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公开(公告)号:US08440706B2
公开(公告)日:2013-05-14
申请号:US13036930
申请日:2011-02-28
申请人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号: A61K31/424 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/502 , A61K31/437 , A61K31/497
CPC分类号: C07D498/10 , A61K38/00 , C07D498/20 , C07D519/00 , C07K5/06026 , C07K5/06191 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0827
摘要: The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.
摘要翻译: 本发明涉及抑制丝氨酸蛋白酶活性,特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。
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公开(公告)号:US20110165120A1
公开(公告)日:2011-07-07
申请号:US13036930
申请日:2011-02-28
申请人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号: A61K38/21 , C07D498/10 , A61K31/424 , C07D498/20 , C07D413/14 , A61K31/4709 , C07D401/14 , A61K31/4439 , A61K31/497 , A61K31/454 , A61K31/437 , A61K31/5377 , A61K31/502 , A61K31/397 , A61K38/22 , A61K31/7056 , A61K31/7072 , A61K38/45 , A61K38/46 , A61P31/12 , A01N43/80 , A01N43/42 , A01N43/40 , A01N43/58 , A01N43/84 , A01P1/00 , C12N9/99 , C12N7/06
CPC分类号: C07D498/10 , A61K38/00 , C07D498/20 , C07D519/00 , C07K5/06026 , C07K5/06191 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0827
摘要: The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.
摘要翻译: 本发明涉及抑制丝氨酸蛋白酶活性,特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。
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公开(公告)号:US07985762B2
公开(公告)日:2011-07-26
申请号:US11511109
申请日:2006-08-28
申请人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号: C07D209/54 , C07D401/14 , C07D413/14 , C07D237/30 , A61K31/424 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/502 , A61K31/437 , A61K31/497
CPC分类号: C07D498/10 , A61K38/00 , C07D498/20 , C07D519/00 , C07K5/06026 , C07K5/06191 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0827
摘要: The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3—NS4A protease.
摘要翻译: 本发明涉及抑制丝氨酸蛋白酶活性,特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。
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公开(公告)号:US08372873B2
公开(公告)日:2013-02-12
申请号:US13074772
申请日:2011-03-29
申请人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号: A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4725
CPC分类号: C07D498/10
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐。 这些化合物抑制丝氨酸蛋白酶,特别是丙型肝炎病毒NS3-NS4A蛋白酶。
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公开(公告)号:US07964624B1
公开(公告)日:2011-06-21
申请号:US11711845
申请日:2007-02-27
申请人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人: Kevin M. Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号: A61K31/42 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4725 , C07D498/10 , C07D261/04 , C07D413/04
CPC分类号: C07D498/10
摘要: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐。 这些化合物抑制丝氨酸蛋白酶,特别是丙型肝炎病毒NS3-NS4A蛋白酶。
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公开(公告)号:US20070179167A1
公开(公告)日:2007-08-02
申请号:US11511109
申请日:2006-08-28
申请人: Kevin Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
发明人: Kevin Cottrell , John Maxwell , Qing Tang , Anne-Laure Grillot , Arnaud Le Tiran , Emanuele Perola
IPC分类号: A61K31/4747 , A61K31/42 , C07D491/10
CPC分类号: C07D498/10 , A61K38/00 , C07D498/20 , C07D519/00 , C07K5/06026 , C07K5/06191 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0827
摘要: The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.
摘要翻译: 本发明涉及抑制丝氨酸蛋白酶活性,特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。
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公开(公告)号:US08404852B2
公开(公告)日:2013-03-26
申请号:US13234634
申请日:2011-09-16
申请人: Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人: Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven M. Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号: A61K31/4439 , C07D401/04
CPC分类号: C07D413/14 , A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
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公开(公告)号:US20090176771A1
公开(公告)日:2009-07-09
申请号:US12246778
申请日:2008-10-07
申请人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号: A61K31/55 , C07D243/12 , A61P31/04
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译: 本发明涉及抑制细菌促旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此,本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号:US20090325955A1
公开(公告)日:2009-12-31
申请号:US12483312
申请日:2009-06-12
申请人: PAUL Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人: PAUL Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号: A61K31/506 , A61K31/5377 , A61P31/04 , A61K31/519 , A61K31/4439 , A61K31/4184
CPC分类号: A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译: 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗,预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
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公开(公告)号:US20130023525A1
公开(公告)日:2013-01-24
申请号:US13454510
申请日:2012-04-24
申请人: Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人: Paul S. Charifson , David D. Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号: A61K31/4184 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D405/14 , A61P31/04 , A61K31/4545 , C07D491/056 , A61K31/4355 , C07D413/14 , A61K31/5377 , A61K31/5513 , C07D403/14 , C07D403/10
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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