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公开(公告)号：US4169764A
公开(公告)日：1979-10-02
申请号：US851480
申请日：1977-11-14
CPC分类号： C12N9/6462 , C12Y304/21073 , Y10S435/815
摘要： Method for the isolation of urokinase from human urine in which the urokinase is adsorbed and thereafter eluted with aqueous cation surfactant mixture. Novel carboxyalkyl cellulose is utilized as a preferred adsorbent.
摘要翻译： 从其中尿激酶被吸附的尿液中分离尿激酶的方法，然后用水性阳离子表面活性剂混合物洗脱。 新的羧基烷基纤维素被用作优选的吸附剂。
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公开(公告)号：US3950223A
公开(公告)日：1976-04-13
申请号：US422789
申请日：1973-12-07
申请人： Yasumi Yugari , Kenji Takezawa
发明人： Yasumi Yugari , Kenji Takezawa
CPC分类号： C12N9/6462 , C12N9/96 , C12Y304/21073 , A61K38/00
摘要： The activity of urokinase in aqueous solution is stabilized and enhanced by addition of water soluble amines selected from the group consisting of amino sugars, amino acids and cationic surfactants.
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公开(公告)号：US4397840A
公开(公告)日：1983-08-09
申请号：US354302
申请日：1982-03-03
申请人： Kenji Takezawa , Hajima Hiratani
发明人： Kenji Takezawa , Hajima Hiratani
IPC分类号： A61K38/22 , A61K38/00 , C07K14/505 , A61K35/22
CPC分类号： C07K14/505 , A61K38/00 , Y10S530/834
摘要： The invention provides a novel erythropoietin product prepared from the urine of healthy human but exhibiting no inhibitory effect against erythropoiesis as is the most disadvantageous problem in the product prepared from the urine of healthy human. The method for the preparation of such a product comprises adsorbing the crude erythropoietin product obtained from the urine of healthy human on to a weakly basic anion exchanger from a neutral or weakly acidic aqueous solution containing 0.1 to 0.2 mole per liter of an inorganic neutral salt such as sodium chloride and then eluting the thus adsorbed ingredients with an aqueous eluant solution containing from 0.5 to 0.7 mole per liter of an inorganic neutral salt.
摘要翻译： 本发明提供了一种由健康人的尿液制备的新型促红细胞生成素产品，但是对于红细胞生成没有抑制作用，因为从健康人的尿制备的产品中最不利的问题。 制备这种产品的方法包括将从健康人的尿获得的粗制促红细胞生成素产物从含有0.1至0.2摩尔/升无机中性盐的中性或弱酸性水溶液吸附在弱碱性阴离子交换剂上， 然后用含有0.5至0.7摩尔/升无机中性盐的含水洗脱液洗脱由此吸附的成分。
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公开(公告)号：US4303650A
公开(公告)日：1981-12-01
申请号：US193159
申请日：1980-10-02
申请人： Kenji Takezawa , Hajime Hiratani
发明人： Kenji Takezawa , Hajime Hiratani
IPC分类号： B01D15/00 , A61K35/22 , A61K38/00 , B01J20/26 , C07K14/435 , C07K14/505 , A61K37/00 , C07G7/00
CPC分类号： C07K14/505 , A61K38/00 , Y10S530/834
摘要： The invention provides a novel process for the production of erythropoietin, which is a promising medicine for curing anemia, from human urine containing the same. The inventive method comprises adjusting the pH value of the urine in the range from 6 to 8, if the pH value of the urine is out of this range, and contacting the thus pH-controlled urine with a specific adsorbent so as that the erythropoietin is selectively adsorbed on the adsorbent. The adsorbed erythropoietin is then eluted out by use of an eluant solution to give the product in a partially purified form.
