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1.发明授权公开(公告)号：US07837042B2
公开(公告)日：2010-11-23
申请号：US11573333
申请日：2005-08-09
申请人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： B01D63/021 , A61M2209/06 , B01D65/022 , B01D65/10 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2313/23 , B01D2321/346 , B01D2323/34 , B01D2325/022 , Y10T428/249958
摘要： The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.
摘要翻译： 本发明涉及一种包含聚砜型选择性渗透性中空纤维膜的中空纤维膜组件，其包含聚砜基树脂和亲水性聚合物作为主要成分，其中（A）亲水性聚合物在内表面最上层中的含量 的中空纤维膜的至少比膜的内表面的邻近层中的亲水性聚合物的含量大至少1.1倍，（B）亲水性聚合物在外表面的最上层中的含量 中空纤维膜比膜的内表面的最上层中的亲水性聚合物的含量大至少1.1倍。 中空纤维膜组件暴露于放射线，条件是中空纤维膜周围的环境气氛的氧浓度为0.001〜0.1％，中空纤维膜的水分含量为 0.2〜7质量％。
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2.发明申请公开(公告)号：US20080044643A1
公开(公告)日：2008-02-21
申请号：US11573333
申请日：2005-08-09
申请人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： B01D63/021 , A61M2209/06 , B01D65/022 , B01D65/10 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2313/23 , B01D2321/346 , B01D2323/34 , B01D2325/022 , Y10T428/249958
摘要： The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.
摘要翻译： 本发明涉及一种包含聚砜型选择性渗透性中空纤维膜的中空纤维膜组件，其包含聚砜基树脂和亲水性聚合物作为主要成分，其中（A）亲水性聚合物在内表面最上层中的含量 的中空纤维膜的至少比膜的内表面的邻近层中的亲水性聚合物的含量大至少1.1倍，（B）亲水性聚合物在外表面的最上层中的含量 中空纤维膜比膜的内表面的最上层中的亲水性聚合物的含量大至少1.1倍。 中空纤维膜组件暴露于放射线，条件是中空纤维膜周围的环境气氛的氧浓度为0.001〜0.1％，中空纤维膜的水分含量为 0.2〜7质量％。
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3.发明申请Highly Water Permeable Hollow Fiber Membrane Type Blood Purifier and Process for Manufacturing the Same 审中-公开高透水中空纤维膜型血液净化器及其制造方法公开(公告)号：US20080000830A1
公开(公告)日：2008-01-03
申请号：US11573339
申请日：2005-08-08
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Noriko Monden , Shinya Koyama , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Noriko Monden , Shinya Koyama , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： B01D69/02 , A61L2/081 , A61L2/186 , A61L2202/24 , B01D67/009 , B01D67/0097 , B01D69/08 , B01D71/68 , B01D2323/12 , B01D2323/30 , B01D2323/34 , B01D2325/02 , B01D2325/022 , B01D2325/20
摘要： The present invention relates to a highly water-permeable hollow fiber membrane type blood purifier which comprises hydrophobic polymer hollow fiber membranes each containing a hydrophilic polymer, wherein the hollow fiber membrane has a hydrophilic polymer content of 25 to 50 mass % and a ratio of hole areas of 8 to 25% at its outer surface, and has a thickness non-uniformity degree of 0.6 or more, a thickness of 10 to 60 μm and a burst pressure of 0.5 to 2 MPa, and which is characterized in that the blood purifier has a water permeability of 150 to 2,000 ml/m2/hr/mmHg, and in that said blood purifier is exposed to radioactive rays on conditions that the oxygen concentration of an ambient atmosphere around the hollow fiber membranes is from 0.001% inclusive to 0.1% inclusive, and that the moisture content of the hollow fiber membrane to its weight is from 0.2 mass % inclusive to 7 mass % inclusive. The present invention also relates to a process for manufacturing the same-blood purifier.
