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公开(公告)号：US08637651B2
公开(公告)日：2014-01-28
申请号：US12724403
申请日：2010-03-15
申请人： Kirk E. Apt , James Casey Lippmeier , David Simpson , Jun Wang , James P. Wynn , Ross Zirkle
发明人： Kirk E. Apt , James Casey Lippmeier , David Simpson , Jun Wang , James P. Wynn , Ross Zirkle
CPC分类号： C12P21/00 , C07K14/37 , C07K14/705 , C12N9/2431 , C12N15/79 , C12N15/80 , C12P21/005 , C12R1/90 , C12Y302/01026
摘要： The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
摘要翻译： 本发明涉及神经胶霉病菌门的重组细胞和微生物及其在异源蛋白质生产中的用途。 用于有效生产和任选地从重组宿主细胞和微生物分泌多肽的新型启动子，终止子和信号序列也包括在本发明中。
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公开(公告)号：US20100233760A1
公开(公告)日：2010-09-16
申请号：US12724403
申请日：2010-03-15
申请人： Kirk E. Apt , James Casey Lippmeier , David Simpson , Jun Wang , James P. Wynn , Ross Zirkle
发明人： Kirk E. Apt , James Casey Lippmeier , David Simpson , Jun Wang , James P. Wynn , Ross Zirkle
CPC分类号： C12P21/00 , C07K14/37 , C07K14/705 , C12N9/2431 , C12N15/79 , C12N15/80 , C12P21/005 , C12R1/90 , C12Y302/01026
摘要： The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
摘要翻译： 本发明涉及神经胶霉病菌门的重组细胞和微生物及其在异源蛋白质生产中的用途。 用于有效生产和任选地从重组宿主细胞和微生物分泌多肽的新型启动子，终止子和信号序列也包括在本发明中。
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公开(公告)号：US20090064567A1
公开(公告)日：2009-03-12
申请号：US12230921
申请日：2008-09-08
申请人： James Casey Lippmeier , Joseph W. Pfeifer, III , Jon Milton Hansen , Kirk E. Apt , William Robert Barclay , Paul Warren Behrens , David Christian Martin
发明人： James Casey Lippmeier , Joseph W. Pfeifer, III , Jon Milton Hansen , Kirk E. Apt , William Robert Barclay , Paul Warren Behrens , David Christian Martin
CPC分类号： C12P7/6472 , C10L1/02 , C10L1/026 , C10L2200/0469 , C10L2270/026 , C10L2270/04 , C10L2290/26 , C12P7/649 , Y02E50/13 , Y02P30/20
摘要： The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
摘要翻译： 本发明提供生物油及其方法和用途。 生物油优选通过使用含纤维素原料作为主要碳源的一种或多种微生物的异养发酵产生。 本发明还提供了使用生物油制备基于脂质的生物燃料和食品，营养和药物产品的方法。
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公开(公告)号：US09453172B2
公开(公告)日：2016-09-27
申请号：US13401521
申请日：2012-02-21
申请人： James Casey Lippmeier , Joseph W. Pfeifer, III , Jon Milton Hansen , Kirk E. Apt , William Robert Barclay , Paul Warren Behrens , David Christian Martin
发明人： James Casey Lippmeier , Joseph W. Pfeifer, III , Jon Milton Hansen , Kirk E. Apt , William Robert Barclay , Paul Warren Behrens , David Christian Martin
CPC分类号： C12P7/6472 , C10L1/02 , C10L1/026 , C10L2200/0469 , C10L2270/026 , C10L2270/04 , C10L2290/26 , C12P7/649 , Y02E50/13 , Y02P30/20
摘要： The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
摘要翻译： 本发明提供生物油及其方法和用途。 生物油优选通过使用含纤维素原料作为主要碳源的一种或多种微生物的异养发酵产生。 本发明还提供了使用生物油制备基于脂质的生物燃料和食品，营养和药物产品的方法。
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公开(公告)号：US07252979B2
公开(公告)日：2007-08-07
申请号：US11313524
申请日：2005-12-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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6.发明授权公开(公告)号：US07745183B2
公开(公告)日：2010-06-29
申请号：US11738414
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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7.发明申请Production of High Levels of DHA in Microalgae Using Modified Amounts of Chloride and Potassium 审中-公开使用改性量的氯化物和钾生产微藻中高含量的DHA公开(公告)号：US20120071677A1
公开(公告)日：2012-03-22
申请号：US13306370
申请日：2011-11-29
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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8.发明授权Production of DHA in microalgae in medium having modified amounts of chloride ion and potassium ion 失效在具有改变量的氯离子和钾离子的培养基中，在微藻中生产DHA公开(公告)号：US07871809B2
公开(公告)日：2011-01-18
申请号：US11738430
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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9.发明授权Production of high levels of DHA in microalgae using modified amounts of chloride and potassium 有权使用改良量的氯化物和钾在微藻中生产高水平的DHA公开(公告)号：US07163811B2
公开(公告)日：2007-01-16
申请号：US10957075
申请日：2004-10-01
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US08008050B2
公开(公告)日：2011-08-30
申请号：US11738422
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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