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14 条记录 (耗时 0.035 秒)

    Releasable dovetail corner joint
    6.
    发明申请
    Releasable dovetail corner joint 失效
    可释放的燕尾角接头

    公开(公告)号：US20060188325A1

    公开(公告)日：2006-08-24

    申请号：US11061512

    申请日：2005-02-22

    申请人： Kevin Dolan

    发明人： Kevin Dolan

    IPC分类号： F16B1/00

    CPC分类号： F16B12/125 ,  F16B12/46 ,  F16B2200/30 ,  Y10T403/42 ,  Y10T403/4602 ,  Y10T403/7062 ,  Y10T403/7067 ,  Y10T403/7096 ,  Y10T403/73

    摘要： A corner leg assembly comprises two grooved mating elements divided longitudinally which when held together form the female groove portion of two dovetail joints, one on each side facing laterally 90 degrees apart. One of the corner elements is a substantially triangular corner leg having perpendicular outside surfaces and parallel lengthwise L-shaped grooves on a 45 degree inside surface. The second element is a clamp block which includes opposite-facing L-shaped side grooves corresponding (being the mirror image thereof) to the grooves on the corner leg. The clamp block is affixed down the middle of the corner leg along the inside surface by one or more clamping fasteners such as a screw or bolt which passes through the clamp block. By turning the fastener(s), the clamp block may be loosened or removed to vertically adjust a laterally-extending panel or rail member.

    摘要翻译： 角腿组件包括纵向分开的两个槽配合元件，当两个槽配合元件保持在一起形成两个燕尾接头的阴沟槽部分时，一个侧面朝向横向90度分开。 角部元件之一是在45度内表面上具有垂直外表面和平行纵向L形凹槽的基本上三角形的拐角支腿。 第二元件是一个夹紧块，它包括相对于（在其镜像上）相对于L形形状的侧槽与拐角腿上的凹槽。 夹紧块通过一个或多个夹紧紧固件（例如穿过夹紧块的螺钉或螺栓）沿着内表面固定在拐角腿的中部。 通过转动紧固件，可以松开或移除夹紧块，以垂直地调节横向延伸的面板或轨道构件。

    Methods of enhancing immune response in the intradermal compartment and compounds useful thereof
    9.
    发明申请
    Methods of enhancing immune response in the intradermal compartment and compounds useful thereof 审中-公开
    增强皮内隔室中的免疫应答的方法及其有用的化合物

    公开(公告)号：US20050281832A1

    公开(公告)日：2005-12-22

    申请号：US11006369

    申请日：2004-12-06

    申请人： Robert Campbell ,  Kevin Dolan ,  Jason Alarcon ,  John Mikszta ,  Wendy Woodley ,  Sheetal Mehta

    发明人： Robert Campbell ,  Kevin Dolan ,  Jason Alarcon ,  John Mikszta ,  Wendy Woodley ,  Sheetal Mehta

    IPC分类号： A61K31/7048 ,  A61K39/00 ,  A61K39/39 ,  A61K45/00 ,  A61K47/00 ,  G01N33/53

    CPC分类号： A61K39/39 ,  A61K31/7048 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55588 ,  C12N2760/16134 ,  Y02A50/388 ,  Y02A50/466

    摘要： The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations

    摘要翻译： 本发明涉及用于皮内递送抗原性或免疫原性试剂与一种或多种赋形剂组合的免疫原性组合物。 本发明的免疫原性组合物包含抗原或免疫原性试剂和至少一种充当佐剂的赋形剂，即一旦递送到受试者的皮肤的真皮内隔室，则增强对抗原或免疫原性试剂的免疫应答。 本发明的免疫原性组合物包含赋形剂，其当根据本发明施用于皮肤的皮内隔室时显示佐剂活性。 本发明的免疫原性组合物具有增强的功效，因为组合物的赋形剂引起无症状的皮肤刺激并将抗原呈递细胞募集到皮内区室，从而增强抗原呈递细胞的抗原或免疫原性的呈递和/或可用性。 本发明的免疫原性组合物的增强的功效可以在单次真皮内剂量之后产生治疗有效的免疫应答，具有比常规使用的更低剂量的抗原性或免疫原性试剂，并且不需要加强免疫

    Sprinkler assembly
    10.
    发明申请
    Sprinkler assembly 失效
    喷水器总成

    公开(公告)号：US20050121206A1

    公开(公告)日：2005-06-09

    申请号：US11032056

    申请日：2005-01-11

    申请人： Kevin Dolan

    发明人： Kevin Dolan

    IPC分类号： A62C37/11 ,  A62C35/00

    CPC分类号： A62C37/11 ,  Y10T137/1963

    摘要： A sprinkler assembly for controlling a fire situation includes at least one fluid conduit defining a flow passage including an inlet for receiving a fluid from a fluid source and at least one outlet for discharging the fluid, and a dispensing mechanism such as an open or closed sprinkler head for distributing water to a selected location. A fluid control apparatus is provided including a valve assembly having a valve seal which is moveable between a closed position blocking fluid flow through the conduit and an open position causing fluid flow through the conduit. The fluid control apparatus further includes an actuating mechanism including a valve actuator which is operatively connected to the valve assembly for causing movement of the valve seal to the open position upon release of the sealing force. A sensing mechanism is operatively connected to the valve assembly, the sensing mechanism being thermodynamically responsive to at least one of heat, smoke, infrared radiation and ultraviolet radiation emitted by a heat source.

    摘要翻译： 用于控制火灾情况的喷洒器组件包括限定流路的至少一个流体导管，该流动通道包括用于从流体源接收流体的入口和用于排出流体的至少一个出口，以及诸如打开或关闭的喷洒器 将水分配到选定位置。 提供了一种流体控制装置，其包括具有阀密封件的阀组件，所述阀门密封件可在封闭位置之间移动，所述闭合位置阻止流过所述导管的流体流动和使流体流过所述导管的打开位置。 流体控制装置还包括致动机构，其包括阀致动器，阀致动器可操作地连接到阀组件，用于在释放密封力时使阀密封件移动到打开位置。 感测机构可操作地连接到阀组件，感测机构对热源，热源，红外辐射和由热源发射的紫外线辐射中的至少一种进行热力学响应。