公开(公告)号：US06828348B2

公开(公告)日：2004-12-07

申请号：US10479145

申请日：2003-11-25

申请人： Kazumi Ogata ,  Noriko Saito ,  Kazuhiko Yamada ,  Genta Maruyama

发明人： Kazumi Ogata ,  Noriko Saito ,  Kazuhiko Yamada ,  Genta Maruyama

IPC分类号： C07D31172

CPC分类号： C07H19/23 ,  C07D407/12

摘要： L-Ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester.1-propanol adduct or its pharmacologically acceptable salt; cosmetic components, antioxidants, radical scavengers, anti-inflammatory agents and elastase inhibitors containing the same as the active ingredient; and a process for producing the above-described adduct characterized by comprising extracting a solution containing L-ascorbic acid-2-O-maleic acid-&agr;-tocopherol diester with a solvent, distilling off the solvent, and adding to the residue 1-propanol mixed with an organic solvent followed by crystallization.

摘要翻译： L-抗坏血酸-2-O-马来酸-α-生育酚二酯-1-丙醇加合物或其药理学上可接受的盐; 化妆品组分，抗氧化剂，自由基清除剂，抗炎剂和含有与活性成分相同的弹性蛋白酶抑制剂; 以及制备上述加合物的方法，其特征在于包括用溶剂萃取含有L-抗坏血酸-2-O-马来酸-α-生育酚二酯的溶液，蒸除溶剂，并向残余物中加入1-丙醇 与有机溶剂混合，然后结晶。

公开(公告)号：US5474992A

公开(公告)日：1995-12-12

申请号：US302192

申请日：1994-08-31

申请人： Kazumi Ogata ,  Takahiro Sakaue ,  Noriko Saito ,  Sachiko Matsuura ,  Rie Nagao ,  Shinya Ogino

发明人： Kazumi Ogata ,  Takahiro Sakaue ,  Noriko Saito ,  Sachiko Matsuura ,  Rie Nagao ,  Shinya Ogino

IPC分类号： A61K31/665 ,  A61K33/12 ,  A61M1/16 ,  A61K31/355 ,  A61K31/66

CPC分类号： A61K31/665 ,  A61K33/12 ,  A61M1/1654

摘要： A pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis which comprise a phosphoric acid diester of the following formula: ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group) or a pharmacologically acceptable salt thereof.Since the composition of this invention inhibits the formation of free radicals in the body, it can be advantageously used for the prophylaxis and treatment of various renal disorders such as glomerulonephritis, acute renal failure, uremia, adriamycin nephrosis, puromycin nephrosis, gentamicin- and cisplatin-induced disorders of the kidney, renal impairment due to paraquat and other agricultural chemicals, and immune complex nephritis. Moreover, the composition of this invention is also of use as a dialysis solution for extracorporeal hemodialysis with the propylactic/therapeutic effect on dialysis amyloidosis.

摘要翻译： 一种用于肾脏疾病的药物组合物和用于体外血液透析的透析溶液，其包含下式的磷酸二酯：其中R 1和R 2相同或不同，各自表示氢原子或甲基）或 其药理学上可接受的盐。 由于本发明的组合物抑制体内自由基的形成，因此可有利地用于预防和治疗各种肾脏疾病如肾小球性肾炎，急性肾功能衰竭，尿毒症，阿霉素肾病，嘌呤霉素肾病，庆大霉素和顺铂 诱发的肾脏疾病，百草枯和其他农药引起的肾损伤和免疫复合性肾炎。 此外，本发明的组合物也可用作体外血液透析的透析溶液，具有对透析性淀粉样变性的丙糖/治疗作用。

公开(公告)号：US5750516A

公开(公告)日：1998-05-12

申请号：US724509

申请日：1996-09-30

申请人： Masayuki Nakamura ,  Kazumi Ogata ,  Takahiro Sakaue ,  Noriko Saito ,  Masahito Iemura

发明人： Masayuki Nakamura ,  Kazumi Ogata ,  Takahiro Sakaue ,  Noriko Saito ,  Masahito Iemura

IPC分类号： A61K8/67 ,  A61Q17/04 ,  A61Q19/00 ,  C07F9/655 ,  C07F9/6558 ,  A61K31/665 ,  A61K31/355 ,  C07F9/06 ,  C07F9/28

CPC分类号： A61Q19/00 ,  A61K8/676 ,  A61K8/678 ,  C07F9/65522 ,  C07F9/65586 ,  A61K2800/522 ,  A61Q17/04

摘要： This invention provides a phosphoric diester of formula (I) which is available on di-esterification of phosphoric acid with L-ascorbic acid involving its 5-hydroxyl group and tocopherol involving its hydroxyl group or a pharmacologically acceptable salt thereof. ##STR1## The compound of the invention can be used with advantage as an antioxidant (radical-scavenging) agent and a prophylactic and therapeutic agent for ischemic organ disorders (e.g. myocardial infarction, heart failure, arrhythmia, cerebral infarction, stroke (cerebral apoplexy), renal failure, etc.).

