公开(公告)号：US20100120693A1

公开(公告)日：2010-05-13

申请号：US12691125

申请日：2010-01-21

申请人： Kenji OKAJIMA ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

发明人： Kenji OKAJIMA ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

IPC分类号： A61K38/16 ,  A61P35/00

CPC分类号： A61K38/4866

摘要： A medicament for improving prognostic survival in therapy of malignant tumor is provided that may improve prognostic survival in DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. The medicament according to the invention comprises as a main active ingredient Activated Protein C, which is obtained from plasma or prepared by using the genetic recombination technique, and efficiently prolongs life-span of DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. In particular, the medicament may reduce adverse side effects of chemotherapeutics in chemotherapy of malignant tumor to enhance efficacy of said therapy and improve prognostic survival of patients suffering from malignant tumor.

摘要翻译： 提供了一种用于改善恶性肿瘤治疗预后生存的药物，可以改善基底疾病是恶性肿瘤，特别是造血器官恶性肿瘤的DIC患者的预后生存。 根据本发明的药物包含作为主要活性成分的由血浆获得或通过使用遗传重组技术制备的活化蛋白C，并有效延长了基础疾病是恶性肿瘤，特别是恶性肿瘤的DIC患者的寿命 在造血器官。 特别地，药物可以减少化学治疗剂在恶性肿瘤化疗中的不良副作用，以增强所述治疗的疗效并改善恶性肿瘤患者的预后。

公开(公告)号：US20080182791A1

公开(公告)日：2008-07-31

申请号：US12035936

申请日：2008-02-22

申请人： Kenji Okajima ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

发明人： Kenji Okajima ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

IPC分类号： A61K38/16 ,  A61P35/00

CPC分类号： A61K38/4866

摘要： A medicament for improving prognostic survival in therapy of malignant tumor is provided that may improve prognostic survival in DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. The medicament according to the invention comprises as a main active ingredient Activated Protein C, which is obtained from plasma or prepared by using the genetic recombination technique, and efficiently prolongs life-span of DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. In particular, the medicament may reduce adverse side effects of chemotherapeutics in chemotherapy of malignant tumor to enhance efficacy of said therapy and improve prognostic survival of patients suffering from malignant tumor.

摘要翻译： 提供了一种用于改善恶性肿瘤治疗预后生存的药物，可以改善基底疾病是恶性肿瘤，特别是造血器官恶性肿瘤的DIC患者的预后生存。 根据本发明的药物包含作为主要活性成分的由血浆获得或通过使用遗传重组技术制备的活化蛋白C，并有效延长了基础疾病是恶性肿瘤，特别是恶性肿瘤的DIC患者的寿命 在造血器官。 特别地，药物可以减少化学治疗剂在恶性肿瘤化疗中的不良副作用，以增强所述治疗的疗效并改善恶性肿瘤患者的预后。

公开(公告)号：US20060094650A1

公开(公告)日：2006-05-04

申请号：US10540852

申请日：2003-12-26

申请人： Kenji Okajima ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

发明人： Kenji Okajima ,  Fujio Matsuo ,  Hiroyuki Sutoh ,  Yoichi Ogata ,  Tomohiro Nakagaki

IPC分类号： A61K38/17

CPC分类号： A61K38/4866

摘要： A medicament for improving prognostic survival in therapy of malignant tumor is provided that may improve prognostic survival in DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. The medicament according to the invention comprises as a main active ingredient Activated Protein C, which is obtained from plasma or prepared by using the genetic recombination technique, and efficiently prolongs life-span of DIC patients where the basal disease is malignant tumor, especially malignant tumor in hematopoietic organs. In particular, the medicament may reduce adverse side effects of chemotherapeutics in chemotherapy of malignant tumor to enhance efficacy of said therapy and improve prognostic survival of patients suffering from malignant tumor.

