公开(公告)号：US08971602B2

公开(公告)日：2015-03-03

申请号：US13453646

申请日：2012-04-23

申请人： Kevin J Glaser ,  Richard L Ehman ,  David A Olsen

发明人： Kevin J Glaser ,  Richard L Ehman ,  David A Olsen

IPC分类号： G06K9/00 ,  G01R33/563 ,  A61B5/055 ,  A61B5/00

CPC分类号： G01R33/56358 ,  A61B5/055 ,  A61B5/4244 ,  A61B5/7292

摘要： A dynamic magnetic resonance elastography (“MRE”) method for quantifying liver stiffness using intrinsic transient waveforms imparted on the liver by the beating heart is provided. The method includes synchronizing motion-encoding gradients in an MRE pulse sequence to the subject's cardiac cycle.

摘要翻译： 提供了一种动态磁共振弹性成像（“MRE”）方法，用于通过跳动心脏在肝脏上施加的内在瞬态波形来定量肝硬度。 该方法包括将MRE脉冲序列中的运动编码梯度与受试者的心动周期同步。

公开(公告)号：US20120269415A1

公开(公告)日：2012-10-25

申请号：US13453646

申请日：2012-04-23

申请人： Kevin J. Glaser ,  Richard L. Ehman ,  David A. Olsen

发明人： Kevin J. Glaser ,  Richard L. Ehman ,  David A. Olsen

IPC分类号： G06K9/36

CPC分类号： G01R33/56358 ,  A61B5/055 ,  A61B5/4244 ,  A61B5/7292

摘要： A dynamic magnetic resonance elastography (“MRE”) method for quantifying liver stiffness using intrinsic transient waveforms imparted on the liver by the beating heart is provided. The method includes synchronizing motion-encoding gradients in an MRE pulse sequence to the subject's cardiac cycle.

摘要翻译： 提供了一种动态磁共振弹性成像（MRE）方法，用于通过跳动心脏在肝脏上施加的内在瞬态波形来定量肝硬度。 该方法包括将MRE脉冲序列中的运动编码梯度与受试者的心动周期同步。

公开(公告)号：US20140114177A1

公开(公告)日：2014-04-24

申请号：US14112324

申请日：2012-04-17

申请人： Jun Chen ,  Kevin J. Glaser ,  Richard L. Ehman ,  Jennifer L. Kugel

发明人： Jun Chen ,  Kevin J. Glaser ,  Richard L. Ehman ,  Jennifer L. Kugel

IPC分类号： G01R33/563 ,  A61B5/055

CPC分类号： A61B5/0555 ,  A61B5/0051 ,  A61B5/055 ,  A61B5/4312 ,  G01R33/56358

摘要： A system and method for performing magnetic resonance elastography (MRE] of a patient's breasts is provided. An MRE driver configured to be placed on the sternum of the patient is used to impart mechanical energy to the sternum, which in turn generates shear waves in at least one of the patient's breasts. Such a driver is amenable to use with standard breast radio frequency (RF] coils without the need for modification of the existing breast RF coil hardware.

摘要翻译： 提供了一种用于执行患者乳房的磁共振弹性成像（MRE）的系统和方法，被配置为放置在患者胸骨上的MRE驱动器用于向胸骨施加机械能，这又产生剪切波 至少一个患者的乳房，这样的司机适合与标准的乳房射频（RF）线圈一起使用，而不需要修改现有的乳房RF线圈硬件。

公开(公告)号：US08072216B2

公开(公告)日：2011-12-06

申请号：US12418218

申请日：2009-04-03

申请人： Richard L. Ehman ,  Meng Yin ,  Kevin J. Glaser

发明人： Richard L. Ehman ,  Meng Yin ,  Kevin J. Glaser

IPC分类号： G01V3/00

CPC分类号： G01R33/56358 ,  A61B5/0051 ,  A61B5/416

摘要： A system is configured to produce a stress on a subject while performing a magnetic resonance elastography scan in a magnetic resonance imaging (MRI) system. The system includes an active driver operable to produce an energy configured for a magnetic resonance elastography (MRE) process. A passive actuator is configured to be positioned in the MRI system and to be coupled to the subject. The system includes a tube coupling the active driver to the passive actuator to deliver the energy produced by the active driver to the passive actuator, and a strap coupled to the passive actuator. The strap is configured to be disposed around the subject. The strap includes a substantially inelastic material configured to convert the energy delivered to the passive actuator from the tube into shear waves with the subject for use in the MRE process.

