公开(公告)号：US20110172238A1

公开(公告)日：2011-07-14

申请号：US12838350

申请日：2010-07-16

申请人： James A. Henderson ,  John Maxwell ,  Louis Vaillancourt ,  Mark Morris ,  Ronald Grey, JR. ,  Simon Giroux ,  Laval Chan Chun Kong ,  Sanjoy Kumar Das ,  Bingcan Liu ,  Carl Poisson ,  Caroline Cadilhac ,  Monica Bubenik ,  T. Jagadeeswar Reddy ,  Guy Falardeau ,  Constantin Yannopoulos ,  Jian Wang ,  Oswy Z. Pereira ,  Youssef L. Bennani ,  Albert C. Pierce ,  Govinda Rao Bhisetti ,  Kevin M. Cottrell ,  Valerie Marone

发明人： James A. Henderson ,  John Maxwell ,  Louis Vaillancourt ,  Mark Morris ,  Ronald Grey, JR. ,  Simon Giroux ,  Laval Chan Chun Kong ,  Sanjoy Kumar Das ,  Bingcan Liu ,  Carl Poisson ,  Caroline Cadilhac ,  Monica Bubenik ,  T. Jagadeeswar Reddy ,  Guy Falardeau ,  Constantin Yannopoulos ,  Jian Wang ,  Oswy Z. Pereira ,  Youssef L. Bennani ,  Albert C. Pierce ,  Govinda Rao Bhisetti ,  Kevin M. Cottrell ,  Valerie Marone

IPC分类号： A61K31/496 ,  C07D403/14 ,  A61K31/4184 ,  C07D401/14 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/4439 ,  A61P31/14

CPC分类号： C07K5/06052 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

摘要： Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

摘要翻译： 其中A，B，B'，X，Y，R1，R1'，R2，R2'，R3，R3'，R5，R5'，R6，m， n或p如本文所定义，可用于治疗黄病毒科病毒感染。

公开(公告)号：US20110165120A1

公开(公告)日：2011-07-07

申请号：US13036930

申请日：2011-02-28

申请人： Kevin M. Cottrell ,  John Maxwell ,  Qing Tang ,  Anne-Laure Grillot ,  Arnaud Le Tiran ,  Emanuele Perola

发明人： Kevin M. Cottrell ,  John Maxwell ,  Qing Tang ,  Anne-Laure Grillot ,  Arnaud Le Tiran ,  Emanuele Perola

IPC分类号： A61K38/21 ,  C07D498/10 ,  A61K31/424 ,  C07D498/20 ,  C07D413/14 ,  A61K31/4709 ,  C07D401/14 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/454 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/502 ,  A61K31/397 ,  A61K38/22 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/45 ,  A61K38/46 ,  A61P31/12 ,  A01N43/80 ,  A01N43/42 ,  A01N43/40 ,  A01N43/58 ,  A01N43/84 ,  A01P1/00 ,  C12N9/99 ,  C12N7/06

CPC分类号： C07D498/10 ,  A61K38/00 ,  C07D498/20 ,  C07D519/00 ,  C07K5/06026 ,  C07K5/06191 ,  C07K5/0804 ,  C07K5/0808 ,  C07K5/081 ,  C07K5/0827

摘要： The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.

摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。

公开(公告)号：US07906550B2

公开(公告)日：2011-03-15

申请号：US12026705

申请日：2008-02-06

申请人： Kevin M. Cottrell ,  John Maxwell ,  Robert B. Perni ,  Janos Pitlik

发明人： Kevin M. Cottrell ,  John Maxwell ,  Robert B. Perni ,  Janos Pitlik

IPC分类号： A61K31/4025 ,  C07D207/30

CPC分类号： C07K5/0804 ,  A61K31/40 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.

摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，并且作为抗病毒剂是有用的。 本发明还涉及包含用于离体使用或用于给予HCV感染患者的所述化合物的药学上可接受的组合物以及制备该化合物的方法。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗患者HCV感染的方法。

公开(公告)号：US07028086B2

公开(公告)日：2006-04-11

申请号：US09934984

申请日：2001-08-22

申请人： David John Maxwell ,  Paul Sandie ,  Jonathan G. G. Tams ,  Stephen Kitt ,  Neil E Harrison

发明人： David John Maxwell ,  Paul Sandie ,  Jonathan G. G. Tams ,  Stephen Kitt ,  Neil E Harrison

IPC分类号： G06F15/173

CPC分类号： H04L41/0213 ,  H04L41/12

摘要： Ingress to egress network traffic ratios are determined for at least some devices within a network and server-like devices are selected on the basis of the determined ratios or a figure derived from the determined ratios. Selecting the server-like devices includes the step of selecting those devices having a value of ratio above a selected value and includes ranking the devices in order of their ratios and determining discontinuities in the values of the ratios of the ranked devices. The server-like devices are connected to a port of another device and the ingress to egress network traffic ratio is determined by determining the network traffic through the port using SNMP.

摘要翻译： 针对网络中的至少一些设备确定入口到出口网络流量比率，并且基于确定的比率或从所确定的比率导出的图形来选择类似服务器的设备。 选择类似服务器的设备包括选择具有高于所选值的比值的设备的步骤，并且包括按照它们的比例的顺序对设备进行排序，并且确定排名设备的比率的值的不连续性。 类似服务器的设备连接到另一设备的端口，通过使用SNMP确定通过端口的网络流量来确定入口到出口网络流量比。

公开(公告)号：US20050137855A1

公开(公告)日：2005-06-23

申请号：US10739349

申请日：2003-12-19

申请人： John Maxwell

发明人： John Maxwell

IPC分类号： G06F17/27 ,  G06F17/28

CPC分类号： G06F17/2881

摘要： Techniques are provided to generate alternate phrases from a packed meaning representation. The semantics of input items in a packed meaning representation are matched against a lexicon to determine initial entries in a phrasal information structure. Context, syntax and semantic information describing each phrasal entry are added to the phrasal information structure. Linear or other implications are used to determine a set of unordered rewrite rules. The unordered rewrite rules associate semantic information with pseudofacts such that a complete set of choices from the set of disjunctions in the packed meaning representation is selected. Semantic information associated with the unordered rewrite rules identifies entries in the phrasal information structure to be updated with the pseudofact of the unordered rewrite rule; Entries in the phrasal information structure not associated with false contexts are combined based on ordered rewrite rules. The ordered rewrite rules are based on the language of the packed meaning representation. Source information associated with each new entry in the phrasal information structure reflects the phrasal entry identifiers of the entries used to determine the new entry. For any set of entries in the phrasal information structure produced by an ordered rewrite rule, the context of a missing semantic fact is subtracted from the context of the entry lacking the semantic fact. Entries associated with a false context are discarded and entries sharing the same syntax and semantic information are merged. Any entries in the phrasal information structure associated with the “ALL” pseudofact are then determined. Alternate phrases are generated based on the source information for the entry in the phrasal information structure associated with the “ALL” pseudofact.

摘要翻译： 提供技术以从打包的意义表示生成替代短语。 打包意义表示中的输入项的语义与词典匹配以确定短语信息结构中的初始条目。 描述每个短语条目的上下文，语法和语义信息被添加到短语信息结构中。 线性或其他含义用于确定一组无序重写规则。 无序重写规则将语义信息与伪文本相关联，使得选择来自包装含义表示中的一组分离的完整的选择集合。 与无序重写规则相关联的语义信息识别要用无序重写规则的伪指令更新的短语信息结构中的条目; 基于有序重写规则组合了与虚假上下文无关的短语信息结构中的条目。 有序重写规则基于打包意义表示的语言。 与短语信息结构中的每个新条目相关联的源信息反映用于确定新条目的条目的短语条目标识符。 对于由有序重写规则产生的短语信息结构中的任何一组条目，从缺少语义事实的条目的上下文中减去缺失语义事实的上下文。 与false上下文关联的条目被丢弃，并且共享相同语法和语义信息的条目被合并。 然后确定与“ALL”pseudofact相关联的短语信息结构中的任何条目。 基于与“ALL”假结构相关联的短语信息结构中的条目的源信息生成替代短语。

公开(公告)号：US20050052849A1

公开(公告)日：2005-03-10

申请号：US10715907

申请日：2003-11-18

申请人： David Keating ,  Antoin Russell ,  Mysore Divakar ,  Thomas Templeton ,  John Maxwell

发明人： David Keating ,  Antoin Russell ,  Mysore Divakar ,  Thomas Templeton ,  John Maxwell

