公开(公告)号：US4605786A

公开(公告)日：1986-08-12

申请号：US563436

申请日：1983-12-20

申请人： Kazumasa Yokoyama ,  Yoshihisa Inoue ,  Taizo Ono ,  Chikara Fukaya ,  Yoshio Arakawa ,  Youichiro Naito ,  Koichi Yamauchi ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Yoshihisa Inoue ,  Taizo Ono ,  Chikara Fukaya ,  Yoshio Arakawa ,  Youichiro Naito ,  Koichi Yamauchi ,  Tadakazu Suyama

IPC分类号： C07C41/00 ,  C07C43/12 ,  C07C43/192 ,  C07C43/313 ,  C07C67/00 ,  C25B3/02 ,  C25B3/08

CPC分类号： C07C43/123 ,  C07C43/192 ,  C07C43/313 ,  Y10S514/832

摘要： A perfluoroether compound having the following formula is useful as a thermostable, inert solvent and inter alia as an oxygen carrier in an artificial blood or infusion fluid. ##STR1## wherein Rf.sub.1 and Rf.sub.2 are different from each other and are selected from the group of a C.sub.1 or C.sub.3 perfluoroalkyl group which may be interrupted by an oxygen atom, and a C.sub.5 -C.sub.7 perfluorocycloalkyl group, and n and n' are zero or an integer of 1; one of Rf.sub.1 and Rf.sub.2 being the C.sub.5 -C.sub.7 perfluorocycloalkyl group and the total number of carbon atoms being 9-11 inclusive.

摘要翻译： 具有下式的全氟醚化合物可用作热稳定的惰性溶剂，尤其用作人造血液或输注液中的氧载体。 其中Rf1和Rf2彼此不同，并且选自可被氧原子中断的C1或C3全氟烷基和C5-C7全氟环烷基，n和n'为零或 整数1; Rf1和Rf2之一是C5-C7全氟环烷基，碳原子总数为9-11（含）。

公开(公告)号：US4654337A

公开(公告)日：1987-03-31

申请号：US751880

申请日：1985-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  C07D223/00 ,  A61K31/435

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4425347A

公开(公告)日：1984-01-10

申请号：US454105

申请日：1982-12-28

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  A61K9/10 ,  A61K31/435 ,  A61P7/08 ,  B01F17/14 ,  C07D455/02

CPC分类号： C07D455/02 ,  A01N1/021 ,  A61K31/435 ,  Y10S514/832

摘要： A perfluorobicyclo compound emulsion preparation having oxygen carrying ability containing a perfluorobicyclo compound of the general formula: ##STR1## wherein R represents a perfluoromethyl group or perfluoroethyl group, as an oxygen carrying component.

摘要翻译： 一种全氟双环化合物乳液制剂，其具有含有下列通式的全氟二环化合物的氧承载能力：其中R表示全氟甲基或全氟乙基，作为携氧组分。

公开(公告)号：US4542147A

公开(公告)日：1985-09-17

申请号：US505322

申请日：1983-06-17

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  C07D209/94 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

摘要翻译： 一种下式的新化合物，其中k为0或1〜2的整数，j为1〜3的整数，l和m分别为0或1〜3的整数，n为 通过使与其对应的全氟化合物与氟反应来制备环A，B和C任选被至少一个三氟甲基或四氟乙基取代的整数。 该化合物可用作能够在水性乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内部器官。

公开(公告)号：US4423061A

公开(公告)日：1983-12-27

申请号：US454106

申请日：1982-12-28

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/107 ,  A61K31/40 ,  A61P7/08 ,  B01F17/14 ,  C07D207/10

CPC分类号： C07D207/10 ,  Y10S514/832

摘要： A perfluorocycloamine emulsion preparation having oxygen carrying ability containing a perfluorocycloamine of the general formula: ##STR1## wherein any position may optionally be substituted with a perfluoromethyl group as an oxygen carrying component.

摘要翻译： 一种全氟环丙胺乳液制剂，其具有含有以下通式的全氟环丙胺的含氧载体：其中任何位置可任选被全氟甲基取代为携氧组分。

公开(公告)号：US4604385A

公开(公告)日：1986-08-05

申请号：US751851

申请日：1985-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  A61K31/395 ,  A61K31/55

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4535085A

公开(公告)日：1985-08-13

申请号：US480131

申请日：1983-03-29

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： C07D209/58 ,  C07D209/72 ,  C07D221/22 ,  A61K31/445 ,  A61K31/40 ,  C07D221/16

CPC分类号： C07D209/58 ,  C07D209/72 ,  C07D221/22

摘要： A perfluorotricyclic amine compound which is usable as an oxygen carrier in an artificial blood, represented by the general formula ##STR1## wherein R denotes a perfluoroalkyl group having 1-4 carbon atoms; the ring A denotes a five- or six-membered ring, the ring B denotes a five-, six- or seven-membered ring, the ring C denotes a five- or six-membered ring any one of the rings A, B and C optionary being substituted by one or more lower perfluoroalkyl group in addition to the above-mentioned substituent R; and further f, g, h, i, j and k denote integers appropriately selected to construct the above-mentioned size of rings A, B, and C; is prepared by reacting the corresponding perhydrotricyclic amine with fluorine.

摘要翻译： 一种全氟三环胺化合物，其可用作人造血液中的氧载体，由通式表示，其中R表示具有1-4个碳原子的全氟烷基; 环A表示五元或六元环，环B表示五元，六元或七元环，环C表示环A，B和 除了上述取代基R外，C选自被一个或多个低级全氟烷基取代; 并且f，g，h，i，j和k表示适当选择以构成环A，B和C的上述尺寸的整数; 通过使相应的全氢三环胺与氟反应来制备。

公开(公告)号：US4605650A

公开(公告)日：1986-08-12

申请号：US751850

申请日：1983-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  A61K31/40

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4613605A

公开(公告)日：1986-09-23

申请号：US751948

申请日：1985-07-05

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A61K9/00 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  A61K31/445 ,  C07D453/00

CPC分类号： A61K9/0026 ,  C07D453/02 ,  C07D471/08 ,  C07D487/08 ,  C25B3/08 ,  Y10S514/832 ,  Y10S514/833

摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

公开(公告)号：US4530926A

公开(公告)日：1985-07-23

申请号：US505324

申请日：1983-06-17

申请人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

发明人： Kazumasa Yokoyama ,  Chikara Fukaya ,  Yoshio Tsuda ,  Taizo Ono ,  Yoshio Arakawa ,  Yoshihisa Inoue ,  Youichiro Naito ,  Tadakazu Suyama

IPC分类号： A01N1/02 ,  C07D455/03 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  A61K31/55 ,  A61K31/40 ,  A61K31/445 ,  C07D455/06

CPC分类号： C07D455/00 ,  A01N1/021 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

摘要： A novel compound of the formula, ##STR1## wherein k, j, l and m are zero or an integer of from 1 to 3, and n is an integer of from 1 to 3, the rings A, B and C being optionally substituted with at least one trifluoromethyl group, prepared by reacting the corresponding perhydro compound with fluorine is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

摘要翻译： 式（I）的新颖化合物，其中k，j，l和m为0或1〜3的整数，n为1〜3的整数，环A，B，C 任选地被至少一个三氟甲基取代，其通过使相应的全氢化合物与氟反应制备，可用作能够在水乳液中携带氧气的材料，用于挽救患有大量出血的患者和用于在移植中保存内脏。