摘要翻译： 本发明涉及一种高透水性中空纤维膜型血液净化器，其包含各自含有亲水性聚合物的疏水性聚合物中空纤维膜，其中，中空纤维膜的亲水性聚合物含量为25〜50质量％，孔的比例 其外表面的面积为8〜25％，厚度不均匀度为0.6以上，厚度为10〜60μm，爆破压力为0.5〜2MPa，其特征在于，所述血液净化器 具有150-2,000ml / m 2 / hr / mmHg的透水性，并且在中空纤维膜周围环境气氛的氧气浓度的条件下将所述血液净化器暴露于放射线 为0.001〜0.1％，中空纤维膜的水分含量为0.2质量％以上7质量％以下。 本发明还涉及同一血液净化器的制造方法。
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公开(公告)号：US09050410B2
公开(公告)日：2015-06-09
申请号：US11577209
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/168 , A61L2/087 , A61L2202/22 , A61M1/16 , A61M1/1682 , A61M1/169 , A61M2209/06 , B01D65/022 , B01D67/0011 , B01D67/0097 , B01D69/08 , B01D71/68 , B01D2321/34 , B01D2323/34 , B01D2325/36 , B01D2325/38
摘要： The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis.The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.
摘要翻译： 本发明提供了一种血液净化器，其显示从其选择性渗透性分离膜中提取的过氧化氢的量减少，因此在其半胱氨酸用途的安全性方面是高度可靠的。 本发明涉及一种血液净化器，其包括选择性渗透性分离膜作为主要成分，其特征在于，经过3个月以上从血液净化器除去的选择性渗透性分离膜中提取的过氧化氢的量已经过去 由于通过暴露于放射线和/或电子射线对血液净化器的灭菌不大于10ppm。
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公开(公告)号：US20080087599A1
公开(公告)日：2008-04-17
申请号：US11577235
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/169 , A61L2/087 , A61L2202/22 , A61M1/168 , A61M1/1682 , B01D61/28 , B01D63/02 , B01D65/022 , B01D67/0097 , B01D2321/28 , B01D2321/34
摘要： The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package.The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.
摘要翻译： 本发明提供了一种对血液净化器进行灭菌的方法，该方法有效地减少归因于选择性渗透性分离膜的劣化的血液净化器的提取物的量随着放射线或电子射线暴露期间和之后的时间而变化 ，哪种方法在用于血液渗透治疗时安全性高度可靠。 本发明还提供一种血液净化器包装。 本发明涉及一种用于对通过将相同的血液净化器暴露于放射线和/或电子射线的基本干燥的选择性渗透性分离膜作为主要成分的血液净化器进行灭菌的方法，该方法是 其特征在于，将血液净化器与除氧剂和保湿剂一起密封在包装袋中，或与能够释放水分的除氧剂一起密封，然后通过上述曝光在这样的密封状态下灭菌。
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公开(公告)号：US20080067122A1
公开(公告)日：2008-03-20
申请号：US11577209
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/168 , A61L2/087 , A61L2202/22 , A61M1/16 , A61M1/1682 , A61M1/169 , A61M2209/06 , B01D65/022 , B01D67/0011 , B01D67/0097 , B01D69/08 , B01D71/68 , B01D2321/34 , B01D2323/34 , B01D2325/36 , B01D2325/38
摘要： The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.
摘要翻译： 本发明提供了一种血液净化器，其显示从其选择性渗透性分离膜中提取的过氧化氢的量减少，因此在其半胱氨酸用途的安全性方面是高度可靠的。 本发明涉及一种血液净化器，其包括选择性渗透性分离膜作为主要成分，其特征在于，经过3个月以上从血液净化器除去的选择性渗透性分离膜中提取的过氧化氢的量已经过去 由于通过暴露于放射线和/或电子射线对血液净化器的灭菌不大于10ppm。
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公开(公告)号：US09067178B2
公开(公告)日：2015-06-30
申请号：US11721766
申请日：2005-12-02
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/1621 , A61L2/087 , A61M1/16 , A61M2209/06 , B01D67/0097 , B65B55/19
摘要： Objects of the present invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.
