber, and processes of making the above-described fiber. The present invention also relates to a composite fiber, and fibrous structures, non-woven fabrics, leather-like sheet materials, and dyed articles, which includes the above-described composite fiber, as well as processes for producing the above-described composite fiber.

摘要翻译： 本发明涉及纤维，其包括：基于纤维总重量的2-95重量％的至少一种嵌段共聚物，其包括：至少一种聚合物嵌段（A），其包含50至100 基于嵌段共聚物的总重量的烯烃单体单元的重量％; 以及基于嵌段共聚物的总重量，包含0.1至100重量％的（甲基）丙烯酸单体单元的至少一个聚合物嵌段（B）。 本发明的其它实施方案包括纤维结构，无纺布，皮革样片材和染色制品，其包括上述纤维，以及制备上述纤维的方法。 本发明还涉及包含上述复合纤维的复合纤维和纤维结构体，无纺布，皮革状片材和染色制品以及上述复合纤维的制造方法 。

公开(公告)号：US6155025A

公开(公告)日：2000-12-05

申请号：US81140

申请日：1998-05-19

申请人： Masao Komiya ,  Kazuhiko Maekawa ,  Shinji Nishizawa

发明人： Masao Komiya ,  Kazuhiko Maekawa ,  Shinji Nishizawa

IPC分类号： B65B5/08 ,  B65B5/10 ,  B65B21/06

CPC分类号： B65B5/10

摘要： An article packaging system has a magazine case charging mechanism for picking up and charging magazine cases one by one to a subsequent stage, a magazine case aligning mechanism for aligning the charged magazine cases in one direction, a small outer shipping package producing mechanism for storing a magazine case into a small package thereby to produce a small outer shipping package, a pack production mechanism for combining packs in a predetermined combining pattern, a large outer shipping package producing mechanism for assembling a plurality of packs in a predetermined assembling pattern into an assembly, and storing the assembly into a corrugated box to produce a large outer shipping package, and a production information management computer for controlling the above mechanisms in a centralized fashion. A complex packaging process of storing magazine cases into small boxes to produce small outer shipping packages, combining small outer shipping packages in any of various combining patterns into a pack, and storing a plurality of packs into a corrugated box to produce a large outer shipping package can easily be automatized.

摘要翻译： 物品包装系统具有一个一个到后一个阶段的用于拾取和充电杂志盒的杂志盒充电机构，一个用于使一个方向对准带电盒带盒的盒子对齐机构，用于存储一个 从而产生小的外部运输包装，用于以预定组合模式组合包装的包装生产机构，用于将预定组装图案中的多个包装组装成组件的大型外部运输包装生产机构， 并将组件存储在瓦楞纸箱中以产生大的外部运输包装，以及用于以集中的方式控制上述机构的生产信息管理计算机。 一种复杂的包装过程，将杂志箱存储在小盒子中以产生小的外部运输包装，将各种组合图案中的任何一种的小型外部运输包装组合成包装，并将多个包装存储在瓦楞纸箱中，以产生大的外部装运包装 可以轻松自动化。

公开(公告)号：US5847061A

公开(公告)日：1998-12-08

申请号：US537946

申请日：1995-11-21

申请人： Kazuhiko Maekawa ,  Toshiaki Sato

发明人： Kazuhiko Maekawa ,  Toshiaki Sato

IPC分类号： C08F2/38 ,  C08F4/00 ,  C08F4/40 ,  C08F2/00

CPC分类号： C08F2/38

摘要： A process for producing polymers having terminal functional group which may be protected, comprises polymerizing a radical-polymerizable monomer with a polymerization initiator comprising at least one member selected from the group (A) consisting of thio-S-carboxylic acids represented by the following general formula (1) and dithiocarboxylic acids represented by the following general formula (2) and at least one member selected from the group (B) consisting of polysulfides represented by the following general formula (3), polysulfides represented by the following general formula (4) and sulfoxides:. ##STR1## wherein R.sup.1 represents a hydrocarbon group which may have a substituent including functional group; ##STR2## wherein R.sup.2 represents a hydrocarbon group which may have a substituent including functional group; ##STR3## wherein R.sup.3 and R.sup.4 each represents a hydrocarbon group which may have a substituent including functional group and n is an integer of 2 or more; and R.sup.5 --(S)m-R.sup.6 ( 4) wherein R.sup.5 and R.sup.6 each represents a hydrocarbon group having a functional group and m is an integer of 2 or more. This process can produce polymers with which functional groups have been introduced into one end or both ends thereof; irrespective of the rate of polymerization or the degree of polymerization of the polymer that forms.

摘要翻译： PCT No.PCT / JP95 / 00499 Sec。 371日期：1995年11月21日 102（e）1995年11月21日日期PCT 1995年3月20日PCT公布。 WO95 / 25753 PCT出版物 日期1995年9月28日制备具有可被保护的末端官能团的聚合物的方法，包括使自由基聚合性单体与含有选自硫代S-羧酸（A） 由下述通式（1）表示的二硫代羧酸和由以下通式（2）表示的二硫代羧酸和选自由以下通式（3）表示的多硫化物组成的组（B）中的至少一种，由 以下通式（4）和亚砜：。 （1）其中R1表示可具有包含官能团的取代基的烃基; （2）其中R2表示可具有包含官能团的取代基的烃基; （3）其中R 3和R 4各自表示可以具有包含官能团的取代基并且n是2以上的整数的烃基; 和R 5 - （S）m -R 6（4）其中R 5和R 6各自表示具有官能团的烃基，m为2以上的整数。 该方法可以生产已经将官能团引入其一端或两端的聚合物; 不管形成的聚合物的聚合速度或聚合度如何。