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公开(公告)号：US4303650A
公开(公告)日：1981-12-01
申请号：US193159
申请日：1980-10-02
申请人： Kenji Takezawa , Hajime Hiratani
发明人： Kenji Takezawa , Hajime Hiratani
IPC分类号： B01D15/00 , A61K35/22 , A61K38/00 , B01J20/26 , C07K14/435 , C07K14/505 , A61K37/00 , C07G7/00
CPC分类号： C07K14/505 , A61K38/00 , Y10S530/834
摘要： The invention provides a novel process for the production of erythropoietin, which is a promising medicine for curing anemia, from human urine containing the same. The inventive method comprises adjusting the pH value of the urine in the range from 6 to 8, if the pH value of the urine is out of this range, and contacting the thus pH-controlled urine with a specific adsorbent so as that the erythropoietin is selectively adsorbed on the adsorbent. The adsorbed erythropoietin is then eluted out by use of an eluant solution to give the product in a partially purified form.
摘要翻译： 本发明提供了一种用于生产促红细胞生成素的新方法，该促红细胞生成素是用于治疗贫血的有希望的药物。 本发明的方法包括如果尿液的pH值超出该范围，则将尿液的pH值调节在6至8的范围内，并使由此控制的pH与特定吸附剂接触，使得红细胞生成素为 选择性吸附在吸附剂上。 吸附的促红细胞生成素然后通过使用洗脱液溶出，以产生部分纯化的形式。
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2.发明授权
公开(公告)号：US5281577A
公开(公告)日：1994-01-25
申请号：US962022
申请日：1992-10-15
申请人： Junichi Koga , Yasuhiro Ohashi , Hajime Hiratani
发明人： Junichi Koga , Yasuhiro Ohashi , Hajime Hiratani
IPC分类号： A61K38/00 , C07K14/375 , A61K37/02 , A61K35/84
CPC分类号： C07K14/375 , A61K38/00
摘要： An inhibitor of the proliferation of herpesviruses and of the recurrence of affections caused by their latent infection, which is an active material obtained by fractional purification of the aqueous extract from cultured Lentinus edodes mycelia.
摘要翻译： 疱疹病毒增生的抑制剂及其潜伏感染引起的感染复发，其是通过从培养的香菇菌丝体中分级纯化水提取物获得的活性物质。
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3.发明授权
公开(公告)号：US4479937A
公开(公告)日：1984-10-30
申请号：US524549
申请日：1983-08-19
申请人： Hiroshi Sato , Koji Sasaki , Kaname Takagi , Hajime Hiratani , Yoshikazu Yuki
发明人： Hiroshi Sato , Koji Sasaki , Kaname Takagi , Hajime Hiratani , Yoshikazu Yuki
CPC分类号： C07K14/8139
摘要： An anti-inflammatory agent comprising as an active component an inhibitor specifically inhibiting a thiol protease, which is obtained from human urine by extraction and purification. This agent has an action of inhibiting a disease caused by a thiol protease. This anti-inflammatory agent is prepared by a process in which a thiol protease inhibitor is extracted and purified from human urine by adopting in combination at least two treatments selected from a treatment with a molecular filter, a treatment with an ion exchanger, a treatment with an adsorber and an affinity chromatographic treatment.
摘要翻译： 一种抗炎剂，其包含通过提取和纯化从人尿获得的特异性抑制硫醇蛋白酶的抑制剂作为活性成分。 该药剂具有抑制由硫醇蛋白酶引起的疾病的作用。 该抗炎剂通过以下方法制备，其中通过组合使用选自以下的至少两种处理组合提取和纯化巯基蛋白酶抑制剂：选自用分子过滤器处理，用离子交换剂处理，用离子交换剂处理， 吸附剂和亲和色谱处理。
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4.发明授权
公开(公告)号：US4468344A
公开(公告)日：1984-08-28
申请号：US461383
申请日：1983-01-27
CPC分类号： C07K14/485 , Y10S530/834
摘要： Gastric acid secretion inhibiting substance obtainable from mammalian urine by conventional method is fractionated into the first and second components by gel filtration, adsorption and desorption on ion exchanger or electrophoresis detecting each component by biological test methods. The activities of the two components differ from each other in the biological tests.The first component is a glucoprotein-like substance of M.W. 100,000 and the second component is a peptide-like substance of M.W. about 6,000.