摘要翻译： 本发明提供式（I）的磷酸二酯，其可以在涉及其5-羟基和涉及其羟基的生育酚或其药学上可接受的盐的磷酸与L-抗坏血酸二酯化的情况下得到。 （I）本发明的化合物可以作为抗氧化剂（自由基清除剂）和缺血性器官功能障碍的预防和治疗剂（例如心肌梗塞，心力衰竭，心律失常，脑梗塞，中风（ 脑中风），肾衰竭等）。

公开(公告)号：US08822503B2

公开(公告)日：2014-09-02

申请号：US13081201

申请日：2011-04-06

申请人： Takanori Kawaguchi ,  Kengo Watatani ,  Keiko Fusegi ,  Masahiro Bohno ,  Hajime Asanuma ,  Shoichi Kuroda ,  Yudai Imai ,  Tomomichi Chonan ,  Nagaaki Sato ,  Shigeru Tokita ,  Shigetada Sasako ,  Takumi Okada ,  Keishi Hayashi ,  Shin Itoh ,  Noriko Saito ,  Rui Jibiki ,  Seishi Ishiyama ,  Hirofumi Ota

发明人： Takanori Kawaguchi ,  Kengo Watatani ,  Keiko Fusegi ,  Masahiro Bohno ,  Hajime Asanuma ,  Shoichi Kuroda ,  Yudai Imai ,  Tomomichi Chonan ,  Nagaaki Sato ,  Shigeru Tokita ,  Shigetada Sasako ,  Takumi Okada ,  Keishi Hayashi ,  Shin Itoh ,  Noriko Saito ,  Rui Jibiki ,  Seishi Ishiyama ,  Hirofumi Ota

IPC分类号： A61K31/4439 ,  C07D401/06

CPC分类号： C07D401/10 ,  C07D213/64 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： A 2-pyridone compound represented by the formula [1]: {wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

摘要翻译： 由式[1]表示的2-吡啶酮化合物：其中，在式[1]中，由A表示的环表示苯环或吡啶环，X表示由式[3]表示的任何结构 V表示单键或低级亚烷基，W表示单键，醚键或低级亚烷基（其中低级亚烷基可以含有醚键）}，化合物的互变异构体或立体异构体， 其药学上可接受的盐或其溶剂合物是具有优异的GK活化作用并可用作药物的化合物。

公开(公告)号：US07099667B2

公开(公告)日：2006-08-29

申请号：US10115921

申请日：2002-04-05

申请人： Noriko Saito ,  Roi Fujita

发明人： Noriko Saito ,  Roi Fujita

IPC分类号： H04Q7/20

CPC分类号： H04B1/70755 ,  H04B1/712

摘要： The present invention uses site diversity reception and RAKE combining reception for the method for a CDMA communication mobile terminal to carry out a cell search to search for a base station with which to communicate. Even if the reception power levels of synchronization acquisition signals sent from a plurality of base stations are lower than a predetermined threshold, in the case where the power level of a signal combining those signals is equal to or greater than the predetermined threshold, the mobile terminal continues processing of requesting position registration to any one of the plurality of base stations and thereby improves communicability.

公开(公告)号：US07780291B2

公开(公告)日：2010-08-24

申请号：US12048024

申请日：2008-03-13

申请人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

发明人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

IPC分类号： A61B3/10

CPC分类号： G02B26/06 ,  A61B3/1015 ,  A61B3/14 ,  G02B26/0825

摘要： A wavefront aberration compensating apparatus includes: a deformable mirror which compensates a wavefront aberration of a light flux entered, the deformable mirror including a plurality of electrodes, and a thin-film mirror which changes a configuration thereof in accordance with a voltage value applied to each of the electrodes; an optical system provided with the deformable mirror, and including an object subjected to aberration compensation; a wavefront sensor which receives the light flux traveled through the object and the deformable mirror, and which measures the wavefront aberration of the light flux; and a controller configured to calculate the voltage value applied to each of the electrodes, on the basis of differences, from a signal outputted from the wavefront sensor, between application points on the thin-film mirror and target points both corresponding to the electrodes, respectively, and to repeat compensation of the configuration of the thin-film mirror of the deformable mirror on the basis of the calculated voltage value, such that the wavefront aberration of the light flux measured by the wavefront sensor is suppressed.

