公开(公告)号：US20110236262A1

公开(公告)日：2011-09-29

申请号：US13071142

申请日：2011-03-24

申请人： Kazuyoshi HORII ,  Tomonari Sendai ,  Akihiro Komatsu ,  Mitsuaki Uchida ,  Masashi Hakamata ,  Junpei Shiraishi ,  Daisuke Hibe ,  Yasunori Ohta ,  Akira Ito

发明人： Kazuyoshi HORII ,  Tomonari Sendai ,  Akihiro Komatsu ,  Mitsuaki Uchida ,  Masashi Hakamata ,  Junpei Shiraishi ,  Daisuke Hibe ,  Yasunori Ohta ,  Akira Ito

IPC分类号： B01J19/00

CPC分类号： G01N21/648 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/143 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/082

摘要： A biological substance detecting apparatus that enables stable detection and quantitative analysis of biologically derived target substances is provided. The biological substance detecting apparatus employs a sensor chip provided with a fine flow channel through which a sample liquid is caused to flow, and a sensor surface that adsorbs a biologically derived target substance. Light is irradiated onto the sensor surface, and light emitted by the adsorbed target substance or a labeling substance bound thereto is detected. A flow speed controlling means, for controlling the flow speed of the sample liquid that flows through the fine flow channel to a value within a range such that the adsorption speed of the target substance is not controlled by dispersion.

摘要翻译： 提供一种能够对生物衍生的靶物质进行稳定检测和定量分析的生物物质检测装置。 生物物质检测装置采用设置有流过样品液的微细流路的传感器芯片和吸附生物衍生的靶物质的传感器表面。 光照射到传感器表面上，并且检测被吸附的目标物质发出的光或与其结合的标记物质。 一种流量控制装置，用于将流过细流动通道的样品液体的流速控制在使得目标物质的吸附速度不受分散控制的范围内的值。

公开(公告)号：US08749787B2

公开(公告)日：2014-06-10

申请号：US13045361

申请日：2011-03-10

申请人： Junpei Shiraishi ,  Masashi Hakamata

发明人： Junpei Shiraishi ,  Masashi Hakamata

IPC分类号： G01N21/00

CPC分类号： G01N21/648 ,  G01N21/6428

摘要： Excitation light beam is irradiated onto a test region while shifting the irradiation position thereof, when performing analysis of a target substance using an analysis chip having the test region within a flow channel through which a sample solution is caused to flow, for capturing the target substance within the sample solution. Fluorescence generated at the test region is detected as a plurality of adjustment fluorescence signals. The target substance is analyzed using fluorescence generated when the excitation light beam is irradiated at an irradiation position within the test region determined based on the plurality of adjustment fluorescence signals.

摘要翻译： 激发光束在移动其照射位置的同时照射到测试区域上，当使用具有测试区域的分析芯片进行目标物质的分析时，所述测试区域在通过其的样品溶液流过的流动通道内，用于捕获目标物质 在样品溶液中。 在测试区域产生的荧光被检测为多个调节荧光信号。 使用在基于多个调整荧光信号确定的测试区域内的照射位置照射激发光束时产生的荧光来分析目标物质。

公开(公告)号：US20100101652A1

公开(公告)日：2010-04-29

申请号：US12532050

申请日：2008-03-14

申请人： Junpei Shiraishi

发明人： Junpei Shiraishi

IPC分类号： F15D1/00 ,  G01N35/10

CPC分类号： G01N35/1095 ,  G01N2035/103 ,  Y10T137/0318

摘要： A pipette chip has an opening section to be inserted into a supply port of a liquid channel, which connects the supply port and a discharge port of a liquid, and reserves the liquid to be supplied to the liquid channel. In a liquid feeding apparatus, the pipette chip is controlled to insert the opening section into the supply port. Suction and discharge of the liquid and a gas in the pipette chip are controlled to form an air layer at the opening section by sucking the air from the opening section before inserting the opening section into the supply port.

摘要翻译： 移液管芯片具有插入到液体通道的供给口中的开口部分，该液体通道连接供给口和液体的排出口，并且储存供应到液体通道的液体。 在液体供给装置中，移液管芯片被控制以将开口部分插入供给口。 通过在将开口部插入供给口之前，从开口部抽吸空气，控制吸液管芯中的液体和气体的吸入和排出，以在开口部分形成空气层。

公开(公告)号：US20060157526A1

公开(公告)日：2006-07-20

申请号：US11332701

申请日：2006-01-17

申请人： Junpei Shiraishi ,  Jun Matsunaga

发明人： Junpei Shiraishi ,  Jun Matsunaga

IPC分类号： B65H20/00

CPC分类号： B65H16/02 ,  B65H2301/415185 ,  B65H2301/522 ,  B65H2801/12

摘要： A motor is driven according to a total feeding amount of a recording paper calculated based on the number of prints. When a gear is rotated in a counterclockwise direction, an end of a coil spring is moved upward and a retaining arm is rotated. A tip of a separation plate fixed to the retaining arm is moved to a contact position in which the tip contacts an outer peripheral surface of a paper roll. The separation plate presses the outer peripheral surface with a constant pressing force by a coil spring. When the paper roll is rotated, the separation plate separates a paper end. Thereafter, the gear is rotated in a clockwise direction to move the end of the coil spring downward so that the separation plate moves to a retracting position away from the outer peripheral surface. During printing, the separation plate is in the retracting position.

摘要翻译： 根据基于打印数量计算的记录纸的总进给量来驱动电动机。 当齿轮沿逆时针方向旋转时，螺旋弹簧的端部向上移动并且保持臂旋转。 固定在保持臂上的分离板的前端移动到接触位置，在该接触位置，尖端接触纸卷的外周面。 分离板通过螺旋弹簧以恒定的压力推压外周面。 当纸卷旋转时，分隔板分隔纸张端。 此后，齿轮沿顺时针方向旋转，以向下移动螺旋弹簧的端部，使得分离板移动到离开外周表面的缩回位置。 在打印期间，分离板处于缩回位置。