中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

17 records (took 0.014 seconds)

    Processes for the synthesis of olanzapine
    1.
    发明授权
    Processes for the synthesis of olanzapine 失效
    奥氮平合成方法

    公开(公告)号：US07863442B2

    公开(公告)日：2011-01-04

    申请号：US11976978

    申请日：2007-10-30

    Applicant: Kiran Kumar Kothakonda ,  Daqing Che ,  Bhaskar Reddy Guntoori

    Inventor： Kiran Kumar Kothakonda ,  Daqing Che ,  Bhaskar Reddy Guntoori

    IPC: C07D495/02

    CPC classification number: C07D495/04

    Abstract: There is provided a process for the preparation of olanzapine comprising: i) reacting 4-amino-2-methyl-10H-thieno-[2,3-b][1,5]benzodiazepine and N-methylpiperazine in a C1 to C4 alcoholic solvent or mixture thereof at suitable temperature and for a suitable time, ii) cooling the reaction mixture, and iii) isolating the precipitated olanzapine.

    Abstract translation: 提供了一种制备奥氮平的方法，其包括：i）使4-氨基-2-甲基-10H-噻吩并[2,3-b] [1,5]苯并二氮杂和N-甲基哌嗪在C1至C4醇中反应 溶剂或其混合物在合适的温度和合适的时间，ii）冷却反应混合物，和iii）分离沉淀的奥氮平。

    Amorphous form of rifaximin and processes for its preparation
    2.
    发明授权
    Amorphous form of rifaximin and processes for its preparation 有权
    无定形形式的利福昔明及其制备方法

    公开(公告)号：US07709634B2

    公开(公告)日：2010-05-04

    申请号：US11902211

    申请日：2007-09-20

    Applicant: Kiran Kumar Kothakonda ,  Daqing Che

    Inventor： Kiran Kumar Kothakonda ,  Daqing Che

    IPC: C07D498/22

    CPC classification number: C07D498/22

    Abstract: A stable amorphous form of rifaximin is disclosed. This form is chemically and polymorphically stable on storage and can be prepared by dissolving rifaximin in a solvent to form a solution, which is precipitated by adding an anti-solvent and isolating of the precipitated amorphous rifaximin as an end product.

    Abstract translation: 公开了稳定的无定形形式的利福昔明。 这种形式在储存时是化学上和多晶型稳定的，并且可以通过将利福昔明溶解在溶剂中以形成溶液来制备，所述溶液通过加入抗溶剂和分离沉淀的无定形的利福昔明作为最终产物而沉淀。

    Processes for the synthesis of olanzapine
    3.
    发明申请
    Processes for the synthesis of olanzapine 失效
    奥氮平合成方法

    公开(公告)号：US20080319189A1

    公开(公告)日：2008-12-25

    申请号：US11976978

    申请日：2007-10-30

    Applicant: Kiran Kumar Kothakonda ,  Daqing Che ,  Bhaskar Reddy Guntoori

    Inventor： Kiran Kumar Kothakonda ,  Daqing Che ,  Bhaskar Reddy Guntoori

    IPC: C07D243/10

    CPC classification number: C07D495/04

    Abstract: There is provided a process for the preparation of olanzapine comprising: i) reacting 4-amino-2-methyl-10H-thieno-[2,3-b][1,5]benzodiazepine and N-methylpiperazine in a C1 to C4 alcoholic solvent or mixture thereof at suitable temperature and for a suitable time, ii) cooling the reaction mixture, and iii) isolating the precipitated olanzapine.

    Abstract translation: 提供了一种制备奥氮平的方法，其包括：i）使4-氨基-2-甲基-10H-噻吩并[2,3-b] [1,5]苯并二氮杂和N-甲基哌嗪在C1至C4醇中反应 溶剂或其混合物在合适的温度和合适的时间，ii）冷却反应混合物，和iii）分离沉淀的奥氮平。

    Novel process to Form-I of olanzapine
    4.
    发明申请
    Novel process to Form-I of olanzapine 审中-公开
    奥氮平的一种新方法

    公开(公告)号：US20080312433A1

    公开(公告)日：2008-12-18

    申请号：US11976944

    申请日：2007-10-30

    Applicant: Daqing Che ,  Kiran Kumar Kothakonda ,  Cameron L. McPhail ,  Bhaskar Reddy Guntoori

    Inventor： Daqing Che ,  Kiran Kumar Kothakonda ,  Cameron L. McPhail ,  Bhaskar Reddy Guntoori

    IPC: C07D495/04

    CPC classification number: C07D495/04

    Abstract: A process for obtaining crystalline Form-I olanzapine comprising the following: a) dissolving crude olanzapine in a solvent to form a solution, b) optionally drying by azeotropic distillation to remove water, c) precipitating by adding the solution of step (a) to an antisolvent, and d) isolating the precipitated crystalline Form-I olanzapine by filtration and drying at ambient temperature.

    Abstract translation: 一种获得结晶形式的奥氮平的方法，包括以下步骤：a）将粗奥氮平溶于溶剂中以形成溶液，b）任选地通过共沸蒸馏干燥除去水，c）通过将步骤（a）的溶液加入到 反溶剂，以及d）通过过滤并在环境温度下干燥分离析出的结晶的形式I奥氮平。

    Amorphous form of rifaximin and processes for its preparation
    5.
    发明申请
    Amorphous form of rifaximin and processes for its preparation 有权
    无定形形式的利福昔明及其制备方法

    公开(公告)号：US20090082558A1

    公开(公告)日：2009-03-26

    申请号：US11902211

    申请日：2007-09-20

    Applicant: Kiran Kumar Kothakonda ,  Daqing Che

    Inventor： Kiran Kumar Kothakonda ,  Daqing Che

    IPC: C07D498/22

    CPC classification number: C07D498/22

    Abstract: A stable amorphous form of rifaximin is disclosed. This form is chemically and polymorphically stable on storage and can be prepared by dissolving rifaximin in a solvent to form a solution, which is precipitated by adding an anti-solvent and isolating of the precipitated amorphous rifaximin as an end product.

    Abstract translation: 公开了稳定的无定形形式的利福昔明。 这种形式在储存时是化学上和多晶型稳定的，并且可以通过将利福昔明溶解在溶剂中以形成溶液来制备，所述溶液通过加入抗溶剂和分离沉淀的无定形的利福昔明作为最终产物而沉淀。

Patent Agency Ranking