IPC分类号： H01R20060101 ,  H01R43/02 ,  H05K7/20

CPC分类号： H01R12/52 ,  H01R12/57 ,  H01R12/7064 ,  H01R43/0263

摘要： The invention provides arrangements to facilitate surface mounting of subassembly boards on a motherboard with reliable, high conductivity interconnection. In accordance with the invention, the subassembly interconnection arrangement is composed of separate power and sense connector arms formed on one or more base headers. The arrangement interconnects and supports the subassembly board on the motherboard surface. Each power arm advantageously comprises a plurality of split-based mounting lugs secured to the arm in a coplanar configuration. Each sense connector arm preferably comprises a plurality of connector pins secured to the arm in a coplanar configuration. Embodiments are disclosed for vertical and horizontal surface mounting.

摘要翻译： 本发明提供了便于在具有可靠的高导电性互连的母板上表面安装子组件板的布置。 根据本发明，子组件互连装置由形成在一个或多个底部集管上的分开的功率和感测连接臂构成。 该布置将主组件板上的子组件板互连并支撑。 每个动力臂有利地包括以共面构造固定到臂的多个基于分组的安装凸耳。 每个感测连接器臂优选地包括以共面构造固定到臂的多个连接器销。 公开了用于垂直和水平表面安装的实施例。

公开(公告)号：US06479974B2

公开(公告)日：2002-11-12

申请号：US09750884

申请日：2000-12-28

申请人： John Maxwell Cohn ,  Alvar Antonio Dean ,  David James Hathaway ,  Patrick Edward Perry ,  Sebastian Theodore Ventrone

发明人： John Maxwell Cohn ,  Alvar Antonio Dean ,  David James Hathaway ,  Patrick Edward Perry ,  Sebastian Theodore Ventrone

IPC分类号： G05F304

CPC分类号： H01L23/5286 ,  H01L2924/0002 ,  H01L2924/00

摘要： A system and method for providing on-chip voltage distribution and regulation. In accordance with the system of the present invention, an IC chip includes a source voltage plane having a source supply rail for supplying power to the IC chip and a source ground rail for sinking power supplied therefrom. At least one intermediate ground rail is connected between the source supply rail and the source ground rail to divide the source voltage plane into multiple intermediate voltage planes. The intermediate ground rail serves as a supply rail for a subsequent intermediate voltage plane such that the intermediate voltage planes are series-connected.

摘要翻译： 一种用于提供片上电压分配和调节的系统和方法。 根据本发明的系统，IC芯片包括具有用于向IC芯片供电的源极电源轨的源极电压平面和用于从其供电的电力的源极接地导轨。 至少一个中间接地轨连接在源电源轨和源极接地轨之间，以将源电压平面分成多个中间电压平面。 中间接地导轨用作后续中间电压平面的电源轨，使得中间电压平面串联连接。

公开(公告)号：US5581780A

公开(公告)日：1996-12-03

申请号：US451094

申请日：1995-05-25

申请人： Ronald M. Kaplan ,  Martin Kay ,  John Maxwell

发明人： Ronald M. Kaplan ,  Martin Kay ,  John Maxwell

IPC分类号： G06F17/30 ,  G06F9/00

CPC分类号： G06F17/30985 ,  Y10S707/99936

摘要： An FSM data structure is encoded by generating a transition unit of data corresponding to each transition which leads ultimately to a final state of the FSM. Information about the states is included in the transition units, so that the encoded data structure can be written without state units of data. The incoming transition units to a final state each contain an indication of finality. The incoming transition units to a state which has no outgoing transition units each contain a branch ending indication. The outgoing transition units of each state are ordered into a comparison sequence for comparison with a received element, and all but the last outgoing transition unit contain an alternative indication of a subsequent alternative outgoing transition. The indications are incorporated with the label of each transition unit into a single byte, and the remaining byte values are allocated among a number of pointer data units, some of which begin full length pointers and some of which begin pointer indexes to tables where pointers are entered. The pointers may be used where a state has a large number of incoming transitions or where the block of transition units depending from a state is broken down to speed access. The first outgoing transition unit of a state is positioned immediately after one of the incoming transitions so that it may be found without a pointer. Each alternative outgoing transition unit is stored immediately after the block beginning with the previous outgoing transition unit so that it may be found by proceeding through the transition units until the number of alternative bits and the number of branch ending bits balance.

