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    Novel heteroaryl derivative
    1.
    发明申请
    Novel heteroaryl derivative 失效
    新型杂芳基衍生物

    公开(公告)号：US20060194857A1

    公开(公告)日：2006-08-31

    申请号：US10563361

    申请日：2004-07-13

    申请人： Ken-ichi Watanabe ,  Katsunori Maruta ,  Kantaro Ushiroda ,  Ryu Nagata

    发明人： Ken-ichi Watanabe ,  Katsunori Maruta ,  Kantaro Ushiroda ,  Ryu Nagata

    IPC分类号： A61K31/4196 ,  A61K31/4172 ,  A61K31/401 ,  A61K31/415

    CPC分类号： C07D207/333

    摘要： A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, —NR10—, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 式（1）的杂芳基衍生物：（其中环Z是任选取代的杂芳基，R 1是羧基或烷氧基羰基等，W 1， 和W 2是任选取代的低级亚烷基，Ar 1是任选取代的亚芳基或任选取代的亚杂芳基，W 3是单键 ，低级亚烷基，低级亚烯基等，W 4是单键，-NR 10 - 等，Ar 2， 是任选取代的芳基或任选取代的杂芳基）或其前药，或其药学上可接受的盐。

    NOVEL HETEROARYL DERIVATIVE
    2.
    发明申请
    NOVEL HETEROARYL DERIVATIVE 审中-公开
    新世代衍生

    公开(公告)号：US20080306275A1

    公开(公告)日：2008-12-11

    申请号：US12173792

    申请日：2008-07-15

    申请人： Ken-ichi WATANABE ,  Katsunori Maruta ,  Kantaro Ushiroda ,  Ryu Nagata

    发明人： Ken-ichi WATANABE ,  Katsunori Maruta ,  Kantaro Ushiroda ,  Ryu Nagata

    IPC分类号： C07D233/58 ,  C07D401/14

    CPC分类号： C07D207/333

    摘要： A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, —NR10—, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 式（1）的杂芳基衍生物：（其中环Z是任选取代的杂芳基，R 1是羧基或烷氧基羰基等，W 1和W 2是任选取代的低级亚烷基，Ar 1是任选取代的亚芳基或 任选取代的杂亚芳基，W3是单键，低级亚烷基，低级亚烯基等，W4是单键，-NR10-等，Ar2是任选取代的芳基或任选取代的杂芳基）或 前药，或其药学上可接受的盐。

    Heteroaryl derivative
    3.
    发明授权
    Heteroaryl derivative 失效
    杂芳基衍生物

    公开(公告)号：US07425642B2

    公开(公告)日：2008-09-16

    申请号：US10563361

    申请日：2004-07-13

    申请人： Ken-ichi Watanabe ,  Katsunori Maruta ,  Kantaro Ushiroda ,  Ryu Nagata

    发明人： Ken-ichi Watanabe ,  Katsunori Maruta ,  Kantaro Ushiroda ,  Ryu Nagata

    IPC分类号： C07D207/00 ,  C07D295/00

    CPC分类号： C07D207/333

    摘要： A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, —NR10—, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 式（1）的杂芳基衍生物：（其中环Z是任选取代的杂芳基，R 1是羧基或烷氧基羰基等，W 1， 和W 2是任选取代的低级亚烷基，Ar 1是任选取代的亚芳基或任选取代的亚杂芳基，W 3是单键 ，低级亚烷基，低级亚烯基等，W 4是单键，-NR 10 - 等，Ar 2， 是任选取代的芳基或任选取代的杂芳基）或其前药，或其药学上可接受的盐。

    Heteroaryl derivatives
    5.
    发明授权
    Heteroaryl derivatives 失效
    杂芳基衍生物

    公开(公告)号：US07781479B2

    公开(公告)日：2010-08-24

    申请号：US11795147

    申请日：2006-01-12

    申请人： Yoko Takahashi ,  Ryu Nagata ,  Kantaro Ushiroda

    发明人： Yoko Takahashi ,  Ryu Nagata ,  Kantaro Ushiroda

    IPC分类号： A61K31/405 ,  A61K31/404 ,  A61K31/192 ,  C07D209/04 ,  C07D209/12

    CPC分类号： C07D233/64 ,  C07D209/12 ,  C07D231/56 ,  C07D235/12 ,  C07D471/04

    摘要： A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.

    摘要翻译： 下式（1）的化合物或其前药或药学上可接受的盐可用作糖尿病药物或预防性或血糖调节剂或高脂血症治疗剂等，其中环Z为任选取代的杂芳基 W4为单键，低级亚烷基等，Ar2为任意取代的芳基等，W3为单键，低级亚烷基等，Ar1为任意取代的亚芳基等，W1，W2分别为 是任选取代的低级亚烷基等，并且R 1是羧基，烷氧基羰基。