摘要翻译： 本发明的目的是提供一种血液净化器包装，其显示出来自其血液净化器，特别是其选择性可渗透分离膜的材料的提取物的量的增加较少，归因于暴露后随着时间延长的相同材料的劣化 涉及放射线或电子射线，因此在血液渗透使用中的安全性高度可靠，并提供其制造方法。 本发明涉及一种通过包装选择性渗透分离膜作为主要成分的血液净化器而得到的血液净化器包装，其特征在于，将血液净化器与除氧剂一起包装并密封在一起 在25°C相对湿度大于40％RH的条件下能够关闭外部空气和水蒸气的材料
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公开(公告)号：US20080142434A1
公开(公告)日：2008-06-19
申请号：US11721766
申请日：2005-12-20
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/1621 , A61L2/087 , A61M1/16 , A61M2209/06 , B01D67/0097 , B65B55/19
摘要： Objects of the present invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.
摘要翻译： 本发明的目的是提供一种血液净化器包装，其显示出来自其血液净化器，特别是其选择性可渗透分离膜的材料的提取物的量的增加较少，归因于暴露后随着时间延长的相同材料的劣化 涉及放射线或电子射线，因此在血液渗透使用中的安全性高度可靠，并提供其制造方法。 本发明涉及一种通过包装选择性渗透分离膜作为主要成分的血液净化器而得到的血液净化器包装，其特征在于，将血液净化器与除氧剂一起包装并密封在一起 在25°C相对湿度大于40％RH的条件下能够关闭外部空气和水蒸气的材料
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公开(公告)号：US09056280B2
公开(公告)日：2015-06-16
申请号：US11577235
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/169 , A61L2/087 , A61L2202/22 , A61M1/168 , A61M1/1682 , B01D61/28 , B01D63/02 , B01D65/022 , B01D67/0097 , B01D2321/28 , B01D2321/34
摘要： The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package.The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.
摘要翻译： 本发明提供了一种对血液净化器进行灭菌的方法，该方法有效地减少归因于选择性渗透性分离膜的劣化的血液净化器的提取物的量随着放射线或电子射线暴露期间和之后的时间而变化 ，哪种方法在用于血液渗透治疗时安全性高度可靠。 本发明还提供一种血液净化器包装。 本发明涉及一种用于对通过将相同的血液净化器暴露于放射线和/或电子射线的基本干燥的选择性渗透性分离膜作为主要成分的血液净化器进行灭菌的方法，该方法是 其特征在于，将血液净化器与除氧剂和保湿剂一起密封在包装袋中，或与能够释放水分的除氧剂一起密封，然后通过上述曝光在这样的密封状态下灭菌。
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10.发明申请公开(公告)号：US20050063859A1
公开(公告)日：2005-03-24
申请号：US10947323
申请日：2004-09-23
CPC分类号： A61L2/0035 , A61L2202/22 , A61M1/16 , A61M2209/06 , B01D65/022 , B01D67/0097 , B01D2321/346
摘要： A hollow fiber blood-processing device comprises a bundle of hollow fibers and is sealed in a gas-impermeable container together with a deoxidizer of a water-releasing type and radiation sterilized. The blood processing device is produced by a method comprising the steps of sealing a hollow fiber blood-processing device in a gas-impermeable container together with a deoxidizer of a water-releasing type, and radiation sterilizing the blood-processing device held in the sealed gas-impermeable container.
摘要翻译： 中空纤维血液处理装置包括一束中空纤维，并与排水型脱氧剂一起密封在不透气容器中并进行辐射灭菌。 血液处理装置的制造方法包括以下步骤：将不透气容器中的中空纤维血液处理装置与脱水剂的脱氧剂一起密封，并将保存在密封的血液处理装置 不透气容器
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