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    Nucleic acids encoding potassium channel interactors
    1.
    发明授权
    Nucleic acids encoding potassium channel interactors 有权
    编码钾通道相互作用的核酸

    公开(公告)号：US07556938B1

    公开(公告)日：2009-07-07

    申请号：US09703094

    申请日：2000-10-31

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N15/63 ,  C12N5/10

    CPC分类号： C07K14/47

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。

    Human 9q polypeptides method
    2.
    发明授权
    Human 9q polypeptides method 失效
    人9q多肽方法

    公开(公告)号：US07439029B2

    公开(公告)日：2008-10-21

    申请号：US10106989

    申请日：2002-03-25

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。

    Treatment of inflammatory disorders
    3.
    发明申请
    Treatment of inflammatory disorders 审中-公开

    公开(公告)号：US20060276440A1

    公开(公告)日：2006-12-07

    申请号：US11325615

    申请日：2006-01-03

    申请人： Wenqian An ,  Jun Park ,  Mehran Khodadoust ,  Hans-Jurgen Hess ,  Md. Hussom

    发明人： Wenqian An ,  Jun Park ,  Mehran Khodadoust ,  Hans-Jurgen Hess ,  Md. Hussom

    IPC分类号： A61K31/57 ,  A61K31/517 ,  A61K31/428 ,  A61K31/366 ,  A61K31/203

    CPC分类号： A61K31/203 ,  A61K31/05 ,  A61K31/09 ,  A61K31/165 ,  A61K31/19 ,  A61K31/343 ,  A61K31/365 ,  A61K31/366 ,  A61K31/37 ,  A61K31/415 ,  A61K31/428 ,  A61K31/498 ,  A61K31/517 ,  A61K31/56 ,  A61K31/57 ,  C07F9/12

    摘要： Methods of treating an inflammatory disorder include administering an effective amount of a compound represented by Structural Formula (I): Ring A is optionally substituted, contains zero, one, two, or three double bonds, and is optionally fused to an aliphatic, aryl or heteroaryl ring; X is an optionally substituted 1 to 3 carbon aliphatic chain that is optionally fused to a monocyclic, optionally substituted, aliphatic, heterocyclic, aryl, or heteroaryl ring, wherein one or two carbons in X are optionally replaced with —O—, —S—, or —NRe—; Y is carbon or nitrogen; R1 and R2 are independently —H, —OH, —CN, —NO2, —NRfRg, halogen, optionally substituted alkyl, or optionally substituted alkoxy; or R1 and R2 together link the carbons to which they are bonded with a bond, —O—, —S—, or —NRh—; R3 and R4 are independently —H, —OH, —CN, —NO2, —NRiRj, halogen, optionally substituted alkyl, or optionally substituted alkoxy, or R4 is ═O; or R3 and R4, taken together with the atoms to which they are bonded, form a monocyclic, optionally substituted, aliphatic, heterocyclic, aryl, or heteroaryl ring that is optionally fused to a monocyclic or bicyclic, optionally substituted, aliphatic, heterocyclic, aryl, or heteroaryl ring; Re-Rj are independently —H or optionally substituted alkyl; and each of the OSM signaling inhibitor compounds has at least one hydrogen atom bonded to an oxygen, nitrogen, or sulfur atom. The OSM signaling inhibitor compounds also include pharmaceutically acceptable salt or solvates of the compounds represented by Structural Formula (I).

    Potassium channel interactors and uses therefor
    5.
    发明授权
    Potassium channel interactors and uses therefor 有权
    钾通道相互作用及其用途

    公开(公告)号：US06689581B1

    公开(公告)日：2004-02-10

    申请号：US09350614

    申请日：1999-07-09

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： C12N1512

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。

    Nucleic acid molecules encoding potassium channel interactors and uses therefor
    6.
    发明授权
    Nucleic acid molecules encoding potassium channel interactors and uses therefor 有权
    编码钾通道相互作用的核酸分子及其用途

    公开(公告)号：US06361971B1

    公开(公告)日：2002-03-26

    申请号：US09399913

    申请日：1999-09-21

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： C12N1512

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。

    Potassium channel interactors and uses therefor
    8.
    发明授权
    Potassium channel interactors and uses therefor 有权

    公开(公告)号：US07078481B1

    公开(公告)日：2006-07-18

    申请号：US09670756

    申请日：2000-09-27

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： C07K14/00 ,  C07K14/435

    CPC分类号： C07K14/47

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    POTASSIUM CHANNEL INTERACTORS POLYPEPTIDES AND USES THEREOF
    9.
    发明申请
    POTASSIUM CHANNEL INTERACTORS POLYPEPTIDES AND USES THEREOF 有权
    钾通道相互作用聚合物及其用途

    公开(公告)号：US20050277761A1

    公开(公告)日：2005-12-15

    申请号：US10118590

    申请日：2002-04-08

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C07H21/04 ,  C07K14/705

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。