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公开(公告)号：US09687653B2
公开(公告)日：2017-06-27
申请号：US13538022
申请日：2012-06-29
申请人： Carla M. Woods , James R. Thacker , David K. Peterson , Holly A. Segel , Susan E. Ford , Margaret E. Theriot , Kerry Bradley
发明人： Carla M. Woods , James R. Thacker , David K. Peterson , Holly A. Segel , Susan E. Ford , Margaret E. Theriot , Kerry Bradley
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/36185 , A61N1/37241 , A61N1/37247
摘要： A programming system for selecting an electrode configuration for use in a medical electrical stimulator coupled to an electrode array. A programmer is configured for providing a set of electrode configurations for the electrode array, automatically testing a first portion of the set of electrode configurations in a first order, allowing the selection of one or more of the tested electrode configurations, determining whether a suitable number of electrode configurations from among the first portion have been selected within a predefined interval, and automatically testing a second portion of the set of electrode configurations in a second order if the suitable number of electrode configurations from among the first portion are not selected within the predefined interval. The programmer may further allow the selection of the tested electrode configurations, and adjusting parameters during the testing, wherein the adjusting is controllably shared in parallel between a clinician and a patient.
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公开(公告)号：US08233991B2
公开(公告)日：2012-07-31
申请号：US11105643
申请日：2005-04-13
申请人： Carla M. Woods , James R. Thacker , David K. Peterson , Holly A. Segel , Susan E. Ford , Margaret E. Theriot , Kerry Bradley
发明人： Carla M. Woods , James R. Thacker , David K. Peterson , Holly A. Segel , Susan E. Ford , Margaret E. Theriot , Kerry Bradley
IPC分类号： A61N1/04
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/36185 , A61N1/37241 , A61N1/37247
摘要： Methods for selecting Spinal Cord Stimulation (SCS), or other medical electrical stimulator, electrode configurations from a set of electrode configurations are provided. Each electrode configuration represents a polarity or a polarity percentage of the electrodes of an electrode array. The selected electrode configurations may be used in a medical electrical stimulator. Such methods of selecting electrode configurations results in a more efficient programming and use of the stimulation system.
摘要翻译： 提供了从一组电极配置中选择脊髓刺激（SCS）或其他医疗电刺激器电极配置的方法。 每个电极配置表示电极阵列的电极的极性或极性百分比。 所选择的电极配置可以用在医疗电刺激器中。 这种选择电极配置的方法导致更有效的编程和使用刺激系统。
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3.发明申请SYSTEM AND METHOD FOR CONVERTING TISSUE STIMULATION PROGRAMS IN A FORMAT USABLE BY AN ELECTRICAL CURRENT STEERING NAVIGATOR 有权用于电流转向导管可用的格式转换组织刺激方案的系统和方法公开(公告)号：US20100010566A1
公开(公告)日：2010-01-14
申请号：US12501282
申请日：2009-07-10
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36146 , A61N1/3615 , A61N1/36167 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63
摘要： A method, computer medium, and system for programming a controller is provided. The controller controls electrical stimulation energy output to electrodes, and stores a set of programmed stimulation parameters associated with the electrodes. The programmed stimulation parameter set is compared with sets of reference stimulation parameters, each of the reference sets of stimulation parameters being associated with the electrodes. If an identical match is determined between the programmed stimulation parameter set and any one of the reference stimulation parameter sets exists based on the comparison, the identically matched stimulation parameter set is selected as an initial stimulation parameter set. If an identical match does not exist, a best between the programmed stimulation parameter set and the reference stimulation parameter sets is determined and selected as the initial stimulation parameter set. The controller is then programmed with a new set of programmable stimulation parameters based on the initial stimulation parameter set.
摘要翻译： 提供了一种用于编程控制器的方法，计算机介质和系统。 控制器控制对电极的电刺激能量输出，并且存储与电极相关联的一组编程的刺激参数。 将编程的刺激参数集与参考刺激参数的集合进行比较，每个参考组的刺激参数与电极相关联。 如果在编程的刺激参数集之间确定相同的匹配，并且基于比较存在参考刺激参数集中的任一个，则选择相同匹配的刺激参数集作为初始刺激参数集。 如果不存在相同的匹配，则确定编程的刺激参数集和参考刺激参数集之间的最佳值，并将其选为初始刺激参数集。 然后基于初始刺激参数集，控制器用一组新的可编程刺激参数进行编程。
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4.发明授权公开(公告)号：US06993384B2
公开(公告)日：2006-01-31
申请号：US10310202
申请日：2002-12-03
申请人： Kerry Bradley , James R. Thacker
发明人： Kerry Bradley , James R. Thacker
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551
摘要： Interelectrode impedance or electric field potential measurements are used to determine the relative orientation of one lead to other leads in the spinal column or other body/tissue location. Interelectrode impedance is determined by measuring impedance vectors. The value of the impedance vector is due primarily to the electrode-electrolyte interface, and the bulk impedance between the electrodes. The bulk impedance between the electrodes is, in turn, made up of (1) the impedance of the tissue adjacent to the electrodes, and (2) the impedance of the tissue between the electrodes. In one embodiment, the present invention makes both monopolar and bipolar impedance measurements, and then corrects the bipolar impedance measurements using the monopolar measurements to eliminate the effect of the impedance of the tissue adjacent the electrodes. The orientation and position of the leads may be inferred from the relative minima of the corrected bipolar impedance values. These corrected impedance values may also be mapped and stored to facilitate a comparison with subsequent corrected impedance measurement values. Such comparison allows a determination to be made as to whether the lead position and/or orientation has changed appreciably over time. In another embodiment, one or more electrodes are stimulated and the resulting electric field potential on the non-stimulated electrodes is measured. Such field potential measurements provide an indication of the relative orientation of the electrodes. Once known, the relative orientation may be used to track lead migration, to setup stimulation configurations and parameters for nominal stimulation and/or navigation. Also, such measurements allow automatic adjustment of stimulation energy to a previously-defined optimal potential field in the case of lead migration or postural changes.
