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公开(公告)号：USH1148H
公开(公告)日：1993-03-02
申请号：US815870
申请日：1992-01-03
CPC分类号： C12N9/6464 , C07K16/40 , C12Y304/21069
摘要： A method of separating activated human protein C, which comprises bringing a mixture containing activated human protein C having a gamma-carboxyglutamic acid (Gla) domain in the presence of a calcium ion into contact with a fixed antibody comprising an insoluble carrier and fixed thereto an antibody to a complex of human protein C and a calcium ion bound to the Gla domain whereby the activated human protein C is captured by the fixed antibody in the form in which the calcium ion is bound to the Gla domain. A method is also provided for separating activated human protein C from a mixture containing human protein C and activated human protein C, which comprises bringing a first mixture containing human protein C and activated human protein C having a Gla domain into contact with a first fixed antibody comprising an insoluble carrier and fixed thereto a first antibody to human protein C but not to activated human protein C to form a second mixture substantially free from human protein C while the human protein C is captured by the first fixed antibody, and bringing the second mixture in the presence of a calcium ion into contact with a second fixed antibody comprising an insoluble carrier and fixed thereto a second antibody to a complex of human protein C and a calcium ion bound at the Gla domain, whereby the activated human protein C is captured by the second fixed antibody in the form in which the calcium ion is bound to the Gla domain.
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公开(公告)号：US4902614A
公开(公告)日：1990-02-20
申请号：US804255
申请日：1985-12-03
申请人： Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa , Yoichi Sakata , Jun Mimuro , Nobuo Aoki
发明人： Kenji Wakabayashi , Yoshihiko Sumi , Yataro Ichikawa , Yoichi Sakata , Jun Mimuro , Nobuo Aoki
CPC分类号： C07K16/40 , G01N33/86 , G01N2333/96461 , Y10S435/815
摘要： A monoclonal antibody which is specific to human protein C which has calcium bound at the gammacarboxyglutamic acid(Gla) domain and does not recognize human protein C which is not bound to calcium at the Gla domain. The monoclonal antibody is used in an immunoassay method for determining human protein C having a Gla domain and in a method for recovering human protein C having a Gal domain.
摘要翻译： 对人蛋白C特异性的单克隆抗体，其具有在γ-氨基谷氨酸（Gla）结构域处结合钙并且不识别在Gla结构域不与钙结合的人蛋白质C。 单克隆抗体用于测定具有Gla结构域的人蛋白C的免疫测定方法和用于回收具有Gal结构域的人蛋白C的方法。
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3.发明授权Immunological determination of free human protein S and C4bp-protein S complex 失效游离人蛋白S和C4bp蛋白S复合物的免疫测定
公开(公告)号：US5187067A
公开(公告)日：1993-02-16
申请号：US670383
申请日：1991-03-14
CPC分类号： C07K16/18 , C07K16/36 , Y10S436/821 , Y10S436/824
摘要： A method of immunologically determining free human protein S in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, the primary and secondary antibodies having the property of binding to different epitopes of free human protein S, and one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to a complex of the human protein S and human complement cofactor C4b-binding protein (C4bp) but specifically binding to the free human protein S. Also provided is a method of immunologically determining a complex of human protein S and human complement cofactor C4b-binding protein (C4bp) in an assay sample, which comprises contacting a primary antibody fixed to an insoluble solid carrier and a labelled secondary antibody with the assay sample, one of the primary and secondary antibodies being a monoclonal antibody having the property of not binding to free human protein S and human complement cofactor C4b-binding protein (C4bp) but binding specifically to the complex, and the other being an antibody having the property of binding to the human complement cofactor C4b-binding protein (4Cbp).
摘要翻译： 一种在测定样品中免疫测定游离人蛋白S的方法，其包括将固定在不溶性固体载体上的第一抗体与标记的第二抗体与测定样品接触，所述第一抗体和第二抗体具有结合不同表位的性质 游离人蛋白S，其中一种和第二种抗体是具有不与人类蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物结合但与结合游离人蛋白质的特异性的单克隆抗体 还提供了在测定样品中免疫测定人蛋白S和人补体辅因子C4b结合蛋白（C4bp）的复合物的方法，其包括将固定于不溶性固体载体的第一抗体和标记的第二抗体与 测定样品，其中一种和第二种抗体是具有不结合特性的单克隆抗体 g释放人蛋白S和人补体辅因子C4b结合蛋白（C4bp），但与复合物特异性结合，另一种是具有与人补体辅因子C4b结合蛋白（4Cbp）结合的性质的抗体。
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公开(公告)号：US4960611A
公开(公告)日：1990-10-02
申请号：US250643
申请日：1988-09-29
摘要： A method of remedying a coating characterized by irradiating a minute defect in the coating due to the adhesion of a dust particle, oil droplet or the like with a laser beam having a cross section generally in conformity with the defect to sublime the dust particle, oil droplet or the like and the coating at the defective portion and form a minute cavity in the coating, filling a repair coating composition into the cavity and curing the composition.
摘要翻译： 一种补救涂层的方法，其特征在于，由于灰尘颗粒，油滴等与通常与缺陷相符的横截面的激光束的粘附而在涂层中照射微小缺陷，以使灰尘颗粒，油 液滴等以及在缺陷部分处的涂层，并在涂层中形成微小空腔，将修复涂料组合物填充到空腔中并固化组合物。
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5.发明申请STABILIZED PHARMACEUTICAL COMPOSITION CONTAINING DONEPEZIL, PROCESS OF PRODUCING SAME AND METHOD FOR STABILIZATION 审中-公开含有二苯乙烯的稳定化学药物组合物，其生产方法和稳定化方法公开(公告)号：US20100016362A1
公开(公告)日：2010-01-21
申请号：US12523679
申请日：2008-01-18
IPC分类号： A61K31/4353
摘要： An object of the present invention is to provide a novel pharmaceutical composition containing donepezil, which is already used as a remedy for the treatment of dementia (cognitive impairment), in order to increase options for administration methods and improve patient compliance. The present invention provides a pharmaceutical composition containing donepezil or a pharmaceutically acceptable salt thereof and a naturally-occurring polymer, the pharmaceutical composition further containing at least one of edetate, sulfite, dibutylhydroxytoluene and butylhydroxyanisole.
摘要翻译： 本发明的目的是提供一种含有多奈哌齐的新型药物组合物，其已被用作治疗痴呆症（认知障碍）的补救剂，以增加给药方法的选择并提高患者依从性。 本发明提供含有多奈哌齐或其药学上可接受的盐和天然存在的聚合物的药物组合物，所述药物组合物还含有依地酸，亚硫酸盐，二丁基羟基甲苯和丁基羟基苯甲醚中的至少一种。
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