公开(公告)号：US09750426B2

公开(公告)日：2017-09-05

申请号：US13301300

申请日：2011-11-21

申请人： Kiaran P McGee ,  Richard L Ehman ,  Stephen M Ansell ,  Yogesh K Mariappan ,  Jun Chen

发明人： Kiaran P McGee ,  Richard L Ehman ,  Stephen M Ansell ,  Yogesh K Mariappan ,  Jun Chen

IPC分类号： A61B5/055 ,  A61B5/00

CPC分类号： A61B5/055 ,  A61B5/0051

摘要： A system and method for determining a response of a tumor following a chemotherapy process includes the use of a magnetic resonance elastography (MRE) driver and a magnetic resonance imaging (MRI) system. The method includes controlling the MRE driver and the MRI system to acquire raw MRE data from the tumor, inverting the raw MRE data to produce an elastogram of the tumor, and determining a response of the tumor to the chemotherapy process from the elastogram.

公开(公告)号：US08952693B2

公开(公告)日：2015-02-10

申请号：US13453653

申请日：2012-04-23

申请人： David S Lake ,  Kiaran P McGee ,  Armando Manduca ,  Yogesh K Mariappan ,  Richard L Ehman

发明人： David S Lake ,  Kiaran P McGee ,  Armando Manduca ,  Yogesh K Mariappan ,  Richard L Ehman

IPC分类号： G01R33/563

CPC分类号： G01R33/56358

摘要： A method for calculating a mechanical property of a material using a magnetic resonance imaging (“MRI”) system is provided. The method is particularly robust to image data having low signal-to-noise ratio (“SNR”). An MRI system is used to acquire magnetic resonance elastography (“MRE”) data from a subject containing the material. Exemplary materials include lung tissue. Images are reconstructed from the MRE data and used to produce a wave image from which a spatial frequency spectrum is produced. A principal frequency of the spatial frequency spectrum is produced and used to calculate a mechanical property of the material. For example, shear stiffness may be calculated.

摘要翻译： 提供了使用磁共振成像（“MRI”）系统计算材料的机械特性的方法。 该方法对具有低信噪比（“SNR”）的图像数据特别鲁棒​​。 MRI系统用于从包含材料的受试者获取磁共振弹性成像（“MRE”）数据。 示例性材料包括肺组织。 从MRE数据重建图像，并用于产生从其产生空间频谱的波形图像。 产生空间频谱的主频率并用于计算材料的机械性能。 例如，可以计算剪切刚度。

公开(公告)号：US08508229B2

公开(公告)日：2013-08-13

申请号：US12847712

申请日：2010-07-30

申请人： Eric C Ehman ,  Kiaran P McGee ,  Richard L Ehman

发明人： Eric C Ehman ,  Kiaran P McGee ,  Richard L Ehman

IPC分类号： G01R33/565

CPC分类号： G01R33/56358

摘要： A magnetic resonance elastography (“MRE”) driver that can produce shear waves in a subject without relying on mode conversion of longitudinal waves is disclosed. More specifically, the MRE driver includes a pneumatic driver located remotely from a magnetic resonance imaging (“MRI”) system which is operable in response to an applied electrical current to oscillate, a pressure-activated driver that is positioned on a subject in the MRI system, and a tube that is in fluid communication, at one end, with the pneumatic driver. The pressure-activated driver includes a base plate and a driver plate having a region between them that receives the tube. Oscillations of the pneumatic driver produce a pressure wave in the tube that causes the driver plate to vibrate. The driver plate rests against the subject of interest to apply a corresponding shear oscillatory force to the subject during the MRE examination.

摘要翻译： 公开了一种能够在不依赖纵波的模式转换的情况下在受试者中产生剪切波的磁共振弹性成像（“MRE”）驱动器。 更具体地说，MRE驱动器包括一个位于远离磁共振成像（“MRI”）系统的气动驱动器，该系统可响应所施加的电流振荡而操作，压力激活的驱动器位于MRI中的受试者身上 系统和一个管，其一端与气动驱动器流体连通。 压力驱动的驱动器包括基板和驱动板，驱动板在它们之间具有容纳管的区域。 气动驱动器的振动在管中产生压力波，导致驱动器板振动。 驾驶员座椅抵靠感兴趣的主题，以在MRE检查期间向对象施加相应的剪切振荡力。

公开(公告)号：US08615285B2

公开(公告)日：2013-12-24

申请号：US12418204

申请日：2009-04-03

申请人： Richard L Ehman ,  Phillip J. Rossman ,  Jun Chen

发明人： Richard L Ehman ,  Phillip J. Rossman ,  Jun Chen

IPC分类号： A61B5/05

CPC分类号： G01R33/56358 ,  A61B5/0051 ,  A61B5/055 ,  A61B8/4236 ,  A61B8/485 ,  G01R33/28 ,  G01R33/4814

摘要： An acoustic driver system for use in applying an oscillating stress to a subject undergoing a magnetic resonance elastography (MRE) examination includes a flexible passive driver located in the bore of the magnet and in contact with the subject. A remotely located active driver is acoustically coupled to the passive driver and produces acoustic energy in response to an applied current. The passive driver produces shear waves in response to the acoustic energy and are directed into the body of the subject undergoing the MRE examination.

摘要翻译： 用于向经历磁共振弹性成像（MRE）检查的对象施加振荡应力的声学驱动器系统包括位于磁体的孔中并与对象接触的柔性被动驱动器。 远程定位的有源驱动器与无源驱动器声学耦合，并响应于所施加的电流产生声能。 被动驱动器响应于声能产生剪切波，并被引导到经历MRE检查的对象的身体中。

公开(公告)号：US08971602B2

公开(公告)日：2015-03-03

申请号：US13453646

申请日：2012-04-23

申请人： Kevin J Glaser ,  Richard L Ehman ,  David A Olsen

发明人： Kevin J Glaser ,  Richard L Ehman ,  David A Olsen

IPC分类号： G06K9/00 ,  G01R33/563 ,  A61B5/055 ,  A61B5/00

CPC分类号： G01R33/56358 ,  A61B5/055 ,  A61B5/4244 ,  A61B5/7292

摘要： A dynamic magnetic resonance elastography (“MRE”) method for quantifying liver stiffness using intrinsic transient waveforms imparted on the liver by the beating heart is provided. The method includes synchronizing motion-encoding gradients in an MRE pulse sequence to the subject's cardiac cycle.

摘要翻译： 提供了一种动态磁共振弹性成像（“MRE”）方法，用于通过跳动心脏在肝脏上施加的内在瞬态波形来定量肝硬度。 该方法包括将MRE脉冲序列中的运动编码梯度与受试者的心动周期同步。