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公开(公告)号：US06369197B1
公开(公告)日：2002-04-09
申请号：US09298731
申请日：1999-04-23
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wengian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wengian An
IPC分类号： C07K1400
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07041795B2
公开(公告)日：2006-05-09
申请号：US10118590
申请日：2002-04-08
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wengian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wengian An
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07556938B1
公开(公告)日：2009-07-07
申请号：US09703094
申请日：2000-10-31
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07439029B2
公开(公告)日：2008-10-21
申请号：US10106989
申请日：2002-03-25
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： G01N33/53
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US06689581B1
公开(公告)日：2004-02-10
申请号：US09350614
申请日：1999-07-09
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： C12N1512
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。
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6.发明授权Nucleic acid molecules encoding potassium channel interactors and uses therefor 有权编码钾通道相互作用的核酸分子及其用途公开(公告)号：US06361971B1
公开(公告)日：2002-03-26
申请号：US09399913
申请日：1999-09-21
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： C12N1512
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07078481B1
公开(公告)日：2006-07-18
申请号：US09670756
申请日：2000-09-27
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： C07K14/00 , C07K14/435
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US20050277761A1
公开(公告)日：2005-12-15
申请号：US10118590
申请日：2002-04-08
申请人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
发明人： Kenneth Rhodes , Maria Betty , Huai-Ping Ling , Wenqian An
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07H21/04 , C07K14/705
摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。
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9.发明申请CLONING, CHARACTERIZATION, AND APPLICATION OF TNFRSF19 IN NEUROLOGICAL DISORDERS 审中-公开克隆，表征和应用TNFRSF19在神经疾病中的作用公开(公告)号：US20070186296A1
公开(公告)日：2007-08-09
申请号：US11670705
申请日：2007-02-02
申请人： Ying Gao , Huai-Ping Ling , Andrew Wood , Kodangattil Sreekumar
发明人： Ying Gao , Huai-Ping Ling , Andrew Wood , Kodangattil Sreekumar
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12N5/06 , C07K14/715
CPC分类号： C07K14/70578 , C07K2319/41
摘要： TNFRSF19 nucleic acids and proteins, TNFRSF19 binding partners and modulators, and methods of using the same.
摘要翻译： TNFRSF19核酸和蛋白质，TNFRSF19结合配偶体和调节剂及其使用方法。
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