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公开(公告)号：US06462036B1
公开(公告)日：2002-10-08
申请号：US09573366
申请日：2000-05-17
申请人： Kevin J. Doyle , Paul Rafferty , Robert W. Steele , David J. Wilkins , Lee D. Arnold , Michael Hockley , Anna M. Ericsson , Nobuhiko Iwasaki , Nobuo Ogawa
发明人： Kevin J. Doyle , Paul Rafferty , Robert W. Steele , David J. Wilkins , Lee D. Arnold , Michael Hockley , Anna M. Ericsson , Nobuhiko Iwasaki , Nobuo Ogawa
IPC分类号： A61K3155
CPC分类号： C07D401/04 , C07D231/54 , C07D401/06 , C07D401/12 , C07D403/10 , C07D403/12 , C07D409/04 , C07D409/14 , C07D417/12 , C07D451/04 , C07D491/04 , C07D495/04
摘要： This invention relates to certain 3-aryl or 3-heteroaryl pyrazoles with 4,5(3,4)-bicyclic ring fusion which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.
摘要翻译： 本发明涉及某些3-芳基或3-杂芳基吡唑与具有蛋白激酶活性的抑制剂4,5（3,4） - 双环融合，其中一些是新化合物，含有这些吡唑的药物组合物和方法 用于制备这些吡唑。
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公开(公告)号：US07468371B2
公开(公告)日：2008-12-23
申请号：US11089473
申请日：2005-03-24
申请人： Lee D. Arnold , Jürgen Dinges , Richard W. Dixon , Stevan W. Djuric , Anna M. Ericsson , Kimba Fischer , Alan F. Gasiecki , Vijaya J. Gracias , James H. Holms , Makoto Takeshita , Michael R. Michaelides , Melanie A. Muckey , Paul Rafferty , Douglas H. Steinman , Carol K. Wada , Zhiren Xia , Irini Akritopoulou-Zanze , Henry Q. Zhang
发明人： Lee D. Arnold , Jürgen Dinges , Richard W. Dixon , Stevan W. Djuric , Anna M. Ericsson , Kimba Fischer , Alan F. Gasiecki , Vijaya J. Gracias , James H. Holms , Makoto Takeshita , Michael R. Michaelides , Melanie A. Muckey , Paul Rafferty , Douglas H. Steinman , Carol K. Wada , Zhiren Xia , Irini Akritopoulou-Zanze , Henry Q. Zhang
IPC分类号： A61K31/496 , A61K31/415 , C07D231/54 , C07D409/14
CPC分类号： C07D471/04 , C07D231/54 , C07D409/04 , C07D409/14 , C07D413/14 , C07D495/04 , C07D495/14
摘要： Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 本发明的化合物可用于抑制蛋白酪氨酸激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号：US07091227B2
公开(公告)日：2006-08-15
申请号：US09777554
申请日：2001-02-06
IPC分类号： A61K31/425 , C07D277/82
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D451/04 , C07D451/14 , C07D453/02 , C07D487/08 , C07D513/04
摘要： The present invention is directed to a compound of formula (I), racemic-diastereomeric mixtures thereof, optical isomers thereof, prodrugs thereof, isotopes thereof or pharmaceutically-acceptable salts of said compound, isomers, prodrugs and isotopes, wherein the variables are defined herein. The compounds of this invention are useful as inhibitors of serine/threonine and tyrosine kinases. In particular, compounds of this invention are useful as inhibitors of tyrosine kinases that are important in hyperproliferative diseases, especially in cancer and in the process of angiogenesis.