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5.发明授权Method of maintaining intensity output while adjusting pulse width or amplitude 有权调整脉冲宽度或幅度时保持强度输出的方法公开(公告)号：US09352161B2
公开(公告)日：2016-05-31
申请号：US11553447
申请日：2006-10-26
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36146 , A61N1/36171 , A61N1/36175
摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.
摘要翻译： 组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。 刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。 在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。 编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。
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6.发明申请METHOD OF MAINTAINING INTENSITY OUTPUT WHILE ADJUSTING PULSE WIDTH OR AMPLITUDE 有权在调节脉冲宽度或幅度时维持强度输出的方法公开(公告)号：US20080103559A1
公开(公告)日：2008-05-01
申请号：US11553447
申请日：2006-10-26
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36146 , A61N1/36171 , A61N1/36175
摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.
摘要翻译： 组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。 刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。 在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。 编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。
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7.发明授权Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权用于确定神经刺激导联的相对位置和取向的装置和方法公开(公告)号：US09192760B2
公开(公告)日：2015-11-24
申请号：US12856905
申请日：2010-08-16
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551 , A61N1/3605 , A61N1/37247
摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.
摘要翻译： 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。
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8.发明授权Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权用于确定神经刺激导联的相对位置和取向的装置和方法公开(公告)号：US08682447B2
公开(公告)日：2014-03-25
申请号：US11343007
申请日：2006-01-30
申请人： Kerry Bradley , James R. Thacker
发明人： Kerry Bradley , James R. Thacker
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551
摘要： Interelectrode impedance or electric field potential measurements are used to determine the relative orientation of one lead to other leads in the spinal column or other body/tissue location. Interelectrode impedance is determined by measuring impedance vectors. The value of the impedance vector is due primarily to the electrode-electrolyte interface, and the bulk impedance between the electrodes. The bulk impedance between the electrodes is, in turn, made up of (1) the impedance of the tissue adjacent to the electrodes, and (2) the impedance of the tissue between the electrodes. In one embodiment, the present invention makes both monopolar and bipolar impedance measurements, and then corrects the bipolar impedance measurements using the monopolar measurements to eliminate the effect of the impedance of the tissue adjacent the electrodes. The orientation and position of the leads may be inferred from the relative minima of the corrected bipolar impedance values. These corrected impedance values may also be mapped and stored to facilitate a comparison with subsequent corrected impedance measurement values.
摘要翻译： 使用内电极阻抗或电场电位测量来确定一个引线与脊柱或其他身体/组织位置中的其它引线的相对取向。 内部电阻阻抗通过测量阻抗矢量来确定。 阻抗矢量的值主要是由于电极 - 电解质界面和电极之间的体阻抗。 电极之间的体阻抗又由（1）与电极相邻的组织的阻抗，和（2）电极之间的组织的阻抗构成。 在一个实施例中，本发明进行单极性和双极性阻抗测量，然后使用单极测量来校正双极性阻抗测量，以消除邻近电极的组织的阻抗的影响。 引线的取向和位置可以从校正的双极性阻抗值的相对最小值推断。 这些校正的阻抗值也可以被映射和存储，以便于与随后校正的阻抗测量值进行比较。
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9.发明授权公开(公告)号：US07881805B2
公开(公告)日：2011-02-01
申请号：US11026859
申请日：2004-12-30
申请人： Kerry Bradley , James R. Thacker , Carla M. Woods , John D. King
发明人： Kerry Bradley , James R. Thacker , Carla M. Woods , John D. King
IPC分类号： A61N1/04
CPC分类号： A61N1/36071 , A61N1/0551 , Y10S128/92
摘要： A method for transitioning electrical energy in steps between electrodes implanted within a patient to stimulate tissue (e.g., spinal cord tissue) is provided. The method comprises determining a maximum comfortable step size, determining a minimum step size, selecting one or more step sizes between the maximum comfortable step size and the minimize step size, and transitioning the electrical energy between the electrodes using the selected one or more step sizes.
摘要翻译： 提供了一种用于在植入患者体内的电极之间跨步电能以刺激组织（例如脊髓组织）的方法。 该方法包括确定最大舒适步长，确定最小步长，选择最大舒适步长和最小化步长之间的一个或多个步长，以及使用所选择的一个或多个步长来转换电极之间的电能 。
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10.发明申请APPARATUS AND METHOD FOR DETERMINING THE RELATIVE POSITION AND ORIENTATION OF NEUROSTIMULATION LEADS 审中-公开用于确定相对位置和神经细胞导向方位的装置和方法公开(公告)号：US20100305631A1
公开(公告)日：2010-12-02
申请号：US12856905
申请日：2010-08-16
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61B5/053 , A61N1/0551 , A61N1/3605 , A61N1/37247
摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.
摘要翻译： 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。
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