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    Process for preparation of phenethylamine derivatives
    1.
    发明授权
    Process for preparation of phenethylamine derivatives 失效
    苯乙胺衍生物的制备方法

    公开(公告)号：US07563931B2

    公开(公告)日：2009-07-21

    申请号：US11708283

    申请日：2007-02-20

    申请人： Keun-Sik Kim ,  Kwang-Il Kim ,  Ki-Byung Chai

    发明人： Keun-Sik Kim ,  Kwang-Il Kim ,  Ki-Byung Chai

    IPC分类号： C07C209/48

    CPC分类号： C07C213/02 ,  C07C2601/14 ,  C07C215/42 ,  C07C217/74

    摘要： A process for the preparation of a compound of formula I, wherein R1 and R2 are ortho or para substituents, independently selected from the group consisting of hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C7-C9 aralkoxy, C2-C7 alkanoyloxy, C1-C6 alkylmercapto, halo and trifluoromethyl; R3 is hydrogen or C1-C6 alkyl; R4 is hydrogen, C1-C6 alkyl, formyl or C2-C7 alkanoyl; n is one of the integers 0, 1, 2, 3 or 4; and the dotted line represents optional olefinic unsaturation; comprising hydrogenating a compound of formula III, in the presence of a nickel or cobalt catalyst at a temperature of about 5° C. to 25° C.

    摘要翻译： 一种制备式I化合物的方法，其中R 1和R 2是独立地选自氢，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，C 7 -C 9芳烷氧基，C 2 -C 6烷氧基， C7烷酰氧基，C1-C6烷基巯基，卤素和三氟甲基; R3是氢或C1-C6烷基; R4是氢，C1-C6烷基，甲酰基或C2-C7烷酰基; n是整数0,1,2,3或4之一; 并且虚线表示任选的烯属不饱和键; 包括在约5℃至25℃的温度下，在镍或钴催化剂的存在下氢化式III的化合物。

    Process for preparation of phenethylamine derivatives
    2.
    发明申请
    Process for preparation of phenethylamine derivatives 失效
    苯乙胺衍生物的制备方法

    公开(公告)号：US20070149813A1

    公开(公告)日：2007-06-28

    申请号：US11708283

    申请日：2007-02-20

    申请人： Keun-Sik Kim ,  Kwang-II Kim ,  Ki-Byung Chai

    发明人： Keun-Sik Kim ,  Kwang-II Kim ,  Ki-Byung Chai

    IPC分类号： C07C209/48

    CPC分类号： C07C213/02 ,  C07C2601/14 ,  C07C215/42 ,  C07C217/74

    摘要： A process for the preparation of a compound of formula I, wherein R1 and R2 are ortho or para substituents, independently selected from the group consisting of hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C7-C9 aralkoxy, C2-C7 alkanoyloxy, C1-C6 alkylmercapto, halo and trifluoromethyl; R3 is hydrogen or C1-C6 alkyl; R4 is hydrogen, C1-C6 alkyl, formyl or C2-C7 alkanoyl; n is one of the integers 0, 1, 2, 3 or 4; and the dotted line represents optional olefinic unsaturation; comprising hydrogenating a compound of formula III, in the presence of a nickel or cobalt catalyst at a temperature of about 5° C. to 25° C.

    摘要翻译： 制备式I化合物的方法，其中R 1和R 2是邻或对位取代基，其独立地选自氢，羟基，C C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基， -C 9芳烷氧基，C 2 -C 7烷酰氧基，C 1 -C 6烷基， 烷基巯基，卤代和三氟甲基; R 3是氢或C 1 -C 6烷基; R 3是氢或C 1 -C 6烷基; R 4是氢，C 1 -C 6烷基，甲酰基或C 2 -C 7 烷酰基; n是整数0,1,2,3或4之一; 并且虚线表示任选的烯属不饱和键; 包括在约5℃至25℃的温度下，在镍或钴催化剂的存在下氢化式III的化合物。

    ONE-TIME-USE AUTOMATIC SAFETY INJECTOR
    5.
    发明申请
    ONE-TIME-USE AUTOMATIC SAFETY INJECTOR 审中-公开
    一次性使用自动安全注射器

    公开(公告)号：US20100234803A1

    公开(公告)日：2010-09-16

    申请号：US12300317

    申请日：2007-04-27

    申请人： Keun-Sik Kim ,  Tae-Sung Park

    发明人： Keun-Sik Kim ,  Tae-Sung Park

    IPC分类号： A61M5/50

    CPC分类号： A61M5/322 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/5066 ,  A61M2005/31516 ,  A61M2005/3231 ,  A61M2005/5026

    摘要： Disclosed is a one-time use safety injector capable of easily removing a remaining solution in the administration of an injection solution and easily being detached and discarded after use. The automatic safety injector according to the present invention includes a needle flange 31 having a needle 30 mounted in the front thereof and a cone inner space 32 and an edge portion 33 formed in the rear thereof, a coupling ring 50 being inserted into a circumferential edge of the edge portion 33; an adapter 60 including a hanging projection 61, a cone protrusion 62, coupling ring insertion grooves 63, a spherical flange 64 and a gasket 70, the gasket 70 being inserted from the front circumferential edge up to the hanging projection 61, the cone protrusion 62 being projected and installed in its head portion, the coupling ring insertion grooves 63 being formed around the cone protrusion 62, and the spherical flange 64 being formed in the front of the adapter 60; a piston 40 including elastic wings 41,41′ and a spherical flange 42, the elastic wings 41,41′ being installed in both sides of the head portion of the piston 40, and the spherical flange 42 being projected and installed inside the piston 40; and an injector cylinder 20 having an injection solution inlet 21 formed in the front thereof and an adapter hanging projection 22 formed in the rear thereof.

    摘要翻译： 公开了一种一次性使用安全注射器，其能够容易地除去注射溶液的给药中的剩余溶液，并且在使用后容易分离和丢弃。 根据本发明的自动安全注射器包括具有安装在其前面的针30的针法兰31和形成在其后部的锥形内部空间32和边缘部33，连接环50插入周边 的边缘部33; 包括悬挂突起61，锥形突起62，联接环插入槽63，球形凸缘64和垫圈70的适配器60，垫圈70从前周缘插入悬挂突起61，锥形突起62 突出并安装在其头部中，联接环插入槽63围绕锥形突起62形成，并且球形凸缘64形成在适配器60的前部; 包括弹性翼41,41'和球形凸缘42的活塞40，弹性翼41,41'安装在活塞40的头部的两侧，并且球形凸缘42突出并安装在活塞40内 ; 以及具有形成在其前面的注射溶液入口21和形成在其后部的适配器悬挂突起22的注射器筒20。