摘要翻译： 本发明涉及式（I）的化合物，其外消旋 - 非对映体混合物，其旋光异构体，其前体药物，其同位素或所述化合物，异构体，前药和同位素的药学上可接受的盐，其中变量在本文中定义 。 本发明的化合物可用作丝氨酸/苏氨酸和酪氨酸激酶的抑制剂。 特别地，本发明的化合物可用作酪氨酸激酶的抑制剂，其在过度增殖性疾病中尤为重要，特别是在癌症和血管发生过程中。
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公开(公告)号：US08962629B2
公开(公告)日：2015-02-24
申请号：US12481028
申请日：2009-06-09
申请人： Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael M. Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Kent D. Stewart , Grier A. Wallace , Lu Wang , Kevin R. Woller
发明人： Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Bryan A. Fiamengo , Kristine E. Frank , Michael M. Friedman , Dawn M. George , Eric R. Goedken , Nathan S. Josephsohn , Biqin C. Li , Kent D. Stewart , Grier A. Wallace , Lu Wang , Kevin R. Woller
IPC分类号： A61K31/495 , C07D513/14 , C07D487/14 , C07D498/14
CPC分类号： C07D487/14 , C07D498/14 , C07D513/14
摘要： The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20120022253A1
公开(公告)日：2012-01-26
申请号：US13248446
申请日：2011-09-29
申请人： Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
发明人： Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
IPC分类号： C07D413/02 , C07D401/02 , C07D211/08 , C07D231/56 , C07D261/20
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US20110152243A1
公开(公告)日：2011-06-23
申请号：US12974311
申请日：2010-12-21
申请人： Neil Wishart , Theresa Dunstan , Jeremy J. Edmunds , Anna M. Ericsson , Catherine R. Ferenz , Adrian D. Hobson , David C. Ihle , Kent D. Stewart , Lei Wang , Lu Wang
发明人： Neil Wishart , Theresa Dunstan , Jeremy J. Edmunds , Anna M. Ericsson , Catherine R. Ferenz , Adrian D. Hobson , David C. Ihle , Kent D. Stewart , Lei Wang , Lu Wang
IPC分类号： A61K31/397 , C07D401/14 , A61K31/517 , A61K31/496 , A61K31/454 , C07D487/04 , A61K31/53 , A61K31/437 , C07D403/14 , A61K31/416 , C07D471/04 , C07D413/14 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P1/04 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04
摘要： The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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![Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof](/abs-image/US/2014/07/22/US08785639B2/abs.jpg.150x150.jpg)
7.发明授权Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof 有权取代的二氢吡唑并[3,4-D]吡咯并[2,3-b]吡啶及其使用方法公开(公告)号：US08785639B2
公开(公告)日：2014-07-22
申请号：US12958291
申请日：2010-12-01
申请人： Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Kristine E. Frank , Dawn M. George , Eric R. Goedken , Michael Friedman , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Jeffrey W. Voss , Lu Wang , Eric C. Breinlinger , Kelly D. Mullen , Gagandeep Somal , Michael Z Hoemann
发明人： Neil Wishart , Maria A. Argiriadi , David J. Calderwood , Anna M. Ericsson , Kristine E. Frank , Dawn M. George , Eric R. Goedken , Michael Friedman , Nathan S. Josephsohn , Biqin C. Li , Michael J. Morytko , Jeffrey W. Voss , Lu Wang , Eric C. Breinlinger , Kelly D. Mullen , Gagandeep Somal , Michael Z Hoemann
IPC分类号： C07D471/00
CPC分类号： C07F9/06 , C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14
摘要： The invention provides a compound of Formula (Ie), pharmaceutically acceptable salts, or stereoisomers thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译： 本发明提供式（Ie）的化合物，其药学上可接受的盐或立体异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20090118298A1
公开(公告)日：2009-05-07
申请号：US12284758
申请日：2008-09-25
申请人： Dawn M. George , Lu Wang , Biqin Li , Anna M. Ericsson , Graham K. Ansell
发明人： Dawn M. George , Lu Wang , Biqin Li , Anna M. Ericsson , Graham K. Ansell
IPC分类号： A61K31/496 , C07D405/14 , A61K31/4375 , A61K31/4025 , A61K31/495 , A61K31/497 , A61P11/06 , A61P11/00 , A61P17/06 , A61P31/10 , A61P31/12 , A61P9/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P31/04 , A61P35/02 , A61P35/00 , A61P25/16 , A61P3/00 , A61P29/00 , A61P17/02 , A61P17/14 , A61P3/10 , A61P33/02 , A61P27/06 , A61P37/06 , A61P1/00 , A61P25/00 , A61P19/10 , C07D401/14 , C07D241/04 , C07D401/08 , C07D405/12
CPC分类号： C07D471/04 , C07D211/14 , C07D295/185 , C07D309/14 , C07D405/12
摘要： The present invention is directed to novel compounds of Formula (I) pharmaceutically acceptable salts thereof, pro-drugs thereof, biologically active metabolites thereof, isomers thereof or stereoisomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, osteoarthritis, multiple sclerosis and asthma.
摘要翻译： 本发明涉及新的式（I）化合物，其药学上可接受的盐，其前药，其生物活性代谢物，其异构体或其立体异构体，其中变量如本文所定义。 式（I）的化合物可用作趋化因子受体拮抗剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如类风湿性关节炎，骨关节炎，多发性硬化和哮喘。
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公开(公告)号：US08598199B2
公开(公告)日：2013-12-03
申请号：US13074676
申请日：2011-03-29
申请人： Dawn M. George , Lu X. Wang , Biqin Li , Anna M. Ericsson , Graham K. Ansell
发明人： Dawn M. George , Lu X. Wang , Biqin Li , Anna M. Ericsson , Graham K. Ansell
IPC分类号： A01N43/42 , A61K31/44 , C07D221/02
CPC分类号： C07D471/04 , C07D211/14 , C07D295/185 , C07D309/14 , C07D405/12
摘要： The present invention is directed to novel compounds of Formula (I) pharmaceutically acceptable salts thereof, pro-drugs thereof, biologically active metabolites thereof, isomers thereof or stereoisomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, osteoarthritis, multiple sclerosis and asthma.
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公开(公告)号：US08063091B2
公开(公告)日：2011-11-22
申请号：US12507575
申请日：2009-07-22
申请人： Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
发明人： Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
IPC分类号： A61K31/415 , C07D231/56
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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