摘要翻译： 波前像差补偿装置包括：可变形反射镜，其补偿进入的光束的波前像差，可变形反射镜包括多个电极;以及薄膜反射镜，其根据施加到每个的电压值来改变其配置 的电极; 设置有可变形反射镜的光学系统，并且包括经受像差补偿的物体; 接收通过物体和可变形反射镜行进的光束并测量光通量的波前像差的波前传感器; 以及控制器，被配置为基于差异来计算施加到每个电极的电压值，所述电压值分别来自所述波前传感器输出的信号，在所述薄膜反射镜上的应用点和对应于所述电极的目标点​​之间 并且基于所计算的电压值重复对可变形反射镜的薄膜反射镜的配置的补偿，使得由波前传感器测量的光通量的波前像差被抑制。

公开(公告)号：US5271926A

公开(公告)日：1993-12-21

申请号：US853996

申请日：1992-03-19

申请人： Naohisa Kure ,  Noriko Saito ,  Yuji Hirano

发明人： Naohisa Kure ,  Noriko Saito ,  Yuji Hirano

IPC分类号： A61K8/00 ,  A61K8/44 ,  A61K8/73 ,  A61K8/81 ,  A61K8/92 ,  A61Q5/00 ,  A61Q5/06 ,  A61Q5/12 ,  C08L83/08 ,  A61K7/075

CPC分类号： A61K8/44 ,  A61K8/731 ,  A61K8/817 ,  A61Q5/06 ,  A61K2800/5426 ,  A61K2800/88

摘要： A two-pack hair treatment composition comprising a first lotion containing a reducing substance (a) and a cationic polymer (b) and a second lotion containing an anionic surfactant or amphoteric surfactant (c) and a lubricant (d), wherein the first lotion is applied to the hair first and then the second lotion is applied thereto.The process of the present invention for treating the hair with the above-described two-pack hair treatment composition comprises treating the hair with the first lotion, leaving the hair to stand for a predetermined period of time and, if necessary, subjecting it to intermediate rinsing, applying the second lotion to the hair, leaving the hair stand again for a predetermined period of time, and finally rinsing the hair.

公开(公告)号：US07537341B2

公开(公告)日：2009-05-26

申请号：US12048095

申请日：2008-03-13

申请人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

发明人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

IPC分类号： A61B3/10 ,  A61B3/14 ,  A61B3/00

CPC分类号： G02B26/06 ,  A61B3/1015 ,  A61B3/14 ,  G02B26/0825

摘要： A wavefront aberration compensating apparatus, which includes: a deformable mirror having electrodes and a thin-film mirror; an optical system provided with the deformable mirror and including an object; a wavefront sensor which measures a wavefront aberration of a light flux; and a controller configured to: calculate a first voltage value applied to each of the electrodes, on the basis of differences between application points on the thin-film mirror and target points both corresponding to the electrodes respectively; determine a superposition amplitude value of each expansion mode according to a polynomial of wavefront aberration, and calculate a second voltage value applied to each of the electrodes by using voltage templates previously stored, such that the wavefront aberration obtained by the wavefront sensor becomes a desired aberration; determine the voltage value applied to each of the electrodes, by mainly using the second voltage value in an initial stage of compensation of the configuration of the thin-film mirror and by mainly using the first voltage value in an end stage of the compensation; and repeat the compensation on the basis of the determined voltage value, such that the wavefront aberration of the light flux is suppressed.

