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    Method of separating activated human protein C
    2.
    依法登记的发明
    Method of separating activated human protein C 失效

    公开(公告)号：USH1148H

    公开(公告)日：1993-03-02

    申请号：US815870

    申请日：1992-01-03

    申请人： Kenji Wakabayashi ,  Yoshihiko Sumi ,  Yataro Ichikawa ,  Yoichi Sakata ,  Nobuo Aoki

    发明人： Kenji Wakabayashi ,  Yoshihiko Sumi ,  Yataro Ichikawa ,  Yoichi Sakata ,  Nobuo Aoki

    IPC分类号： C07K16/40 ,  C12N9/64

    CPC分类号： C12N9/6464 ,  C07K16/40 ,  C12Y304/21069

    摘要： A method of separating activated human protein C, which comprises bringing a mixture containing activated human protein C having a gamma-carboxyglutamic acid (Gla) domain in the presence of a calcium ion into contact with a fixed antibody comprising an insoluble carrier and fixed thereto an antibody to a complex of human protein C and a calcium ion bound to the Gla domain whereby the activated human protein C is captured by the fixed antibody in the form in which the calcium ion is bound to the Gla domain. A method is also provided for separating activated human protein C from a mixture containing human protein C and activated human protein C, which comprises bringing a first mixture containing human protein C and activated human protein C having a Gla domain into contact with a first fixed antibody comprising an insoluble carrier and fixed thereto a first antibody to human protein C but not to activated human protein C to form a second mixture substantially free from human protein C while the human protein C is captured by the first fixed antibody, and bringing the second mixture in the presence of a calcium ion into contact with a second fixed antibody comprising an insoluble carrier and fixed thereto a second antibody to a complex of human protein C and a calcium ion bound at the Gla domain, whereby the activated human protein C is captured by the second fixed antibody in the form in which the calcium ion is bound to the Gla domain.

    cDNA and genomic DNA encoding the amino acid sequence of human .alpha..sub.2 -plasmin inhibition
    3.
    发明授权
    cDNA and genomic DNA encoding the amino acid sequence of human .alpha..sub.2 -plasmin inhibition 失效
    编码人α2-纤溶酶抑制的氨基酸序列的cDNA和基因组DNA

    公开(公告)号：US5221738A

    公开(公告)日：1993-06-22

    申请号：US803896

    申请日：1991-12-09

    申请人： Yoshihiko Sumi ,  Yataro Ichikawa ,  Masami Murakami ,  Nobuo Aoki

    发明人： Yoshihiko Sumi ,  Yataro Ichikawa ,  Masami Murakami ,  Nobuo Aoki

    IPC分类号： C07K14/81 ,  C12N15/55

    CPC分类号： C07K14/8121

    摘要： cDNA encoding a human .alpha..sub.2 -plasmin inhibitor precursor protein represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; an amino acid sequence of a human .alpha..sub.2 -plasmin inhibitor precursor represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; and genomic DNA encoding a human .alpha..sub.2 -plasmin inhibitor protein which is composed of exons II, III, IV, V, VI, VII, VIII, IX and X in FIG. 4 of the accompanying drawings, said exons being bonded to one another via introns.

    摘要翻译： 编码人α2-纤溶酶原抑制物前体蛋白的cDNA，由图3中的第39位Met至第452位Lys的氨基酸序列表示。 附图1; 由图3中的第39位Met至第452位Lys的氨基酸序列表示的人α2-纤溶酶抑制剂前体的氨基酸序列。 附图1; 以及编码图2中由外显子II，III，IV，V，VI，VII，VIII，IX和X组成的人α2-纤溶酶抑制蛋白的基因组DNA。 附图4中，所述外显子通过内含子彼此结合。

    Monoclonal antibody specific to human .alpha..sub.2 -plasmin inhibitor
    6.
    发明授权
    Monoclonal antibody specific to human .alpha..sub.2 -plasmin inhibitor 失效
    对人α2-纤溶酶抑制剂特异性的单克隆抗体

    公开(公告)号：US5534255A

    公开(公告)日：1996-07-09

    申请号：US716694

    申请日：1991-06-17

    申请人： Yoshihiko Sumi ,  Yukiya Koike ,  Yataro Ichikawa ,  Nobuhiko Yoshida ,  Nobuo Aoki

