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公开(公告)号：US20100241190A1
公开(公告)日：2010-09-23
申请号：US12739413
申请日：2008-10-28
申请人： Kevin L. Kilgore , Niloy Bhadra
发明人： Kevin L. Kilgore , Niloy Bhadra
IPC分类号： A61N1/00
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/20 , A61N1/205 , A61N1/32 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36103 , A61N1/3615 , A61N1/36167
摘要： A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time.
摘要翻译： 通过具有降低的发作活性的神经阻断信号传递的方法包括将HFAC应用于神经轴突以阻止通过轴突的信号传递。 该方法还可以包括向轴突施加直流电（DC），将DC随时间的幅度增加到预定的幅度，应用HFAC，然后减小DC。 该方法还可以包括临时减小HFAC的幅度以允许通过轴突的信号传输，并随后增加幅度以阻止传输而不触发起始响应。 该方法还可以包括暂时对神经施加不平衡电荷，然后随着时间平衡电荷。
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公开(公告)号：US08983614B2
公开(公告)日：2015-03-17
申请号：US12739413
申请日：2008-10-28
申请人： Kevin L. Kilgore , Niloy Bhadra
发明人： Kevin L. Kilgore , Niloy Bhadra
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/20 , A61N1/205 , A61N1/32 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36103 , A61N1/3615 , A61N1/36167
摘要： A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time.
摘要翻译： 通过具有降低的发作活性的神经阻断信号传递的方法包括将HFAC应用于神经轴突以阻止通过轴突的信号传递。 该方法还可以包括向轴突施加直流电（DC），将DC随时间的幅度增加到预定的幅度，应用HFAC，然后减小DC。 该方法还可以包括临时减小HFAC的幅度以允许通过轴突的信号传输，并随后增加幅度以阻止传输而不触发起始响应。 该方法还可以包括暂时对神经施加不平衡电荷，然后随着时间平衡电荷。
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公开(公告)号：US08843188B2
公开(公告)日：2014-09-23
申请号：US12948848
申请日：2010-11-18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/36185
摘要： Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode also includes a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.
摘要翻译： 描述可调电极示例。 一个示例性可调节电极包括两个或更多个触点，其被配置为以足以在神经中产生HFAC神经传导阻滞的量向神经选择性地递送高频交流电（HFAC）。 示例性可调节电极还包括被配置为选择性地控制两个或多个触点中的哪一个将HFAC递送到神经以控制神经电极是否处于第一（例如起始应答缓解）配置或第二次（例如，HFAC） 神经传导阻滞维持）配置。 电极可用于包括但不限于神经阻滞应用和神经刺激应用的应用中。 可以通过改变属性来调节电极，包括但不限于数量，长度，取向，距离，表面积以及与用于递送HFAC的接触的神经的距离。
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公开(公告)号：US20080294221A1
公开(公告)日：2008-11-27
申请号：US12214256
申请日：2008-06-17
申请人： Kevin Kilgore , Niloy Bhadra
发明人： Kevin Kilgore , Niloy Bhadra
CPC分类号： A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： An example method for selectively and reversibly preventing the conduction of action potentials in a targeted nerve region is presented. The method includes generating an electrical waveform having two phases and selectively depolarizing a nerve membrane using the electrical waveform. The nerve membrane is depolarized to a state where the nerve membrane cannot conduct an action potential. The depolarization is achieved by selectively repetitively providing the electrical waveform to a targeted nerve region associated with the nerve region to control m gates and h gates in the region and thus to control the availability of ions.
摘要翻译： 提出了选择性地和可逆地防止目标神经区域中动作电位传导的示例性方法。 该方法包括产生具有两相的电波形并且使用电波形选择性去极化神经膜。 神经膜被去极化到神经膜不能发挥动作电位的状态。 通过选择性地将电波形重复地提供给与神经区域相关联的目标神经区域来控制该区域中的m个门极和h个门，从而控制离子的可用性来实现去极化。
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公开(公告)号：US09008800B2
公开(公告)日：2015-04-14
申请号：US12949074
申请日：2010-11-18
CPC分类号： A61N1/0551 , A61L31/048 , A61N1/0436 , A61N1/0556 , A61N1/325 , A61N1/36067 , A61N1/36103
摘要： Example ionic coupling electrodes are described. One example ionic conducting electrode includes a first portion that can be coupled to a single phase current source. The first portion carries current flow via electrons. The electrode includes a second portion to apply a current to a nerve tissue. The second portion carries current flow via ions. The second portion is positioned between the nerve tissue and the first portion to prevent the first portion from touching the nerve tissue. The current applied to the nerve tissue is produced in the second portion in response to a current that is present in the first portion. The current present in the first portion is provided from a single phase current source. The electrode may be used in applications including, but not limited to, nerve block applications and nerve stimulation applications.
