摘要:
Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要:
Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R0, R5, R6, R7, n, Q1-Q5, Y, and X1-X3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要:
The current invention is directed toward compounds and pharmaceutically acceptable salts of Formula I wherein Q1 is CR1, Q2 is N, Q4 and Q5 are each CR1, Q3 is CR2, X1 is N or CRc, Y is CRc, X2 and X3 are each C(R5)(R6), R7 is O. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer The current invention is also directed toward pharmaceutical compositions comprising compounds of the invention.
摘要:
Disclosed are compounds and pharmaceutically acceptable salts of Formula I, wherein A, R7, X1, X2, X3, Y, and n are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要:
The invention provides indole and indazole compounds of Formula (I) or pharmaceutically acceptable salts thereof which are useful for treating and/or preventing diseases and/or disorders ameliorated by the inhibition of Heat-Shock Protein 90. The invention further provides pharmaceutical compositions comprising compounds of Formula (I) and methods of preparing compounds of Formula (I).
摘要:
The disclosure discloses a method for processing/testing of a called terminal and a Long Time Evolution (LTE) system. The method comprises that: a network side of the LTE system sends a paging message to the terminal residing in an LTE cell which is called by a Circuit Switched (CS) domain service; the terminal establishes a Radio Resource Control (RRC) connection with the network side; the terminal sends to the network side a message for requesting to establish a CS domain service; the network side indicates, to the terminal, carrier frequency information of a Global System for Mobile Communications (GSM) cell to which the terminal needs to be redirected; the terminal sends a channel request message to the GSM cell; the terminal performs routing area updating in the GSM cell; the terminal sends a paging response message to the GSM cell; the terminal establishes the CS domain service in the GSM cell. By using the disclosure, when being called by the CS domain service, the terminal residing in the LTE cell can return to a cell of a corresponding network to establish the CS domain service.
摘要:
A system and method for processing close talking differential microphone array (CTDMA) signals in which incoming microphone signals are transformed from time domain signals to frequency domain signals having separable magnitude and phase information. Processing of the frequency domain signals is performed using the magnitude information, following which phase information is reintroduced using phase information of one of the original frequency domain signals. As a result, high pass filtering effects of conventional differential signal processing of CTDMA signals are substantially avoided.
摘要:
A system includes multiple speakers arranged in a speaker array configuration. The system also includes one or more filters configured to filter audio signals and generate filtered audio signals. The one or more filters are configured to operate using filter coefficients associated with a desired beam pattern to be produced by the multiple speakers. The system further includes at least one amplifier configured to amplify the filtered audio signals and provide the amplified filtered audio signals to the speakers. The one or more filters reside within or are coupled to the at least one amplifier. The system may further include a controller configured to modify at least one of the filter coefficients based on a change in the speaker configuration. The filters may operate independently of a centralized processor, and a centralized processor may not even be required to provide electronic beam forming.
摘要:
A rotational micro-actuator (20) used in hard disk driver is disclosed. It comprises a frame (21) approximately in the shape of letter “S” and PZT pieces (28, 29) attached to said frame (21), wherein said frame (21) is formed with a central coupling portion (213) by which the micro-actuator (20) is coupled to a suspension tongue (177), and two pieces of said PZT (28, 29) are arranged in central symmetry manner about said central coupling portion (213) such that said micro-actuator (20) can rotate about said central coupling portion (213) in response to the driving signals applied to said PZT pieces (28, 29), thus cause the displacement of the head element secured to the micro-actuator (20) so as to achieve the fine positioning of the head element. With above configuration, the micro-actuator of this invention will not cause the resonance of the suspension base plate during operation. Thereby the servo bandwidth of the hard disk driver is expanded.
摘要:
A synchronous detection and calibration system is provided for expedient calibration of differential acoustic sensors in a manufacturing and testing environment. By processing a series of sequentially received tones, respective portions of a system using differential acoustic sensors are tuned for optimum individual operation, following which corresponding control data are generated and stored for use in selecting among predetermined calibration vectors which establish and maintain optimum system operation.