摘要翻译： 提供了一种用于改善恶性肿瘤治疗预后生存的药物，可以改善基底疾病是恶性肿瘤，特别是造血器官恶性肿瘤的DIC患者的预后生存。 根据本发明的药物包含作为主要活性成分的由血浆获得或通过使用遗传重组技术制备的活化蛋白C，并有效延长了基础疾病是恶性肿瘤，特别是恶性肿瘤的DIC患者的寿命 在造血器官。 特别地，药物可以减少化学治疗剂在恶性肿瘤化疗中的不良副作用，以增强所述治疗的疗效并改善恶性肿瘤患者的预后。

公开(公告)号：US5962299A

公开(公告)日：1999-10-05

申请号：US633834

申请日：1996-04-29

申请人： Kazumasa Miyata ,  Yoshinori Akimoto ,  Yoichi Ogata ,  Tomohiro Nakagaki

发明人： Kazumasa Miyata ,  Yoshinori Akimoto ,  Yoichi Ogata ,  Tomohiro Nakagaki

IPC分类号： A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  C12N9/64 ,  C12N9/96 ,  C12N9/48

CPC分类号： C12N9/6464 ,  A61K38/4866 ,  C12N9/96 ,  C12Y304/21069

摘要： A method for stabilizing protein C or activated protein C and a preparation obtained by said method are provided, said method and preparation being applicable during procedures such as isolation and purification, lyophilization, heating, etc. or when stored.To a salt buffer containing protein C or activated protein C and sodium ion are added at least one amino acids, and further either one or a combination of albumin and a non-ionic surfactant.

摘要翻译： PCT No.PCT / JP94 / 01804 Sec。 371日期：1996年4月23日 102（e）日期1996年4月23日PCT 1994年10月27日PCT公布。 WO95 / 11698 PCT公开号 日期1995年5月4日提供了一种用于稳定蛋白C或活化蛋白C的方法和通过所述方法获得的制剂，所述方法和制剂适用于分离和纯化，冻干，加热等过程中或当储存时。 向含有蛋白质C或活化蛋白C和钠离子的盐缓冲液加入至少一种氨基酸，进一步加入白蛋白或非离子表面活性剂中的一种或组合。

公开(公告)号：US08613450B2

公开(公告)日：2013-12-24

申请号：US13517379

申请日：2011-03-07

申请人： Tetsuya Sato ,  Yoichi Ogata

发明人： Tetsuya Sato ,  Yoichi Ogata

IPC分类号： F16J15/34

CPC分类号： F16J15/3464 ,  F16L58/182

摘要： Disclosed is a completely nonmetallic pipe connection mechanism for a seal device. In the pipe connecting mechanism of the present invention, a metallic reinforcing pipe (60) is screwed in a through-bore (53) of a flange (50), and a resin connecting pipe (70) is inserted into a through-bore (67) and an expanding diameter portion (68) of the metallic reinforcing pipe (60). Also, a metallic cap (80) is installed in a head (63) of the metallic reinforcing pipe (60), and a large diameter portion (74) of the resin connecting pipe (70) is sandwiched between the metallic reinforcing pipe (60) and the metallic cap (80). Also, a tapered male screw (96) of a resin connector (90) is screwed in a tapered female screw (76) of the large diameter portion (74) of the resin connecting pipe (70) to connect a tube (98) with the resin connecting pipe (70). The tip portion of the resin connecting pipe (70) is provided with an O-ring (72), which is arranged on an expanding diameter portion (16) of the stationary ring (10) to seal between an outer circumference surface of the resin connecting pipe (70) and an inner circumference surface of the expanding diameter portion (16).

摘要翻译： 公开了一种用于密封装置的完全非金属管连接机构。 在本发明的管连接机构中，将金属加强管（60）拧入法兰（50）的通孔（53）中，将树脂连接管（70）插入通孔（ 67）和金属加强管（60）的扩径部（68）。 此外，在金属加强管（60）的头部（63）上安装有金属盖（80），树脂连接管（70）的大径部（74）夹在金属加强管（60） ）和金属盖（80）。 此外，树脂连接器（90）的锥形外螺纹（96）旋入树脂连接管（70）的大直径部分（74）的锥形阴螺纹（76）中，以将管（98）与 树脂连接管（70）。 树脂连接管（70）的前端设置有O形环（72），其设置在固定环（10）的扩径部（16）上，以密封树脂的外周表面 连接管（70）和扩径部（16）的内周面。

公开(公告)号：US07612127B2

公开(公告)日：2009-11-03

申请号：US10583449

申请日：2004-12-21

申请人： Kazuhiro Oshima ,  Yoichi Ogata

发明人： Kazuhiro Oshima ,  Yoichi Ogata

IPC分类号： C08K3/22 ,  C08G59/40

CPC分类号： C09J133/06 ,  C08F2/44 ,  C08F20/26 ,  C08F230/08 ,  C08K3/22 ,  C08K5/14 ,  C08K7/00 ,  H01L23/293 ,  H01L23/295 ,  H01L2924/0002 ,  H01L2924/00