摘要翻译： 本发明提供了一种用于生产促红细胞生成素的新方法，该促红细胞生成素是用于治疗贫血的有希望的药物。 本发明的方法包括如果尿液的pH值超出该范围，则将尿液的pH值调节在6至8的范围内，并使由此控制的pH与特定吸附剂接触，使得红细胞生成素为 选择性吸附在吸附剂上。 吸附的促红细胞生成素然后通过使用洗脱液溶出，以产生部分纯化的形式。
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公开(公告)号：US08343060B2
公开(公告)日：2013-01-01
申请号：US12071873
申请日：2008-02-27
IPC分类号： A61B5/02
CPC分类号： A61B8/0858 , A61B5/02007 , A61B5/0205 , A61B5/02225 , A61B5/0225 , A61B5/1075 , A61B8/5238 , A61B8/543
摘要： In a process of varying pressure of a pressure container (24) accommodating a forearm (22) of a subject (20) in a pressure range including negative pressure, a diameter (cross-sectional shape value) (D) of an artery 44 in the forearm (22) accommodated in the pressure container (24) is measured non-invasively by a vascular diameter calculating unit (76). In addition, a display controller (display controlling means) (80) operates to display on a displaying device (16) a variation of an internal pressure (Pc) in the pressure container (24) and a variation of the diameter (D) of the artery (44) varying depending thereon. Based on the diameter (D) of the artery (44) obtained in the high pressure region, the variation of the internal pressure Pc in the pressure container 24 and the variation of the diameter (D) of the artery 44 varying depending thereon i.e. mechanical properties of the artery (44) are displayed on the displaying device (16). The artery (44) can be evaluated accurately based on the mechanical properties.
摘要翻译： 在包含受试者（20）的前臂（22）的压力容器（24）的压力变化的压力范围内，包括负压，动脉44的直径（横截面形状值）（D） 容纳在压力容器（24）中的前臂（22）由血管直径计算单元（76）非侵入性地测量。 此外，显示控制器（显示控制装置）（80）操作以在显示装置（16）上显示压力容器（24）中的内部压力（Pc）的变化和直径（D）的变化 动脉（44）随之而变化。 基于在高压区域中获得的动脉（44）的直径（D），压力容器24中的内部压力Pc的变化和动脉44的直径（D）随其变化而变化，即机械 在显示装置（16）上显示动脉（44）的特性。 动脉（44）可以根据机械性能进行准确评估。
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公开(公告)号：US20080214961A1
公开(公告)日：2008-09-04
申请号：US12071873
申请日：2008-02-27
IPC分类号： A61B5/107
CPC分类号： A61B8/0858 , A61B5/02007 , A61B5/0205 , A61B5/02225 , A61B5/0225 , A61B5/1075 , A61B8/5238 , A61B8/543
摘要： In a process of varying pressure of a pressure container (24) accommodating a forearm (22) of a subject (20) in a pressure range including negative pressure, a diameter (cross-sectional shape value) (D) of an artery 44 in the forearm (22) accommodated in the pressure container (24) is measured non-invasively by a vascular diameter calculating unit (76). In addition, a display controller (display controlling means) (80) operates to display on a displaying device (16) a variation of an internal pressure (Pc) in the pressure container (24) and a variation of the diameter (D) of the artery (44) varying depending thereon. Based on the diameter (D) of the artery (44) obtained in the high pressure region, the variation of the internal pressure Pc in the pressure container 24 and the variation of the diameter (D) of the artery 44 varying depending thereon i.e. mechanical properties of the artery (44) are displayed on the displaying device (16). The artery (44) can be evaluated accurately based on the mechanical properties.
摘要翻译： 在包含受试者（20）的前臂（22）的压力容器（24）的压力变化的压力范围内，包括负压，动脉44的直径（横截面形状值）（D） 容纳在压力容器（24）中的前臂（22）由血管直径计算单元（76）非侵入性地测量。 此外，显示控制器（显示控制装置）（80）操作以在显示装置（16）上显示压力容器（24）中的内部压力（Pc）的变化和直径（D）的变化 动脉（44）随之而变化。 基于在高压区域中获得的动脉（44）的直径（D），压力容器24中的内部压力Pc的变化和动脉44的直径（D）随其变化而变化，即机械 在显示装置（16）上显示动脉（44）的特性。 动脉（44）可以根据机械性能进行准确评估。
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