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公开(公告)号：US06423500B1
公开(公告)日：2002-07-23
申请号：US09439672
申请日：1999-11-15
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , Bazan Fernando J. , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , Bazan Fernando J. , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N3353
CPC分类号： C07K14/7155 , A61K38/00 , C07K14/5428 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
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公开(公告)号：US5985828A
公开(公告)日：1999-11-16
申请号：US472097
申请日：1995-06-07
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , A61K38/16
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
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公开(公告)号：US5789192A
公开(公告)日：1998-08-04
申请号：US110683
申请日：1993-08-23
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
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4.发明授权Antibodies which specifically bind mammalian receptors for interleukin-10 (IL-10) 失效特异性结合哺乳动物受体的白细胞介素-10（IL-10）
公开(公告)号：US5863796A
公开(公告)日：1999-01-26
申请号：US477166
申请日：1995-06-07
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , C07K16/28 , C12N5/12 , G01N33/53
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
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5.发明授权公开(公告)号：US08282914B2
公开(公告)日：2012-10-09
申请号：US13098641
申请日：2011-05-02
申请人： Chuan-Chu Chou , Loretta A. Bober , Lee Sullivan
发明人： Chuan-Chu Chou , Loretta A. Bober , Lee Sullivan
IPC分类号： A61K38/19
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/30 , C07K2319/75
摘要： The present invention provides polypeptides including MCP1 fused, optionally, by a linker, to an immunoglobulin. Methods for using the polypeptides to treat medical disorders are also covered.
摘要翻译： 本发明提供了多肽，其包括任选地通过接头与免疫球蛋白融合的MCP1。 也涵盖了使用多肽治疗医学疾病的方法。
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公开(公告)号：US20110280873A1
公开(公告)日：2011-11-17
申请号：US13105453
申请日：2011-05-11
申请人： Leonard G. Presta , Chuan-Chu Chou
发明人： Leonard G. Presta , Chuan-Chu Chou
IPC分类号： A61K39/395 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C07K19/00 , C12P21/02 , C07H21/04 , A61P3/10 , A61P35/00 , A61P9/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P19/06 , A61P19/02 , A61P7/00 , A61P11/06 , A61P29/00 , A61P37/08 , A61P9/10 , A61P11/00 , A61P25/00 , A61P3/02 , C12N15/63
CPC分类号： C07K14/4713 , C07K14/70596 , C07K2319/30
摘要： The present invention provides, in part, MCP1-Ig fusion polypeptides exhibiting surprisingly beneficial properties as well as methods for treating various diseases (e.g., inflammatory diseases) by administering any of such fusions.
摘要翻译： 本发明部分地提供了表现出惊人的有益性质的MCP1-Ig融合多肽以及通过施用任何这种融合物来治疗各种疾病（例如炎性疾病）的方法。
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公开(公告)号：US20070036750A1
公开(公告)日：2007-02-15
申请号：US11502064
申请日：2006-08-10
申请人： Chuan-Chu Chou , Loretta Bober , Lee Sullivan
发明人： Chuan-Chu Chou , Loretta Bober , Lee Sullivan
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/30 , C07K2319/75
摘要： The present invention provides polypeptides including MCP1 fused, optionally, by a linker, to an immunoglobulin. Methods for using the polypeptides to treat medical disorders are also covered.
摘要翻译： 本发明提供了多肽，其包括任选地通过接头与免疫球蛋白融合的MCP1。 也涵盖了使用多肽治疗医学疾病的方法。
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公开(公告)号：US6056957A
公开(公告)日：2000-05-02
申请号：US284516
申请日：1994-08-04
申请人： Chuan-Chu Chou , Nicholas J. Murgolo , John S. Abrams , Chung-Her Jenh , Mary E. Petro , Jon E. Silver , Stephen Tindall , William T. Windsor , Paul J. Zavodny
发明人： Chuan-Chu Chou , Nicholas J. Murgolo , John S. Abrams , Chung-Her Jenh , Mary E. Petro , Jon E. Silver , Stephen Tindall , William T. Windsor , Paul J. Zavodny
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24
摘要： A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.
摘要翻译： 提供特异性结合人白介素-5的单克隆抗体。 还提供了产生单克隆抗体的杂交瘤; 编码单克隆抗体的重链和轻链可变区及其CDR的互补DNA; 人源化单克隆抗体; 以及包含针对其的单克隆抗体或抗独特型抗体的药物组合物，人源化单克隆抗体，结合片段，结合组合物或衍生自抗体的单链结合蛋白和生理上可接受的载体。
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公开(公告)号：US08524217B2
公开(公告)日：2013-09-03
申请号：US13105453
申请日：2011-05-11
申请人： Leonard G. Presta , Chuan-Chu Chou
发明人： Leonard G. Presta , Chuan-Chu Chou
CPC分类号： C07K14/4713 , C07K14/70596 , C07K2319/30
摘要： The present invention provides, in part, MCP1-Ig fusion polypeptides exhibiting surprisingly beneficial properties as well as methods for treating various diseases (e.g., inflammatory diseases) by administering any of such fusions.
摘要翻译： 本发明部分地提供了表现出惊人的有益性质的MCP1-Ig融合多肽以及通过施用任何这种融合物来治疗各种疾病（例如炎性疾病）的方法。
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公开(公告)号：US20110206669A1
公开(公告)日：2011-08-25
申请号：US13098641
申请日：2011-05-02
申请人： Chuan-Chu Chou , Loretta A. Bober , Lee Sullivan
发明人： Chuan-Chu Chou , Loretta A. Bober , Lee Sullivan
IPC分类号： A61K39/395 , A61P29/00 , A61P17/06 , A61P1/04 , A61P1/00 , A61P31/12 , A61P11/06 , A61P37/08 , A61P11/08 , A61P15/00 , A61P17/02 , A61P17/12 , A61P19/02 , A61P25/00 , A61M37/00
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/30 , C07K2319/75
摘要： The present invention provides polypeptides including MCP1 fused, optionally, by a linker, to an immunoglobulin. Methods for using the polypeptides to treat medical disorders are also covered.
摘要翻译： 本发明提供了多肽，其包括任选地通过接头与免疫球蛋白融合的MCP1。 也涵盖了使用多肽治疗医学疾病的方法。
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