摘要： It is to provide a curable resin composition which is curable at room temperature, has fluidity, is excellent in workability and provides a cured product having high thermal conductivity and being excellent in flexibility.A curable resin composition comprising a (meth)acrylate monomer, an organic peroxide, a decomposition accelerator for the organic peroxide, and an inorganic filler, wherein the inorganic filler has a particle size distribution such that it has peak diameters at least in the respective regions of from 3 to 10 μm and from 30 to 70 μm, and the mode diameter is from 30 to 70 μm and the median diameter is from 5 to 40 μm.

摘要翻译： 提供一种在室温下可固化，具有流动性，加工性优异的固化性树脂组合物，提供导热性高，柔软性优异的固化物。 一种包含（甲基）丙烯酸酯单体，有机过氧化物，有机过氧化物的分解促进剂和无机填料的可固化树脂组合物，其中所述无机填料具有至少在各个区域中具有峰值直径的粒度分布 为3至10μm和30至70μm，模直径为30至70μm，中值直径为5至40μm。

公开(公告)号：US4816338A

公开(公告)日：1989-03-28

申请号：US48754

申请日：1987-05-12

申请人： Ryuichi Terasaki ,  Shinsei Sato ,  Yoichi Ogata ,  Kazumi Nozawa ,  Yukihiko Nakajima

发明人： Ryuichi Terasaki ,  Shinsei Sato ,  Yoichi Ogata ,  Kazumi Nozawa ,  Yukihiko Nakajima

IPC分类号： C04B35/524 ,  B32B9/04 ,  C01B31/00

CPC分类号： C04B35/524 ,  Y10T428/24942 ,  Y10T428/264 ,  Y10T428/30

摘要： A glassy carbon-coated article contains a graphite substrate and a glassy carbon coating applied on the graphite substrate. The coating has a thickness of 15 to 200 microns. The glassy carbon is obtained by heating a raw material containing a thermal decomposition product of an organic polymer and a heat resistant inorganic substance. The difference of thermal expansion coefficient between the glassy carbon and the graphite substrate is not higher than 1.5.times.10.sup.-6 /.degree.C.

摘要翻译： 玻璃状碳涂层制品包含石墨基底和涂在石墨基片上的玻璃碳涂层。 该涂层的厚度为15-200微米。 通过加热含有有机聚合物和耐热无机物质的热分解产物的原料，得到玻璃状碳。 玻璃碳与石墨基板之间的热膨胀系数之差不高于1.5×10 -6 /℃。

公开(公告)号：US20120267860A1

公开(公告)日：2012-10-25

申请号：US13517379

申请日：2011-03-07

申请人： Tetsuya Sato ,  Yoichi Ogata

发明人： Tetsuya Sato ,  Yoichi Ogata

IPC分类号： F16J15/34 ,  F16L15/00 ,  F16L21/00

CPC分类号： F16J15/3464 ,  F16L58/182

摘要： Disclosed is a completely nonmetallic pipe connection mechanism for a seal device. In the pipe connecting mechanism of the present invention, a metallic reinforcing pipe (60) is screwed in a through-bore (53) of a flange (50), and a resin connecting pipe (70) is inserted into a through-bore (67) and an expanding diameter portion (68) of the metallic reinforcing pipe (60). Also, a metallic cap (80) is installed in a head (63) of the metallic reinforcing pipe (60), and a large diameter portion (74) of the resin connecting pipe (70) is sandwiched between the metallic reinforcing pipe (60) and the metallic cap (80). Also, a tapered male screw (96) of a resin connector (90) is screwed in a tapered female screw (76) of the large diameter portion (74) of the resin connecting pipe (70) to connect a tube (98) with the resin connecting pipe (70). The tip portion of the resin connecting pipe (70) is provided with an O-ring (72), which is arranged on an expanding diameter portion (16) of the stationary ring (10) to seal between an outer circumference surface of the resin connecting pipe (70) and an inner circumference surface of the expanding diameter portion (16).

