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    Methods and compositions for treating ophthalmic conditions with retinyl derivatives
    1.
    发明授权
    Methods and compositions for treating ophthalmic conditions with retinyl derivatives 失效
    用视黄醇衍生物治疗眼科疾病的方法和组合物

    公开(公告)号：US08410168B2

    公开(公告)日：2013-04-02

    申请号：US12764764

    申请日：2010-04-21

    申请人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    发明人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    IPC分类号： A01N47/10 ,  A01N47/28 ,  A01N47/40 ,  A61K31/27 ,  A61K31/275

    CPC分类号： A61K31/167 ,  A61K31/16 ,  A61K31/215 ,  G01N2800/164

    摘要： Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

    摘要翻译： 引起可逆性夜盲症的化合物可用于治疗与视觉循环过程中积累的废物过量生产相关的眼科疾病。 我们描述使用这些化合物及其衍生物治疗例如黄斑变性和营养不良的方法和组合，或减轻与这种眼科疾病相关的症状。 这些化合物及其衍生物可以用作单一药物治疗或与其它药物或疗法组合使用。

    METHODS, ASSAYS AND COMPOSITIONS FOR TREATING RETINOL-RELATED DISEASES
    3.
    发明申请
    METHODS, ASSAYS AND COMPOSITIONS FOR TREATING RETINOL-RELATED DISEASES 审中-公开
    方法，用于治疗相关疾病的测定和组合物

    公开(公告)号：US20120309835A1

    公开(公告)日：2012-12-06

    申请号：US13314035

    申请日：2011-12-07

    申请人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    发明人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    IPC分类号： A61K31/16 ,  A61P27/02

    CPC分类号： A61K31/165 ,  A61K31/16 ,  A61K31/56 ,  A61K45/06 ,  G01N2800/042 ,  G01N2800/164 ,  A61K2300/00

    摘要： Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject.

    摘要翻译： 本文描述了通过调节受试者中转甲状腺素蛋白（TTR）和视黄醇结合蛋白（RBP）可用性来治疗某些视黄醇相关疾病和病症的方法和组合物。 例如，该方法和组合物提供用于治疗和/或预防年龄相关性黄斑变性和/或营养不良，代谢紊乱，特发性颅内高血压，增生性骨折和蛋白质错折叠和聚集疾病的治疗剂。 所公开的组合物可用作单一药物治疗或与其它药物或疗法组合使用。 此外，本文描述了用于选择可以调节受试者的TTR和RBP可用性的适当试剂的方法和测定法。

    METHODS AND COMPOSITIONS FOR TREATING OPTHALMIC CONDITIONS WITH RETINOL DERIVATIVES
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING OPTHALMIC CONDITIONS WITH RETINOL DERIVATIVES 审中-公开
    用维生素D衍生物处理适宜条件的方法和组合物

    公开(公告)号：US20110294891A1

    公开(公告)日：2011-12-01

    申请号：US13118330

    申请日：2011-05-27

    申请人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    发明人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    IPC分类号： A61K31/167 ,  A61P27/02

    CPC分类号： A61K31/167 ,  A61K31/16 ,  A61K31/215 ,  G01N2800/164

    摘要： Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

    摘要翻译： 引起可逆性夜盲症的化合物可用于治疗与视觉循环过程中积累的废物过量生产相关的眼科疾病。 我们描述使用这些化合物及其衍生物治疗例如黄斑变性和营养不良的方法和组合，或减轻与这种眼科疾病相关的症状。 这些化合物及其衍生物可以用作单一药物治疗或与其它药物或疗法组合使用。

    Methods and compositions for treating ophthalmic conditions with retinyl derivatives
    7.
    发明授权
    Methods and compositions for treating ophthalmic conditions with retinyl derivatives 有权
    用视黄醇衍生物治疗眼科疾病的方法和组合物

    公开(公告)号：US08314152B2

    公开(公告)日：2012-11-20

    申请号：US11150641

    申请日：2005-06-10

    申请人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    发明人： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

    IPC分类号： A01N33/18 ,  A01N33/24 ,  A61K31/12

    CPC分类号： A61K31/167 ,  A61K31/16 ,  A61K31/215 ,  G01N2800/164

    摘要： Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

    摘要翻译： 引起可逆性夜盲症的化合物可用于治疗与视觉循环过程中积累的废物过量生产相关的眼科疾病。 我们描述使用这些化合物及其衍生物治疗例如黄斑变性和营养不良的方法和组合，或减轻与这种眼科疾病相关的症状。 这些化合物及其衍生物可以用作单一药物治疗或与其它药物或疗法组合使用。