    发明人： Yoshihiko Sumi ,  Yukiya Koike ,  Yataro Ichikawa ,  Nobuhiko Yoshida ,  Nobuo Aoki

    IPC分类号： A61K38/00 ,  C07K14/81 ,  C07K16/38 ,  C12P21/08 ,  A61K39/00 ,  C07K16/00

    CPC分类号： C07K16/38 ,  C07K14/8121 ,  A61K38/00 ,  Y10S530/864 ,  Y10S530/866

    摘要： This invention provides a monoclonal antibody or its fragment specific to a human .alpha..sub.2 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human .alpha..sub.2 -plasmin inhibitor which inhibits the fibrinolytic activity of plasmin, and of suppressing said fibrinolytic activity inhibiting function of said .alpha..sub.2 -plasmin inhibitor, and also a hybridoma capable of producing the monoclonal antibody. Said monoclonal antibody or its fragment is useful for the immunological determination of a human .alpha..sub.2 -plasmin inhibitor, the separation or recovery of a human .alpha..sub.2 -plasmin inhibitor from a liquid containing the human .alpha..sub.2 -plasmin inhibitor, and the treatment of a thrombotic disease.

    摘要翻译： 本发明提供了对人α2-纤溶酶抑制剂特异性的单克隆抗体或其片段，所述抗体具有特异性阻断人α2-纤溶酶抑制剂的位点的功能，其抑制纤溶酶的纤维蛋白溶解活性，并抑制所述纤维蛋白溶解 所述α2-纤溶酶抑制剂的活性抑制功能，以及能够产生单克隆抗体的杂交瘤。 所述单克隆抗体或其片段可用于免疫测定人α2-纤溶酶抑制剂，从含有人α2-纤溶酶抑制剂的液体中分离或回收人α2-纤溶酶抑制剂，以及治疗 血栓性疾病

    Fuel supply pump and tappet structure body
    7.
    发明授权
    Fuel supply pump and tappet structure body 有权
    燃油泵和挺杆结构体

    公开(公告)号：US07513756B2

    公开(公告)日：2009-04-07

    申请号：US11018220

    申请日：2004-12-21

    申请人： Nobuo Aoki ,  Kazuya Kubota ,  Takeshi Terada ,  Noriyuki Kobayashi

    发明人： Nobuo Aoki ,  Kazuya Kubota ,  Takeshi Terada ,  Noriyuki Kobayashi

    IPC分类号： F04B19/00 ,  F01B31/10

    CPC分类号： F02M63/0225 ,  F02M47/027 ,  F02M57/025 ,  F02M59/102 ,  F02M59/105

    摘要： A fuel supply pump with a large fuel discharge amount and a tappet structure body, which are suitably used for an accumulated pressure-type fuel injection device that mechanically amplifies pressure, is provided. A fuel supply pump has a tappet structural body and a spring sheet, wherein a penetration portion for allowing passage of a lubricant or a fuel for lubrication therethrough by coordinating the tappet structure and the spring sheet is provided between a spring-holding chamber for holding a spring to be used for pulling up a plunger and a cam chamber for housing a cam to be used for moving the plunger up and down.

    摘要翻译： 提供了具有大的燃料排出量的燃料供给泵和挺杆结构体，其适用于机械地放大压力的积压式燃料喷射装置。 燃料供给泵具有挺杆结构体和弹簧片，其特征在于，在所述挺杆结构体和弹簧片的弹簧保持室之间设置用于通过配合所述挺杆结构和所述弹簧片而使润滑剂或用于润滑的燃料通过的贯通部 用于拉起柱塞的弹簧和用于容纳用于上下移动柱塞的凸轮的凸轮室。

    Fuel supply pump and tappet structure body
    8.
    发明申请
    Fuel supply pump and tappet structure body 有权
    燃油泵和挺杆结构体

