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    INTENSITY-MODULATED, CONE-BEAM COMPUTED TOMOGRAPHIC IMAGING SYSTEM, METHODS, AND APPARATUS
    1.
    发明申请
    INTENSITY-MODULATED, CONE-BEAM COMPUTED TOMOGRAPHIC IMAGING SYSTEM, METHODS, AND APPARATUS 审中-公开
    强度调制，电脑光束计算机图像成像系统，方法和设备

    公开(公告)号：US20100119033A1

    公开(公告)日：2010-05-13

    申请号：US12617510

    申请日：2009-11-12

    申请人： King C. Li ,  Xiaobo Zhou ,  Goetz Benndorf

    发明人： King C. Li ,  Xiaobo Zhou ,  Goetz Benndorf

    IPC分类号： H05G1/60 ,  G21K1/02

    CPC分类号： A61B6/06 ,  A61B6/027

    摘要： Disclosed are methods for reconstructing a three-dimensional image of an object's volume of interest using computed tomography that employs conical-beam, intensity-modulated projections of this object. In one embodiment, a plurality of collimating devices serves to modulate the aperture of the radiation source thereby acting to modulate the intensity of the source upon the object. Also provided are image processing devices, examination apparatus, as well as a computer-readable medium and a program element adapted and configured to perform aspects of the methods disclosed herein.

    摘要翻译： 公开了使用采用该物体的锥形束，强度调制投影的计算机断层摄影重建物体感兴趣体积的三维图像的方法。 在一个实施例中，多个准直装置用于调制辐射源的孔径，从而用于调节源对象的强度。 还提供了图像处理装置，检查装置以及适于和配置为执行本文公开的方法的方面的计算机可读介质和程序元件。

    Small molecules for imaging protein-protein interactions
    2.
    发明授权
    Small molecules for imaging protein-protein interactions 有权
    用于成像蛋白质 - 蛋白相互作用的小分子

    公开(公告)号：US07943775B2

    公开(公告)日：2011-05-17

    申请号：US11762579

    申请日：2007-06-13

    申请人： King C. Li ,  S. Narasimhan Danthi

    发明人： King C. Li ,  S. Narasimhan Danthi

    IPC分类号： C07D211/06 ,  A61K49/00 ,  C07C233/05

    CPC分类号： C07C237/40 ,  A61K49/0043 ,  A61K49/0052 ,  G01N2333/4709

    摘要： A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional compound of which one functionality binds to the target protein and the second functionality binds to a chaperone protein that is present in the tissue of interest. The two functionalities have different binding affinities, the target-binding functionality having the greater binding affinity, with the result that the bifunctional compound preferentially remains in the tissue when bound to the chaperone and then the target protein while bifunctional compound that is not bound to the target protein will leave the tissue. The inclusion of the chaperone allows the imaging process to detect the non-aggregated proteins by way of the label and the difference in kinetics of the binding to the chaperone and the target protein permits one to distinguish between binding of the bifunctional molecule to the chaperone only and binding to the chaperone and then to the target protein. Certain intermediates toward the synthesis of these bifunctional compounds are novel by themselves, and labeled bifunctional molecules in general that utilize a lysine linker are also disclosed as a novel class of compounds.

    摘要翻译： 成像组织以在其聚集成斑块之前检测淀粉样蛋白沉积物或其它靶蛋白的存在，借助于施用其中一个功能性与目标蛋白质结合的标记的双功能化合物，并且第二官能团结合于分子伴侣 存在于感兴趣组织中的蛋白质。 这两个功能具有不同的结合亲和力，靶结合功能具有更大的结合亲和力，结果是当与分子伴侣结合时，双功能化合物优先保留在组织中，然后与靶蛋白结合，而不结合到 靶蛋白会离开组织。 分子伴侣的包含允许成像过程通过标记检测非聚集的蛋白质，并且与伴侣和靶蛋白结合的动力学差异允许区分双功能分子与分子伴侣的结合 并结合分子伴侣，然后结合到靶蛋白。 合成这些双功能化合物的某些中间体本身是新的，并且一般使用赖氨酸连接物的标记的双功能分子也被公开为新类化合物。

    Containment tubes and imaging systems employing same
    3.
    发明授权
    Containment tubes and imaging systems employing same 失效
    收容管和使用其的成像系统

    公开(公告)号：US08359084B2

    公开(公告)日：2013-01-22

    申请号：US12056950

    申请日：2008-03-27

    申请人： Alan Love ,  King C. Li

    发明人： Alan Love ,  King C. Li

    IPC分类号： A61B5/055

    CPC分类号： A61N5/1049 ,  A61B5/0555 ,  A61B5/702 ,  A61B6/03 ,  A61B6/037 ,  A61B6/04 ,  A61B6/4423 ,  A61B90/40 ,  A61G10/005

    摘要： An isolation system with imaging or radiation therapy capability is disclosed. At least one containment barrier (14, 15, 16, 17) defines an isolation region (10). An imaging or therapy system (20) is disposed outside of the isolation region. The containment barrier includes a substantially hollow tubular extension (24, 42, 44, 124, 224, 324) protruding away from the isolation region (10). The substantially hollow tubular extension surrounds an interior volume (26) that is in fluid communication with the isolation region and is in fluid isolation from the imaging or therapy system. The substantially hollow tubular extension is made at least partially of a material providing operative communication between the imaging or therapy system and the interior volume of the substantially hollow tubular extension.

    摘要翻译： 公开了具有成像或放射治疗能力的隔离系统。 至少一个容纳挡板（14,15,16,17）限定隔离区域（10）。 成像或治疗系统（20）设置在隔离区域的外部。 容纳挡板包括远离隔离区域（10）突出的基本上中空的管状延伸部（24,42,44，124,224,324）。 基本上中空的管状延伸部围绕与隔离区域流体连通并与成像或治疗系统流体隔离的内部容积（26）。 至少部分地由基本上中空的管状延伸部分提供成像或治疗系统与基本中空管状延伸部的内部容积之间的操作性连通的材料。

    Integrin α-v β-3 antagonists for use in imaging and therapy
    4.
    发明授权
    Integrin α-v β-3 antagonists for use in imaging and therapy 有权
    用于成像和治疗的整合素α-vβ-3拮抗剂

    公开(公告)号：US07300940B2

    公开(公告)日：2007-11-27

    申请号：US10911988

    申请日：2004-08-04

    申请人： S. Narasimhan Danthi ,  King C. Li ,  Christopher A. Burnett

    发明人： S. Narasimhan Danthi ,  King C. Li ,  Christopher A. Burnett

    IPC分类号： C07D239/42 ,  A61K31/505

    CPC分类号： C07D239/14

    摘要： Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-β-alanine nucleus exhibit increased binding affinity for the αvβ3 receptor when further substituted on the sulfonyl moiety with an N-amino alkycarbamyl group or a butyloxycarbonylamino alkylcarbamoyl group or similar groups.

    摘要翻译： 在磺酰基氨基-β-丙氨酸核上分子结构包括四氢吡啶基氨基乙氧基苯甲酰基的整联蛋白受体拮抗剂在磺酰基部分用N-氨基烷基氨基甲酰基或丁基氧基羰基氨基烷基氨基甲酰基或类似基团进一步取代时，表现出对α2β3受体的结合亲和力。