摘要翻译： 通过常规方法从哺乳动物尿获得的胃酸分泌抑制物质通过凝胶过滤，离子交换剂上的吸附和解吸或通过生物试验方法电泳检测各成分而分成第一和第二成分。 这两个组成部分的活动在生物学测试中彼此不同。 第一组分是M.W. 100,000的糖蛋白样物质，第二组分是M.W.约6,000的肽样物质。
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公开(公告)号：US5283239A
公开(公告)日：1994-02-01
申请号：US823061
申请日：1992-01-14
申请人： Junichi Koga , Yasuhiro Ohashi , Hajime Hiratani
发明人： Junichi Koga , Yasuhiro Ohashi , Hajime Hiratani
CPC分类号： A61K36/07 , Y10S514/934
摘要： LEM which is an aqueous extract of a mycelial culture of Lentinus Edodes and has a sugar composition composed of arabinose, xylose, glucose, mannose, galasctose, fucose and rhamnose, as well as a fraction of LEM which corresponds to molecular weights of 10,000 to 1,000,000 daltons and has a sugar composition composed of arabinose, xylose, glucose, mannose and galactose are provided as agents for inhibiting the adsorption of herpesviruses such as herpes simplex to the cells.
摘要翻译： LEM是Lentinus Edodes的菌丝体培养物的水提取物，并且具有由阿拉伯糖，木糖，葡萄糖，甘露糖，半乳糖，岩藻糖和鼠李糖组成的糖组合物，以及对应于10,000至1,000,000的分子量的一部分LEM 道尔顿，并具有由阿拉伯糖，木糖，葡萄糖，甘露糖和半乳糖组成的糖组合物作为用于抑制疱疹病毒如单纯疱疹的细胞吸附的试剂。
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6.发明授权Process for removal of viruses from solutions of physiologically active substances 失效从生理活性物质的溶液中除去病毒的方法
公开(公告)号：US5173415A
公开(公告)日：1992-12-22
申请号：US640569
申请日：1991-01-14
CPC分类号： B01D67/0088 , B01D61/147 , C07K1/34 , C12N9/00
摘要： A membrane filter of 0.025 to 0.05 .mu. in pore size is treated by passing the solution of a water-soluble high molecular substance such as albumin, dextran, polyvinylpyrrolidone, polysorbate 80, gelatin or the like through the membrane filter. Employing the filter thus treated, the solution of a physiologically active substance of human origin such as human growth hormone, kallikrein, trypsin inhibitor, epidermal growth factor, leucocyte interferon etc. is filtered at high recovery rate of the active substance avoiding the adsorption of the active substance onto the filter. By the filtration, harmful viruses such as Creutzfeldt-Jacob disease pathogen which may exist in the physiologically active substance can be removed.
摘要翻译： 通过膜过滤器使诸如白蛋白，葡聚糖，聚乙烯吡咯烷酮，聚山梨醇酯80，明胶等的水溶性高分子物质的溶液进行处理，孔径为0.025〜0.05μm的膜过滤器。 使用如此处理的过滤器，以高回收率的活性物质过滤人类生理活性物质如人生长激素，激肽释放酶，胰蛋白酶抑制剂，表皮生长因子，白细胞干扰素等的溶液，避免吸附 活性物质过滤器。 通过过滤，可以除去可能存在于生理活性物质中的有害病毒如Creutzfeldt-Jacob病病原体。
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7.发明授权Process for preparing a heat-stable aqueous solution of human urine kallikrein and product prepared 失效制备人尿激肽释放酶热稳定水溶液的方法和制备的产品
公开(公告)号：US4500514A
公开(公告)日：1985-02-19
申请号：US557107
申请日：1983-12-01
IPC分类号： C12N9/96 , A61K38/48 , A61L2/00 , A61K37/553
CPC分类号： A61L2/0023 , A61K38/4853
摘要： Human urine kallikrein dissolved in water is made heat-stable by the addition of a citric acid salt such as sodium citrate, so that an aqueous solution containing the kallikrein and the citric acid salt can be sterilized at 60.degree. to 70.degree. C.
