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    Bundle of selectively permeable polysulfone-based hollow fiber membranes and process for manufacturing same
    6.
    发明申请
    Bundle of selectively permeable polysulfone-based hollow fiber membranes and process for manufacturing same 审中-公开
    选择性渗透性聚砜基中空纤维膜束及其制造方法

    公开(公告)号：US20070114167A1

    公开(公告)日：2007-05-24

    申请号：US10582052

    申请日：2004-12-08

    申请人： Kimihiro Mabuchi ,  Noriyuki Tamamura ,  Hidehiko Sakurai ,  Noriaki Kato ,  Hiroshi Shibano ,  Katsuhiko Nose

    发明人： Kimihiro Mabuchi ,  Noriyuki Tamamura ,  Hidehiko Sakurai ,  Noriaki Kato ,  Hiroshi Shibano ,  Katsuhiko Nose

    IPC分类号： B01D63/00

    CPC分类号： B01D69/08 ,  B01D67/009 ,  B01D67/0095 ,  B01D69/02 ,  B01D71/44 ,  B01D71/68 ,  B01D2323/02 ,  B01D2323/12 ,  B01D2323/30 ,  B01D2323/34

    摘要： The present invention provides polysulfone-based hollow fiber membranes having high water permeable performance and for use in therapy of chronic renal failures, said hollow fiber membranes having high safety and high stability in performance and being excellent in module-fabricating workability. The present invention also provides a process for manufacturing the same. The present invention relates to a bundle of a plurality of selectively permeable polysulfone-based hollow fiber membranes wherein the amount of a hydrophilic polymer eluting from each hollow fiber membrane is not larger than 10 ppm, and wherein the content of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %, and this bundle is characterized in that any of extracted solutions from ten fractions of said bundle, obtained by dividing the bundle at substantially regular intervals along the lengthwise direction, shows a maximum value of smaller than 0.10 in UV absorbance at a wavelength of 220 to 350 nm, with the proviso that the extracted solutions are obtained by the extraction method for tests regulated in the approval manufacturing standards for dialytic artificial kidney devices; and in that the difference between the maximum and the minimum out of the maximum values of UV absorbance of the extracted solutions from the respective fractions is not larger than 0.05.

    摘要翻译： 本发明提供了具有高透水性的聚砜基中空纤维膜，用于治疗慢性肾功能衰竭，所述中空纤维膜具有高安全性和高性能稳定性，模块制造加工性优异。 本发明还提供一种制造该方法的方法。 本发明涉及多根选择性渗透性聚砜系中空纤维膜束，其中从各中空纤维膜洗出的亲水性聚合物的量不大于10ppm，其中亲水性聚合物在外层 中空纤维膜的表面为25〜50质量％，该束的特征在于，通过沿着长度方向以基本上规则的间隔分割束而获得的所述束的十个部分的提取液中的任何一个显示最大值 波长为220〜350nm时紫外吸光度小于0.10，条件是通过透析人造肾装置的认可制造标准规定的试验提取方法获得提取液; 并且来自各个馏分的萃取溶液的UV吸光度的最大值的最大值和最小值之间的差异不大于0.05。

    Polysulfone-based hollow-fiber membrane with selective permeability
    7.
    发明授权
    Polysulfone-based hollow-fiber membrane with selective permeability 有权
    具有选择性渗透性的聚砜基中空纤维膜

    公开(公告)号：US07638052B2

    公开(公告)日：2009-12-29

    申请号：US10559544

    申请日：2004-06-02

    申请人： Kimihiro Mabuchi ,  Noriyuki Tamamura ,  Hidehiko Sakurai ,  Noriaki Kato ,  Hiroshi Shibano ,  Katsuhiko Nose

    发明人： Kimihiro Mabuchi ,  Noriyuki Tamamura ,  Hidehiko Sakurai ,  Noriaki Kato ,  Hiroshi Shibano ,  Katsuhiko Nose

    IPC分类号： B01D33/21 ,  B01D39/00

    CPC分类号： B01D71/68 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/087 ,  B01D2323/30 ,  B01D2325/022 ,  Y10T442/608 ,  Y10T442/609 ,  Y10T442/612 ,  Y10T442/696

    摘要： The present invention provides a polysulfone type hollow fiber membrane which is reliable in safety and stability of performance and is easily incorporated into a module, and thus can be suitably used in a highly water permeable blood purifier for use in a therapy of chronic renal failure.The present invention relates to a polysulfone type selectively permeable hollow fiber membrane comprising a polysulfone type resin and a hydrophilic polymer as main components, and characterized in that (A) the content of the hydrophilic polymer in the uppermost layer of a surface of the polysulfone type hollow fiber membrane on the blood-contacting side is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the surface on the blood-contacting side, and (B) the content of the hydrophilic polymer in the uppermost layer of the other surface of the polysulfone type hollow fiber membrane, i.e., the reverse side of the surface on the blood-contacting side, is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the surface on the blood-contacting side.

    摘要翻译： 本发明提供一种聚砜型中空纤维膜，其性能安全可靠，易于加入到模块中，因此可适用于用于慢性肾衰竭治疗的高水溶性血液净化器。 本发明涉及一种聚砜型选择性渗透性中空纤维膜，其包含聚砜型树脂和亲水性聚合物作为主要成分，其特征在于，（A）聚砜型表面最上层中的亲水性聚合物的含量 血液接触侧的中空纤维膜比血液接触侧表面的近层中的亲水性聚合物的含量为至少1.1倍，（B）最上层的亲水性聚合物的含量 的聚砜型中空纤维膜的另一表面，即血液接触侧的表面的相反侧，比血液表面最上层的亲水性聚合物的含量大至少1.1倍 接触方

    Polysulfone-based hollow-fiber membrane with selective permeability
    8.
    发明申请
    Polysulfone-based hollow-fiber membrane with selective permeability 有权

    公开(公告)号：US20060205309A1

    公开(公告)日：2006-09-14

    申请号：US10559544

    申请日：2004-06-02

    申请人： Kimihiro Mabuchi ,  Noriyuki Tamamura

    发明人： Kimihiro Mabuchi ,  Noriyuki Tamamura

    IPC分类号： D04H1/00 ,  D04H3/00

    CPC分类号： B01D71/68 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/087 ,  B01D2323/30 ,  B01D2325/022 ,  Y10T442/608 ,  Y10T442/609 ,  Y10T442/612 ,  Y10T442/696

    摘要： The present invention provides a polysulfone type hollow fiber membrane which is reliable in safety and stability of performance and is easily incorporated into a module, and thus can be suitably used in a highly water permeable blood purifier for use in a therapy of chronic renal failure. The present invention relates to a polysulfone type selectively permeable hollow fiber membrane comprising a polysulfone type resin and a hydrophilic polymer as main components, and characterized in that (A) the content of the hydrophilic polymer in the uppermost layer of a surface of the polysulfone type hollow fiber membrane on the blood-contacting side is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the surface on the blood-contacting side, and (B) the content of the hydrophilic polymer in the uppermost layer of the other surface of the polysulfone type hollow fiber membrane, i.e., the reverse side of the surface on the blood-contacting side, is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the surface on the blood-contacting side.