-
公开(公告)号:US5112944A
公开(公告)日:1992-05-12
申请号:US536764
申请日:1990-06-12
CPC分类号: C07K5/126 , Y10S930/27
摘要: A cyclic tetrapeptide having the formula (I): ##STR1## wherein n is 4 or 3 and a process for preparing the above cyclic tetrapeptide. The cyclic tetrapeptide of the present invention inhibits transformation of cells caused by oncogenes and possesses activities for recovering to a normal cell and for inhibiting proliferation of carcinoma cells. Therefore, the cyclic tetrapeptide of the present invention is useful for an active ingredient of an antitumor agent.
-
公开(公告)号:US5534654A
公开(公告)日:1996-07-09
申请号:US98272
申请日:1993-08-03
IPC分类号: C07C59/64 , C07C259/06 , C07C271/28 , C07C311/08 , C07C311/19 , C07C311/21 , C07C311/29 , C07D209/18 , A61K31/18 , C07C259/04 , C07C311/30
CPC分类号: C07C311/19 , C07C259/06 , C07C271/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C59/64 , C07D209/18
摘要: A novel hydroxamic acid compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof having cell growth inhibition, vascularization inhibition activities and the like.The compounds of the present invention possess inhibitory activities against the growth of vascular endothelial cells and the expression of lymphocyte adhesive factors and the detransforming activity of cells transformed by ras gene, and inhibit the cell growth and are effective on inflammation and tumor.
摘要翻译: PCT No.PCT / JP92 / 01593 Sec。 371日期1993年8月3日 102(e)日期1993年8月3日PCT提交1992年12月7日PCT公布。 公开号WO91 / 12075 日期:1992年6月24日。具有细胞生长抑制,血管形成抑制活性等的新颖的下式的异羟肟酸化合物:其具有下式:(I)或其药学上可接受的盐。 本发明化合物对血管内皮细胞的生长和淋巴细胞粘附因子的表达以及由ras基因转化的细胞的转化活性具有抑制作用,抑制细胞生长,对炎症和肿瘤有效。
-