摘要翻译： FSM数据结构通过产生对应于每个转换的数据的转移单元进行编码，这导致最终导致FSM的最终状态。 关于状态的信息被包括在转换单元中，使得编码的数据结构可以被写入而没有状态单元的数据。 到最终状态的进入转换单元都包含最终性的指示。 进入转移单元到没有输出转移单元的状态，每个都包含分支结束指示。 每个状态的输出转换单元被排序成比较序列，以便与接收到的元件进行比较，除了最后一个输出转换单元之外，除了最后一个输出转换单元之外的所有替代指示还包括随后的替代输出转换。 指示与每个转换单元的标签并入单个字节，并且其余字节值分配在多个指针数据单元中，其中一些指针数据单元开始全长指针，其中一些指针开始指向指针的表的指针索引 输入 指针可以用于状态具有大量进入转换的地方，或者来自状态的过渡单位块被分解以加速访问。 一个状态的第一个输出转换单元位于一个输入转换之后，从而可以在没有指针的情况下找到它。 每个替代的输出转换单元紧紧地存储在从先前的输出转换单元开始的块之后，以便可以通过进行转换单元找到直到替代位的数目和分支结束位的数目平衡为止。

公开(公告)号：US4044667A

公开(公告)日：1977-08-30

申请号：US549819

申请日：1975-02-13

申请人： John Maxwell Jackson

发明人： John Maxwell Jackson

IPC分类号： B41F17/14 ,  B41F17/22 ,  B41F17/28

CPC分类号： B41F17/28 ,  B41F17/22

摘要： A machine for printing on thin-walled frusto-conical containers having little resistance to transverse deformation is provided with rotatable mandrels for holding and centering the containers during printing. Each mandrel has a rotatable body provided with two axially spaced centering rings adapted to engage the walls of the container and centralize the container relative to the axis of the mandrel upon axial movement of the container on to the mandrel. The centering rings make sealing engagement with the walls of the container and subdivide the space enclosed between the container and the mandrel body into an end chamber between the base of the container and the outer end of the mandrel, and an annular chamber between the side wall of the container and the mandrel body. The mandrel body is provided with suction conduit means for extracting air from the end chamber so as to hold the container on the mandrel with the centering rings in sealing engagement with the container walls, and the mandrel body is also provided with pressure conduit means for supplying compressed air to the annular chamber to support the side wall of the container against transverse deformation during a printing operation.

摘要翻译： 在对横向变形几乎没有阻力的薄壁截头圆锥形容器上进行打印的机器设置有用于在打印期间保持和定心容器的可旋转心轴。 每个心轴具有一个可转动的主体，该主体设置有两个轴向间隔开的定心环，其适于与容器的壁接合，并且在将容器轴向移动到心轴上时相对于心轴的轴线集中。 定心环与容器的壁密封接合，并将容器和心轴本体之间封闭的空间细分成容器的底部和心轴的外端之间的端室，并且在侧壁 的容器和心轴体。 心轴体设置有用于从端室抽取空气的吸入管道装置，以便将容器保持在心轴上，使定心环与容器壁密封接合，心轴本体还设置有用于供应的压力导管装置 压缩空气到环形室以在打印操作期间支撑容器的侧壁以防横向变形。

公开(公告)号：US3984791A

公开(公告)日：1976-10-05

申请号：US589852

申请日：1975-06-24

申请人： John Maxwell Deacon

发明人： John Maxwell Deacon

IPC分类号： H03H3/08 ,  H03H9/00 ,  H03H9/02 ,  H03H9/145 ,  H03H9/04 ,  H03H9/30

CPC分类号： H03H9/14552 ,  H03H9/0285 ,  Y10T29/42

摘要： An acoustic surface wave filter which includes a strip member of a piezoelectric material having input and output interdigital transducers formed on a major surface thereof, each of the interdigital transducers including two interlaced rows of parallel spaced-apart elongated members, each of the elongated members of at least one of the rows being bifurcated to provide two parallel limbs, the limbs of each of the bifurcated members being connected together by means of at least one connecting link.

摘要翻译： 声表面波滤波器，其包括压电材料的带状构件，其具有形成在其主表面上的输入和输出叉指换能器，每个叉指换能器包括两个隔行的平行隔开的细长构件，每个细长构件 至少一列被分叉以提供两个平行的四肢，每个分叉构件的四肢通过至少一个连接杆连接在一起。