摘要翻译： 一种系统被配置为在磁共振成像（MRI）系统中执行磁共振弹性成像扫描时在对象上产生应力。 该系统包括可操作以产生为磁共振弹性成像（MRE）过程配置的能量的主动驱动器。 无源致动器被配置为定位在MRI系统中并且被耦合到对象。 该系统包括将有源驱动器耦合到无源致动器以将由主动驱动器产生的能量传递到无源致动器的管和耦合到被动致动器的条带。 带被配置为围绕被摄体设置。 带子包括基本上无弹性的材料，其被配置成将从管中输送到被动致动器的能量转换成与MRE过程中使用的被检体的剪切波。

公开(公告)号：US09562960B2

公开(公告)日：2017-02-07

申请号：US12935968

申请日：2009-04-03

申请人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

发明人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

IPC分类号： A61B5/055 ,  G01R33/563 ,  A61B5/00

CPC分类号： G01R33/56358 ,  A61B5/0051 ,  A61B5/416

摘要： A method for magnetic resonance elastography (“MRE”) is described, in which an MRE inversion that accounts for waves propagating in a finite, bounded media is employed. A vibratory motion is induced in a subject and MRE is performed to measure one or more components of the resulting displacement produced in the subject. This displacement data is subsequently filtered to provide a more accurate and computationally efficient method of inversion. Wave equations based on the geometry of the bounded media are then utilized to calculate the material properties of the subject. Such a method allows for the performance of MRE on tissues such as the heart, eye, bladder, and prostate with more accurate results.

摘要翻译： 描述了一种用于磁共振弹性成像（“MRE”）的方法，其中采用考虑在有限的有界介质中传播的波的MRE反演。 在受试者中诱发振动，并执行MRE以测量在受试者中产生的所得到的位移的一个或多个成分。 随后对该位移数据进行滤波以提供更精确和计算上有效的反演方法。 然后利用基于有界介质的几何形状的波动方程来计算受试者的材料性质。 这种方法允许在更精确的结果上在诸如心脏，眼睛，膀胱和前列腺的组织上表现MRE。

公开(公告)号：US20120259201A1

公开(公告)日：2012-10-11

申请号：US13435657

申请日：2012-03-30

申请人： Jun Chen ,  David A. Woodrum ,  Kevin J. Glaser ,  Richard L. Ehman ,  Phillip J. Rossman

发明人： Jun Chen ,  David A. Woodrum ,  Kevin J. Glaser ,  Richard L. Ehman ,  Phillip J. Rossman

IPC分类号： A61B5/055 ,  A61M25/08 ,  A61M25/095 ,  A61N5/067

CPC分类号： A61B5/055 ,  A61B5/0051 ,  A61B18/22 ,  A61B2018/00577 ,  G01R33/285 ,  G01R33/56358

摘要： A system and method for performing a magnetic resonance elastography (MRE) procedure using an MRI system to monitor operation of a medical device performing a medical procedure. The driver system includes a housing, a port located in the housing and connected to a driving power, and an inertial driver moved within the housing by the driving power. A passage is formed in the housing and extends from a first opening in the housing, through the inertial driver, and to a second opening in the housing. The inertial driver receives a medical device extending through the passage and engages the medical device to impart oscillatory motion thereto as the inertial driver is moved by the driving power. The imparted oscillatory motion travels along the medical device as a waveguide to deliver the oscillatory motion to tissue receiving the medical procedure to perform the MRE procedure.

摘要翻译： 一种使用MRI系统执行磁共振弹性成像（MRE）程序以监测执行医疗程序的医疗装置的操作的系统和方法。 驱动器系统包括壳体，位于壳体中并连接到驱动力的端口，以及通过驱动力在壳体内移动的惯性驾驶员。 通道形成在壳体中并且从壳体中的第一开口穿过惯性驱动器延伸到壳体中的第二开口。 惯性驾驶员接收通过通道延伸的医疗装置，并且当惯性驾驶员被驱动力移动时，该医疗装置接合医疗装置以给予振荡运动。 所施加的振荡运动沿着医疗装置作为波导传播，以将振荡运动传递到接收医疗过程的组织以执行MRE过程。

公开(公告)号：US20130131490A1

公开(公告)日：2013-05-23

申请号：US13453070

申请日：2012-04-23

申请人： John Huston, III ,  Clifford R. Jack, JR. ,  Kevin J. Glaser ,  Armando Manduca ,  Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

发明人： John Huston, III ,  Clifford R. Jack, JR. ,  Kevin J. Glaser ,  Armando Manduca ,  Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0042 ,  A61B5/0051 ,  A61B5/4088 ,  G01R33/56358

摘要： A system and method for analyzing a subject using a magnetic resonance imaging (MRI) system is provided. The technique includes positioning a subject within the MRI system and coupling a driver to the subject to impart vibrational energy to the subject. The technique further includes using the MRI system and in coordination with operation of the driver, acquiring medical imaging data from the subject's brain and deriving stiffness information of the subject's brain from the medical imaging data. A report, such as an image, can be provided indicating the stiffness information of the subject's brain relative to baseline stiffness information to indicate a status of the subject with respect to a neurodegenerative disease.

