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公开(公告)号：US08871484B2
公开(公告)日：2014-10-28
申请号：US13128323
申请日：2009-11-12
CPC分类号： C12N9/88 , C12Y402/01084
摘要： A nitrile hydratase variant of the present invention comprises substitution of at least one amino acid with another amino acid to improve two or more properties of nitrile hydratase by substitution of one amino acid.
摘要翻译： 本发明的腈水合酶突变体包括用另一个氨基酸取代至少一个氨基酸，以通过取代一个氨基酸改善腈水合酶的两个或更多个性质。
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公开(公告)号：US20110212506A1
公开(公告)日：2011-09-01
申请号：US13128323
申请日：2009-11-12
CPC分类号： C12N9/88 , C12Y402/01084
摘要： A nitrile hydratase variant of the present invention comprises substitution of at least one amino acid with another amino acid to improve two or more properties of nitrile hydratase by substitution of one amino acid.
摘要翻译： 本发明的腈水合酶突变体包括用另一个氨基酸取代至少一个氨基酸，以通过取代一个氨基酸改善腈水合酶的两个或更多个性质。
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公开(公告)号：US07402710B2
公开(公告)日：2008-07-22
申请号：US10594731
申请日：2005-03-28
申请人： Kazuya Matsumoto , Yasushi Kazuno , Norikazu Higashimura , Toshihisa Ohshima , Haruhiko Sakuraba
发明人： Kazuya Matsumoto , Yasushi Kazuno , Norikazu Higashimura , Toshihisa Ohshima , Haruhiko Sakuraba
IPC分类号： C07C45/72
摘要： An industrial process for producing hydroxyaldehydes efficiently, by solving the problems of conventional DERA, such as low stability against aldehydes, low catalytic activity for aldol condensation, and the difficulty of controlling the number of acetaldehyde molecules to be condensed, is provided.According to the process, aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with acetaldehyde is conducted by using D-2-deoxyribose-5-phosphate aldolase which is highly stable against aldehydes and has high catalytic activity for aldol condensation, whereby a hydroxyaldehyde compound having the number of carbon atoms increased by two or four can be produced.
摘要翻译： 提供了通过解决常规DERA的问题，例如对醛的低稳定性，醛醇缩合的低催化活性和难以控制缩合的乙醛分子的数量来有效生产羟醛的工业方法。 根据该方法，取代或未取代的具有2-6个碳原子的脂族醛化合物与乙醛的醛醇缩合通过使用对醛高度稳定的D-2-脱氧核糖-5-磷酸醛缩酶进行，并且对于醛醇具有高催化活性 缩合，由此可以制备碳原子数增加2或4的羟基醛化合物。
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公开(公告)号：US20070196906A1
公开(公告)日：2007-08-23
申请号：US10594731
申请日：2005-03-28
申请人： Kazuya Matsumoto , Yasushi Kazuno , Norikazu Higashimura , Toshihisa Ohshima , Haruhiko Sakuraba
发明人： Kazuya Matsumoto , Yasushi Kazuno , Norikazu Higashimura , Toshihisa Ohshima , Haruhiko Sakuraba
IPC分类号： C12P7/24
摘要： An industrial process for producing hydroxyaldehydes efficiently, by solving the problems of conventional DERA, such as low stability against aldehydes, low catalytic activity for aldol condensation, and the difficulty of controlling the number of acetaldehyde molecules to be condensed, is provided. According to the process, aldol condensation of a substituted or unsubstituted aliphatic aldehyde compound having 2 to 6 carbon atoms with acetaldehyde is conducted by using D-2-deoxyribose-5-phosphate aldolase which is highly stable against aldehydes and has high catalytic activity for aldol condensation, whereby a hydroxyaldehyde compound having the number of carbon atoms increased by two or four can be produced.
摘要翻译： 提供了通过解决常规DERA的问题，例如对醛的低稳定性，醛醇缩合的低催化活性和难以控制缩合的乙醛分子的数量来有效生产羟醛的工业方法。 根据该方法，取代或未取代的具有2-6个碳原子的脂族醛化合物与乙醛的醛醇缩合通过使用对醛高度稳定的D-2-脱氧核糖-5-磷酸醛缩酶进行，并且对于醛醇具有高催化活性 缩合，由此可以制备碳原子数增加2或4的羟基醛化合物。
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