摘要翻译： 示例性的离子耦合电极被描述。 一个示例性的离子导电电极包括可以耦合到单相电流源的第一部分。 第一部分通过电子传送电流。 电极包括将电流施加到神经组织的第二部分。 第二部分通过离子传送电流。 第二部分位于神经组织和第一部分之间，以防止第一部分接触神经组织。 响应于存在于第一部分中的电流，在第二部分中产生施加到神经组织的电流。 第一部分中存在的电流由单相电流源提供。 电极可用于包括但不限于神经阻滞应用和神经刺激应用的应用中。
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公开(公告)号：US08060208B2
公开(公告)日：2011-11-15
申请号：US12214256
申请日：2008-06-17
申请人： Kevin Kilgore , Niloy Bhadra
发明人： Kevin Kilgore , Niloy Bhadra
IPC分类号： A61N1/34
CPC分类号： A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： An example method for selectively and reversibly preventing the conduction of action potentials in a targeted nerve region is presented. The method includes generating an electrical waveform having two phases and selectively depolarizing a nerve membrane using the electrical waveform. The nerve membrane is depolarized to a state where the nerve membrane cannot conduct an action potential. The depolarization is achieved by selectively repetitively providing the electrical waveform to a targeted nerve region associated with the nerve region to control m gates and h gates in the region and thus to control the availability of ions.
摘要翻译： 提出了选择性地和可逆地防止目标神经区域中动作电位传导的示例性方法。 该方法包括产生具有两相的电波形并且使用电波形选择性去极化神经膜。 神经膜被去极化到神经膜不能发挥动作电位的状态。 通过选择性地将电波形重复地提供给与神经区域相关联的目标神经区域来控制该区域中的m个门极和h个门，从而控制离子的可用性来实现去极化。
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公开(公告)号：US20110160798A1
公开(公告)日：2011-06-30
申请号：US12949074
申请日：2010-11-18
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61L31/048 , A61N1/0436 , A61N1/0556 , A61N1/325 , A61N1/36067 , A61N1/36103
摘要： Example ionic coupling electrodes are described. One example ionic conducting electrode includes a first portion that can be coupled to a single phase current source. The first portion carries current flow via electrons. The electrode includes a second portion to apply a current to a nerve tissue. The second portion carries current flow via ions. The second portion is positioned between the nerve tissue and the first portion to prevent the first portion from touching the nerve tissue. The current applied to the nerve tissue is produced in the second portion in response to a current that is present in the first portion. The current present in the first portion is provided from a single phase current source. The electrode may be used in applications including, but not limited to, nerve block applications and nerve stimulation applications.
摘要翻译： 示例性的离子耦合电极被描述。 一个示例性的离子导电电极包括可以耦合到单相电流源的第一部分。 第一部分通过电子传送电流。 电极包括将电流施加到神经组织的第二部分。 第二部分通过离子传送电流。 第二部分位于神经组织和第一部分之间，以防止第一部分接触神经组织。 响应于存在于第一部分中的电流，在第二部分中产生施加到神经组织的电流。 第一部分中存在的电流由单相电流源提供。 电极可用于包括但不限于神经阻滞应用和神经刺激应用的应用中。
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公开(公告)号：US20110125216A1
公开(公告)日：2011-05-26
申请号：US12948848
申请日：2010-11-18
IPC分类号： A61N1/18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/36185
摘要： Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode also includes a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.
摘要翻译： 描述可调电极示例。 一个示例性可调节电极包括两个或更多个触点，其被配置为以足以在神经中产生HFAC神经传导阻滞的量向神经选择性地递送高频交流电（HFAC）。 示例性可调电极还包括被配置为选择性地控制两个或多个触点中的哪一个将HFAC递送到神经以控制神经电极是否处于第一（例如起始应答缓解）配置或第二（例如，HFAC） 神经传导阻滞维持）配置。 电极可用于包括但不限于神经阻滞应用和神经刺激应用的应用中。 可以通过改变属性来调节电极，包括但不限于数量，长度，取向，距离，表面积以及与用于递送HFAC的接触的神经的距离。
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