摘要翻译： 提供了一种使用磁共振成像（MRI）系统分析对象的系统和方法。 该技术包括将对象定位在MRI系统内并且将驾驶员与受试者联接以向对象施加振动能量。 该技术还包括使用MRI系统并与驾驶员的操作协调，从受试者的大脑获取医学成像数据，并从医学成像数据导出受检者脑部的刚度信息。 可以提供诸如图像的报告，指示受试者的脑相对于基线刚度信息的刚度信息，以指示受试者相对于神经变性疾病的状态。

公开(公告)号：US09173589B2

公开(公告)日：2015-11-03

申请号：US13435657

申请日：2012-03-30

申请人： Jun Chen ,  David A. Woodrum ,  Kevin J. Glaser ,  Richard L. Ehman ,  Phillip J. Rossman

发明人： Jun Chen ,  David A. Woodrum ,  Kevin J. Glaser ,  Richard L. Ehman ,  Phillip J. Rossman

IPC分类号： A61B5/05 ,  A61B5/055 ,  G01R33/28 ,  G01R33/563 ,  A61B18/22 ,  A61B18/00

CPC分类号： A61B5/055 ,  A61B5/0051 ,  A61B18/22 ,  A61B2018/00577 ,  G01R33/285 ,  G01R33/56358

摘要： A system and method for performing a magnetic resonance elastography (MRE) procedure using an MRI system to monitor operation of a medical device performing a medical procedure. The driver system includes a housing, a port located in the housing and connected to a driving power, and an inertial driver moved within the housing by the driving power. A passage is formed in the housing and extends from a first opening in the housing, through the inertial driver, and to a second opening in the housing. The inertial driver receives a medical device extending through the passage and engages the medical device to impart oscillatory motion thereto as the inertial driver is moved by the driving power. The imparted oscillatory motion travels along the medical device as a waveguide to deliver the oscillatory motion to tissue receiving the medical procedure to perform the MRE procedure.

摘要翻译： 一种使用MRI系统执行磁共振弹性成像（MRE）程序以监测执行医疗程序的医疗装置的操作的系统和方法。 驱动器系统包括壳体，位于壳体中并连接到驱动力的端口，以及通过驱动力在壳体内移动的惯性驾驶员。 通道形成在壳体中并且从壳体中的第一开口穿过惯性驱动器延伸到壳体中的第二开口。 惯性驾驶员接收通过通道延伸的医疗装置，并且当惯性驾驶员被驱动力移动时，该医疗装置接合医疗装置以给予振荡运动。 所施加的振荡运动沿着医疗装置作为波导传播，以将振荡运动传递到接收医疗过程的组织以执行MRE过程。

公开(公告)号：US20110092798A1

公开(公告)日：2011-04-21

申请号：US12935968

申请日：2009-04-03

申请人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

发明人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

IPC分类号： A61B5/055

CPC分类号： G01R33/56358 ,  A61B5/0051 ,  A61B5/416

摘要： A method for magnetic resonance elastography (“MRE”) is described, in which an MRE inversion that accounts for waves propagating in a finite, bounded media is employed. A vibratory motion is induced in a subject and MRE is performed to measure one or more components of the resulting displacement produced in the subject. This displacement data is subsequently filtered to provide a more accurate and computationally efficient method of inversion. Wave equations based on the geometry of the bounded media are then utilized to calculate the material properties of the subject. Such a method allows for the performance of MRE on tissues such as the heart, eye, bladder, and prostate with more accurate results.

摘要翻译： 描述了一种用于磁共振弹性成像（“MRE”）的方法，其中采用考虑在有限的有界介质中传播的波的MRE反演。 在受试者中诱发振动，并执行MRE以测量在受试者中产生的所得到的位移的一个或多个成分。 随后对该位移数据进行滤波以提供更精确和计算上有效的反演方法。 然后利用基于有界介质的几何形状的波动方程来计算受试者的材料性质。 这种方法允许在更精确的结果上在诸如心脏，眼睛，膀胱和前列腺的组织上表现MRE。

公开(公告)号：US20090295387A1

公开(公告)日：2009-12-03

申请号：US12418218

申请日：2009-04-03

申请人： Richard L. Ehman ,  Meng Yin ,  Kevin J. Glaser

发明人： Richard L. Ehman ,  Meng Yin ,  Kevin J. Glaser

IPC分类号： G01R33/48

CPC分类号： G01R33/56358 ,  A61B5/0051 ,  A61B5/416

摘要： A system is configured to produce a stress on a subject while performing a magnetic resonance elastography scan in a magnetic resonance imaging (MRI) system. The system includes an active driver operable to produce an energy configured for a magnetic resonance elastography (MRE) process. A passive actuator is configured to be positioned in the MRI system and to be coupled to the subject. The system includes a tube coupling the active driver to the passive actuator to deliver the energy produced by the active driver to the passive actuator, and a strap coupled to the passive actuator. The strap is configured to be disposed around the subject. The strap includes a substantially inelastic material configured to convert the energy delivered to the passive actuator from the tube into shear waves with the subject for use in the MRE process.

摘要翻译： 一种系统被配置为在磁共振成像（MRI）系统中执行磁共振弹性成像扫描时在对象上产生应力。 该系统包括可操作以产生为磁共振弹性成像（MRE）过程配置的能量的主动驱动器。 无源致动器被配置为定位在MRI系统中并且被耦合到对象。 该系统包括将有源驱动器耦合到无源致动器以将由主动驱动器产生的能量传递到无源致动器的管和耦合到被动致动器的条带。 带被配置为围绕被摄体设置。 皮带包括基本上无弹性的材料，其被配置成将从管中输送到被动致动器的能量转换成与MRE过程中使用的被检体的剪切波。