    公开(公告)号：US20050106049A1

    公开(公告)日：2005-05-19

    申请号：US11018220

    申请日：2004-12-21

    申请人： Nobuo Aoki ,  Kazuya Kubota ,  Takeshi Terada ,  Noriyuki Kobayashi

    发明人： Nobuo Aoki ,  Kazuya Kubota ,  Takeshi Terada ,  Noriyuki Kobayashi

    IPC分类号： F02M47/02 ,  F02M57/02 ,  F02M59/10 ,  F02M59/36 ,  F02M59/46 ,  F02M63/02 ,  F04B1/00

    CPC分类号： F02M63/0225 ,  F02M47/027 ,  F02M57/025 ,  F02M59/102 ,  F02M59/105

    摘要： A fuel supply pump with a large fuel discharge amount and a tappet structure body, which are suitably used for an accumulated pressure-type fuel injection device that mechanically amplifies pressure, is provided. A fuel supply pump has a tappet structural body and a spring sheet, wherein a penetration portion for allowing passage of a lubricant or a fuel for lubrication therethrough by coordinating the tappet structure and the spring sheet is provided between a spring-holding chamber for holding a spring to be used for pulling up a plunger and a cam chamber for housing a cam to be used for moving the plunger up and down.

    摘要翻译： 提供了具有大的燃料排出量的燃料供给泵和挺杆结构体，其适用于机械地放大压力的积压式燃料喷射装置。 燃料供给泵具有挺杆结构体和弹簧片，其特征在于，在所述挺杆结构体和弹簧片的弹簧保持室之间设置用于通过配合所述挺杆结构和所述弹簧片而使润滑剂或用于润滑的燃料通过的贯通部 用于拉起柱塞的弹簧和用于容纳用于上下移动柱塞的凸轮的凸轮室。

    Power supplying unit for submerged motor
    10.
    发明授权
    Power supplying unit for submerged motor 失效
    潜水电机供电装置

    公开(公告)号：US5343103A

    公开(公告)日：1994-08-30

    申请号：US651413

    申请日：1990-12-12

    申请人： Nobuo Aoki ,  Ikuo Aizawa ,  Keisuke Yokoi ,  Hideo Negishi

    发明人： Nobuo Aoki ,  Ikuo Aizawa ,  Keisuke Yokoi ,  Hideo Negishi

    IPC分类号： H01B17/26 ,  H01B17/30 ,  H02G3/22 ,  H02K5/10 ,  H02G15/02

    CPC分类号： H01B17/30 ,  H01B17/26

    摘要： Power supplying unit to be used for supplying power to such a load as the motor for driving a submerged pump that scoops liquid out of a tank storing low temperature liquid like LNG and so forth. The power supplying unit has a ceramic sleeve fixed to the flange, a penetrating conductor inserted into this ceramic sleeve, and the ceramic sleeve and the penetrating conductor are coupled air-tightly to each other inside the flange (inside the tank) sealed outside the flange with a bellows of semi-mountain construction in cross section. The bellows has an elasticity and is mounted, when the ceramic sleeve and the penetrating conductor are linearly expanded at the maximum temperature during practical or normal use, or at the temperature slightly higher than the said level. The bellows is mounted between the ceramic sleeve and the penetrating conductor in a state where it is displaced to its maximum length due to its self elasticity. The bellows has been structured in such that it may absorb the reaction force being generated, when the penetrating conductor has linearly expanded, as a compression onto the side of ceramic sleeve for preventing it from acting as an tensile stress.

    摘要翻译： PCT No.PCT / JP90 / 00269 Sec。 371 1990年12月12日第 102（e）日期1990年12月12日PCT 1990年3月1日PCT公布。 出版物WO90 / 10330 日期1990年9月7日。供电单元用于向用于驱动潜水泵的电动机提供动力，该潜水泵将液体从储存诸如LNG之类的低温液体等的罐中舀出。 供电单元具有固定到凸缘的陶瓷套筒，插入该陶瓷套筒中的穿透导体，陶瓷套筒和穿透导体在密封在凸缘外部的凸缘（内部）内彼此气密地联接 横断面半山建筑的波纹管。 波纹管具有弹性，并且当陶瓷套筒和穿透导体在实际或正常使用期间在最高温度下线性膨胀时，或者在略高于所述水平的温度下安装。 波纹管由于其自身弹性而被置于其最大长度的状态下安装在陶瓷套筒和穿透导体之间。 波纹管已经被构造成使得当穿透导体线性膨胀时，其可以吸收产生的反作用力作为压缩到陶瓷套筒的侧面上，以防止其作为拉伸应力。