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    Nanostructured separation and analysis devices for biological membranes
    3.
    发明授权
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：US06913697B2

    公开(公告)日：2005-07-05

    申请号：US10338654

    申请日：2003-01-09

    申请人： Gabriel P. Lopez ,  Steven R. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. Brueck ,  Linnea K. Ista

    IPC分类号： B01D11/00 ,  B01D61/14

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。

    Nanostructured separation and analysis devices for biological membranes
    4.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE42249E1

    公开(公告)日：2011-03-29

    申请号：US12217114

    申请日：2008-07-01

    申请人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC分类号： B01D21/00

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nonostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the subtrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures. A fluidic device for separating particles according to size is provided including a fluidic channel, and a matrix comprising a plurality of protrusions within the fluidic channel, wherein the device provides a driving force to the particles being separated through the fluidic channel; and wherein a flow of the driving force from between the protrusions is divided unequally into a major flow component and a minor flow component, each component flowing between subsequent protrusions in the matrix, such that the average direction of the major flow component is not parallel to the average direction of the driving force, and, when particles are introduced into the matrix, particles having a size less than a predetermined critical size are transported generally in the average direction of the driving force, and particles having a size at least that of the critical size are transported generally in the average direction of the major flow component, thereby separating the particles according to size. Methods for separating particles including steps of separation based on size and affinity are also provided.

    摘要翻译： 本发明提供一种非结构化装置，其包括其中包括纳入通道的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述缓冲液包含纳米结构，并且其中所述脂质双层包含至少一个膜相关的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。 提供了一种用于根据尺寸分离颗粒的流体装置，包括流体通道和在流体通道内包括多个突起的基体，其中该装置为通过流体通道分离的颗粒提供驱动力; 并且其中来自所述突起之间的驱动力的流动不均匀地分成主流动分量和小流动分量，每个分量在所述基体中的后续突起之间流动，使得主流动分量的平均方向不平行于 驱动力的平均方向，并且当颗粒被引入到基质中时，尺寸小于预定临界尺寸的颗粒通常沿驱动力的平均方向传送，并且尺寸至少大于 临界尺寸通常沿主流体组分的平均方向输送，从而根据尺寸分离颗粒。 还提供了基于尺寸和亲和力分离包括分离步骤的颗粒的方法。

    Nanostructured separation and analysis devices for biological membranes
    10.
    再颁专利
    Nanostructured separation and analysis devices for biological membranes 有权
    用于生物膜的纳米结构分离和分析装置

    公开(公告)号：USRE42315E1

    公开(公告)日：2011-05-03

    申请号：US11825298

    申请日：2007-07-05

    申请人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    发明人： Gabriel P. Lopez ,  Steven R. J. Brueck ,  Linnea K. Ista

    IPC分类号： B01D15/34

    CPC分类号： G01N27/44773 ,  B82Y30/00 ,  G01N30/00 ,  G01N30/88 ,  G01N2030/8813 ,  Y10S977/717 ,  Y10S977/845 ,  Y10T436/25375 ,  Y10T436/255

    摘要： The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

    摘要翻译： 本发明提供一种纳米结构装置，其包括其中包括纳沟的基板; 和悬浮在或支撑在基底中的脂质双层。 还提供了一种分离方法，包括以下步骤：在基质上支持或悬浮脂质双层; 其中所述底物包含纳米结构，并且其中所述脂质双层包含至少一个膜缔合的生物分子; 并将驱动力施加到脂质双层以将膜相关生物分子与脂质双层分离并将膜相关联的生物分子驱动到纳米结构中。