摘要翻译： 溶解在水中的人尿激肽释放酶通过加入柠檬酸钠等柠檬酸盐而使其稳定，使得含有激肽释放酶和柠檬酸盐的水溶液可以在60℃至70℃下灭菌。
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公开(公告)号：US5750650A
公开(公告)日：1998-05-12
申请号：US67180
申请日：1993-05-24
摘要： A novel peptide having molecular weight of 31,000 (SDS-PAGE) is obtained from aqueous extract of Natto or the culture of Bacillus natto by purification procedures including alcohol fractionation and/or salting out and hydrophobic chromatography, and the physicochemical properties, including the amino acid sequence, of the peptide are determined. The peptide is active in fibrinolysis, exhibits strong thrombolytic activity by oral administration and is useful as an oral thrombolytic agent.
摘要翻译： 通过包括醇分馏和/或盐析和疏水色谱法的纯化方法从Natto的水提取物或纳豆芽孢杆菌的培养物获得分子量为31,000的新型肽（SDS-PAGE），并且包括氨基酸的物理化学性质 确定肽的序列。 该肽在纤维蛋白溶解中有活性，通过口服给药具有强烈的溶栓活性，可用作口服溶栓剂。
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公开(公告)号：US5296223A
公开(公告)日：1994-03-22
申请号：US960259
申请日：1992-10-13
申请人： Koichiro Nakanishi , Hajime Hiratani , Kazuo Kato
发明人： Koichiro Nakanishi , Hajime Hiratani , Kazuo Kato
IPC分类号： A61K38/46 , A61K9/48 , A61K38/48 , A61P7/02 , A61K37/547
CPC分类号： A61K38/482
摘要： There are provided thrombolytic agents suited for oral administration. The agent comprises a proteolytic enzyme of subtilisin family, such as subtilisin BPN', subtilisin Carsberg, subtilisin amylosacchariticus, etc., produced by microorganisms belonging to genus Bacillus, such as Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens, etc. and, even when administered orally, exhibits thrombolytic activity.
摘要翻译： 提供适合口服给药的溶栓剂。 该试剂包括枯草杆菌蛋白酶家族的蛋白水解酶，如枯草杆菌蛋白酶BPN'，枯草杆菌蛋白酶Carsberg，枯草杆菌蛋白酶淀粉酵母等，由属于芽孢杆菌属的微生物如枯草芽孢杆菌，地衣芽孢杆菌，解淀粉芽孢杆菌等产生，并且即使 口服给药，具有溶栓活性。
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10.发明授权Method of assaying or analyzing subtypes of human leukocyte interferons or their antibodies, and antibodies to be used therefor 失效检测或分析人类白细胞介素或其抗体的亚型的方法及其使用的抗体
公开(公告)号：US5240864A
公开(公告)日：1993-08-31
申请号：US621825
申请日：1990-12-04
申请人： Junichi Koga , Hiroyuki Shirono , Akio Matsuo , Hajime Hiratani
发明人： Junichi Koga , Hiroyuki Shirono , Akio Matsuo , Hajime Hiratani
IPC分类号： G01N33/53 , C07K14/56 , C07K16/24 , G01N30/88 , G01N33/531
CPC分类号： C07K14/56 , C07K16/249
摘要： Antiserum which can recognize all subtypes of human leukocyte interferon is prepared from the blood of an animal immunized with partially purified human leukocyte interferon obtained from a culture of human leukocyte stimulated with Sendai virus.The antiserum is added to a column whereon concentrated culture broth of human leukocyte has been immobilized to adsorb impurities, the effluent is added to a column whereon partially purified human leukocyte interferon has been immobilized to adsorb anti-human leukocyte interferon antibody and then the antibody is eluted from the column.The antibody thus obtained recognizes all subtypes of human leukocyte interferon and can be separated by a chromatography to each monoclonal antibody which recognizes a single subtype.Employing these antibodies, the subtypes of human leukocyte interferon or their antibodies in a sample can be analized or assayed.
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