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公开(公告)号：US20150024018A1
公开(公告)日：2015-01-22
申请号：US14281682
申请日：2014-05-19
摘要： A material including a plurality of fatty acid chains cross-linked together and a silver fatty acid salt formed with the fatty acid chains within the material. Methods for forming a material are also included. The silver-containing materials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents.
摘要翻译： 包括交联在一起的多个脂肪酸链和与材料内的脂肪酸链形成的银脂肪酸盐的材料。 还包括形成材料的方法。 含银材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种抗感染剂。
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公开(公告)号：US20110038910A1
公开(公告)日：2011-02-17
申请号：US12539282
申请日：2009-08-11
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of loading them with silver compounds are described. The silver-containing biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译： 描述了脂肪酸衍生的生物材料，制备生物材料的方法以及用银化合物加载它们的方法。 含银生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种抗感染剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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公开(公告)号：US20090208552A1
公开(公告)日：2009-08-20
申请号：US12364763
申请日：2009-02-03
申请人： Keith M. FAUCHER , Hui TANG , Paul MARTAKOS , Steve A. HERWECK , Theodore KARWOSKI , Allison SULLIVAN , Greg MELVILLE , Scott E. CORBEIL
发明人： Keith M. FAUCHER , Hui TANG , Paul MARTAKOS , Steve A. HERWECK , Theodore KARWOSKI , Allison SULLIVAN , Greg MELVILLE , Scott E. CORBEIL
IPC分类号： A61K9/00 , A61K47/44 , C07C53/00 , C07D307/02 , A61K38/13 , A61K31/4353 , B05D3/00 , A61P37/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2250/0067 , A61K31/4353 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61L2420/06 , A61L2430/00
摘要： Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译： 描述了基于脂肪酸的预固化衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。 脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。 还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。
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公开(公告)号：US20100183697A1
公开(公告)日：2010-07-22
申请号：US12581582
申请日：2009-10-19
申请人： Thomas M. SWANICK , Joe BIENKIEWICZ , Joseph FERRARO , Paul MARTAKOS , Keith M. FAUCHER , Alicia DALE
发明人： Thomas M. SWANICK , Joe BIENKIEWICZ , Joseph FERRARO , Paul MARTAKOS , Keith M. FAUCHER , Alicia DALE
CPC分类号： A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要： Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
摘要翻译： 本发明的示例性实施方案提供了具有抗粘连和组织固定性质的粘合屏障。 粘合屏障由脂肪酸基膜形成。 脂肪酸基膜可以由脂肪酸衍生的生物材料形成。 膜可以涂覆或可以包括组织固定材料以产生粘合屏障。 粘附屏障由身体良好耐受，具有抗炎特性，固定到组织上，并具有足以防止手术后粘连的停留时间。
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