摘要翻译： 公开了一种用于密封装置的完全非金属管连接机构。 在本发明的管连接机构中，将金属加强管（60）拧入法兰（50）的通孔（53）中，将树脂连接管（70）插入通孔（ 67）和金属加强管（60）的扩径部（68）。 此外，在金属加强管（60）的头部（63）上安装有金属盖（80），树脂连接管（70）的大径部（74）夹在金属加强管（60） ）和金属盖（80）。 此外，树脂连接器（90）的锥形外螺纹（96）旋入树脂连接管（70）的大直径部分（74）的锥形阴螺纹（76）中，以将管（98）与 树脂连接管（70）。 树脂连接管（70）的前端设置有O形环（72），其设置在固定环（10）的扩径部（16）上，以密封树脂的外周表面 连接管（70）和扩径部（16）的内周面。

公开(公告)号：US20070142528A1

公开(公告)日：2007-06-21

申请号：US10583449

申请日：2004-12-21

申请人： Kazuhiro Oshima ,  Yoichi Ogata

发明人： Kazuhiro Oshima ,  Yoichi Ogata

IPC分类号： C08K3/22 ,  C08G59/40

CPC分类号： C09J133/06 ,  C08F2/44 ,  C08F20/26 ,  C08F230/08 ,  C08K3/22 ,  C08K5/14 ,  C08K7/00 ,  H01L23/293 ,  H01L23/295 ,  H01L2924/0002 ,  H01L2924/00

摘要： It is to provide a curable resin composition which is curable at room temperature, has fluidity, is excellent in workability and provides a cured product having high thermal conductivity and being excellent in flexibility. A curable resin composition comprising a (meth)acrylate monomer, an organic peroxide, a decomposition accelerator for the organic peroxide, and an inorganic filler, wherein the inorganic filler has a particle size distribution such that it has peak diameters at least in the respective regions of from 3 to 10 μm and from 30 to 70 μm, and the mode diameter is from 30 to 70 μm and the median diameter is from 5 to 40 μm.

摘要翻译： 提供一种在室温下可固化，具有流动性，加工性优异的固化性树脂组合物，提供导热性高，柔软性优异的固化物。 一种包含（甲基）丙烯酸酯单体，有机过氧化物，有机过氧化物的分解促进剂和无机填料的可固化树脂组合物，其中所述无机填料具有至少在各个区域中具有峰值直径的粒度分布 为3至10μm和30至70μm，模直径为30至70μm，中值直径为5至40μm。

公开(公告)号：US5831025A

公开(公告)日：1998-11-03

申请号：US637662

申请日：1996-04-29

申请人： Yoichi Ogata ,  Toshinobu Nouchi ,  Shinji Nakahira

发明人： Yoichi Ogata ,  Toshinobu Nouchi ,  Shinji Nakahira

IPC分类号： A61K38/46 ,  A61P7/02 ,  C07K1/18 ,  C07K1/22 ,  C07K14/755 ,  C12N9/64 ,  A61K35/16 ,  A61K38/16 ,  C07K17/14 ,  C12Q1/56

CPC分类号： C12N9/6464 ,  C12Y304/21069 ,  Y10S530/83 ,  Y10S530/856

摘要： A human Activated Protein C preparation with a high specific activity of 3500 U/mg or more and substantially free from thrombin or other proteases which can convert Protein C into Activated Protein C is provided. A process for preparing this human Activated Protein C, which involves, contacting a solution of human Activated Protein C, after activation of Protein C with thrombin or other activating protease, with a cation exchanger to allow for adsorption of both thrombin or another activating protease and Activated Protein C to the cation exchanger followed by elution of the human Activated Protein C alone.

摘要翻译： PCT No.PCT / JP94 / 01807 Sec。 371日期：1996年4月29日 102（e）日期1996年4月29日PCT 1994年10月27日PCT公布。 公开号WO95 / 11966 日期1996年5月4日提供具有3500U / mg以上的高比活性和基本上不含可将蛋白C转化成活化蛋白C的凝血酶或其它蛋白酶的人活化蛋白C制剂。 制备这种人活化蛋白C的方法，其涉及在将蛋白C与凝血酶或其它活化蛋白酶一起活化后将人活化蛋白C的溶液与阳离子交换剂接触以允许凝血酶或另一活化蛋白酶的吸附， 将活化的蛋白C转移至阳离子交换剂，然后单独洗脱人活化蛋白C。