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公开(公告)号：US20100221232A1
公开(公告)日：2010-09-02
申请号：US11452873
申请日：2006-06-13
CPC分类号： C07K14/50 , A01K2207/12 , A01K2267/035 , A61K38/1825 , C12N15/11 , C12N2799/027
摘要： The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).
摘要翻译： 本公开提供了用于增加骨生长和/或增强伤口愈合的组合物和方法，例如骨折修复。 本公开提供了可用于促进骨生长的重组核酸。 例如，本公开提供编码成纤维细胞生长因子-2（FGF-2）类似物的重组核酸。 本公开还提供了掺入这些核酸的载体和细胞，以及由它们编码的FGF-2类似物。 本公开还提供了骨髓移植的小鼠系统以及用于生产的方法以及使用该系统的方法。 还提供诱导造血干细胞分化和/或诱导分化的方法，以及用于增强骨生长和/或伤口修复（例如，骨折修复）的方法。
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公开(公告)号：US08772571B2
公开(公告)日：2014-07-08
申请号：US12879842
申请日：2010-09-10
CPC分类号： C07K14/50 , A01K2207/12 , A01K2267/035 , A61K38/1825 , C12N15/11 , C12N2799/027
摘要： The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).
摘要翻译： 本公开提供了用于增加骨生长和/或增强伤口愈合的组合物和方法，例如骨折修复。 本公开提供了可用于促进骨生长的重组核酸。 例如，本公开提供编码成纤维细胞生长因子-2（FGF-2）类似物的重组核酸。 本公开还提供了掺入这些核酸的载体和细胞，以及由它们编码的FGF-2类似物。 本公开还提供了骨髓移植的小鼠系统以及用于生产的方法以及使用该系统的方法。 还提供诱导造血干细胞分化和/或诱导分化的方法，以及用于增强骨生长和/或伤口修复（例如，骨折修复）的方法。
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公开(公告)号：US20110004947A1
公开(公告)日：2011-01-06
申请号：US12879842
申请日：2010-09-10
CPC分类号： C07K14/50 , A01K2207/12 , A01K2267/035 , A61K38/1825 , C12N15/11 , C12N2799/027
摘要： The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).
摘要翻译： 本公开提供了用于增加骨生长和/或增强伤口愈合的组合物和方法，例如骨折修复。 本公开提供了可用于促进骨生长的重组核酸。 例如，本公开提供编码成纤维细胞生长因子-2（FGF-2）类似物的重组核酸。 本公开还提供了掺入这些核酸的载体和细胞，以及由它们编码的FGF-2类似物。 本公开还提供了骨髓移植的小鼠系统以及用于生产的方法以及使用该系统的方法。 还提供诱导造血干细胞分化和/或诱导分化的方法，以及用于增强骨生长和/或伤口修复（例如，骨折修复）的方法。
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公开(公告)号：US07816140B2
公开(公告)日：2010-10-19
申请号：US11452873
申请日：2006-06-13
CPC分类号： C07K14/50 , A01K2207/12 , A01K2267/035 , A61K38/1825 , C12N15/11 , C12N2799/027
摘要： The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).
摘要翻译： 本公开提供了用于增加骨生长和/或增强伤口愈合的组合物和方法，例如骨折修复。 本公开提供了可用于促进骨生长的重组核酸。 例如，本公开提供编码成纤维细胞生长因子-2（FGF-2）类似物的重组核酸。 本公开还提供了掺入这些核酸的载体和细胞，以及由它们编码的FGF-2类似物。 本公开还提供了骨髓移植的小鼠系统以及用于生产的方法以及使用该系统的方法。 还提供诱导造血干细胞分化和/或诱导分化的方法，以及用于增强骨生长和/或伤口修复（例如，骨折修复）的方法。
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