摘要翻译： 一种波前像差补偿装置，包括：具有电极和薄膜反射镜的可变形反射镜; 设置有可变形反射镜并包括物体的光学系统; 测量光通量的波前像差的波前传感器; 以及控制器，其被配置为：基于薄膜反射镜上的应用点和分别对应于电极的目标点​​之间的差异来计算施加到每个电极的第一电压值; 根据波前像差的多项式确定每个扩展模式的叠加振幅值，并且通过使用预先存储的电压模板来计算施加到每个电极的第二电压值，使得由波前传感器获得的波前像差成为期望的像差 ; 通过在补偿薄膜反射镜的构造的初始阶段主要使用第二电压值，并且主要在补偿的最后阶段使用第一电压值来确定施加到每个电极的电压值; 并根据确定的电压值重复补偿，从而抑制光通量的波前像差。

公开(公告)号：US07520613B2

公开(公告)日：2009-04-21

申请号：US12047946

申请日：2008-03-13

申请人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

发明人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

IPC分类号： A61B3/10 ,  A61B3/14

CPC分类号： G02B26/06 ,  A61B3/1015 ,  A61B3/12

摘要： A wavefront aberration compensating apparatus, including: a deformable mirror which compensates a wavefront aberration of a light flux and includes electrodes, and a thin-film mirror which changes a configuration thereof in accordance with a voltage value applied to each of the electrodes; an optical system provided with the deformable mirror and including an object subjected to aberration compensation; a wavefront sensor which measures the wavefront aberration of the light flux; a memory which stores therein a voltage template provided for each expansion mode according to a polynomial of wavefront aberration, as a voltage alignment data for the electrodes which induces the corresponding expansion mode; and a controller configured to determine a superposition amplitude value of each of the expansion modes and calculate the voltage value applied to each of the electrodes by using the voltage templates stored such that the wavefront aberration obtained by the wavefront sensor becomes a desired aberration, and to repeat compensation of the configuration of the thin-film mirror on the basis of the calculated voltage value, such that the wavefront aberration of the light flux measured by the wavefront sensor is suppressed.

摘要翻译： 一种波前像差补偿装置，包括：可变形反射镜，其补偿光束的波前像差并包括电极;以及薄膜反射镜，其根据施加到每个电极的电压值改变其配置; 设置有可变形反射镜并包括经受像差补偿的物体的光学系统; 测量光通量波前像差的波前传感器; 存储器，其中存储根据波前像差的多项式为每个扩展模式提供的电压模板作为引起相应扩展模式的电极的电压对准数据; 以及控制器，被配置为确定每个扩展模式的叠加振幅值，并且通过使用存储的电压模板来计算施加到每个电极的电压值，使得由波前传感器获得的波前像差成为期望的像差，并且 基于计算出的电压值重复补偿薄膜反射镜的结构，从而抑制由波前传感器测量的光通量的波前像差。

公开(公告)号：US20080225228A1

公开(公告)日：2008-09-18

申请号：US12047946

申请日：2008-03-13

申请人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

发明人： Noriko Saito ,  Akio Kobayashi ,  Hiroyuki Kawashima

IPC分类号： A61B3/14 ,  G02B7/188 ,  A61B3/10

CPC分类号： G02B26/06 ,  A61B3/1015 ,  A61B3/12

摘要： A wavefront aberration compensating apparatus, including: a deformable mirror which compensates a wavefront aberration of a light flux and includes electrodes, and a thin-film mirror which changes a configuration thereof in accordance with a voltage value applied to each of the electrodes; an optical system provided with the deformable mirror and including an object subjected to aberration compensation; a wavefront sensor which measures the wavefront aberration of the light flux; a memory which stores therein a voltage template provided for each expansion mode according to a polynomial of wavefront aberration, as a voltage alignment data for the electrodes which induces the corresponding expansion mode; and a controller configured to determine a superposition amplitude value of each of the expansion modes and calculate the voltage value applied to each of the electrodes by using the voltage templates stored such that the wavefront aberration obtained by the wavefront sensor becomes a desired aberration, and to repeat compensation of the configuration of the thin-film mirror on the basis of the calculated voltage value, such that the wavefront aberration of the light flux measured by the wavefront sensor is suppressed.

摘要翻译： 一种波前像差补偿装置，包括：可变形反射镜，其补偿光束的波前像差并包括电极;以及薄膜反射镜，其根据施加到每个电极的电压值改变其结构; 设置有可变形反射镜并包括经受像差补偿的物体的光学系统; 测量光通量波前像差的波前传感器; 存储器，其中存储根据波前像差的多项式为每个扩展模式提供的电压模板作为引起相应扩展模式的电极的电压对准数据; 以及控制器，被配置为确定每个扩展模式的叠加振幅值，并且通过使用存储的电压模板来计算施加到每个电极的电压值，使得由波前传感器获得的波前像差成为期望的像差，并且 基于计算出的电压值重复补偿薄膜反射镜的结构，从而抑制由波前传感器测量的光通量的波前像差。