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公开(公告)号：US10106650B2
公开(公告)日：2018-10-23
申请号：US14117570
申请日：2012-05-14
申请人： Kit S. Lam , Yuanpei Li , Juntao Luo , Kai Xiao
发明人： Kit S. Lam , Yuanpei Li , Juntao Luo , Kai Xiao
IPC分类号： C08G65/334 , A61K47/28 , A61K9/107 , A61K45/06 , C08G83/00 , C08G65/329 , C08L71/02 , A61K31/337 , A61K47/60 , A61K9/127
摘要： The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.
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公开(公告)号：US09579400B2
公开(公告)日：2017-02-28
申请号：US13120140
申请日：2009-09-22
申请人： Kit S. Lam , Juntao Luo
发明人： Kit S. Lam , Juntao Luo
IPC分类号： A61K9/14 , A61K31/337 , A61K31/704 , A61K31/7048 , A61K49/00 , A61K9/107 , A61K9/51 , A61K47/48 , B82Y5/00
CPC分类号： A61K49/0002 , A61K9/1075 , A61K9/5146 , A61K47/48215 , A61K47/488 , A61K47/60 , A61K47/6907 , A61K49/0032 , A61K49/0082 , B82Y5/00
摘要： The present invention provides a nanocarrier having an interior and an exterior, the nanocarrier comprising at least one conjugate, wherein each conjugate includes a polyethylene glycol (PEG) polymer. Each conjugate also includes at least two amphiphilic compounds having both a hydrophilic face and a hydrophobic face. In addition, each conjugate includes an oligomer, wherein at least 2 of the amphiphilic compounds are covalently attached to the oligomer which is covalently attached to the PEG. The nanocarrier is such that each conjugate self-assembles in an aqueous solvent to form the nanocarrier such that a hydrophobic pocket is formed in the interior of the nanocarrier by the orientation of the hydrophobic face of each amphiphilic compound towards each other, and wherein the PEG of each conjugate self-assembles on the exterior of the nanocarrier.
摘要翻译： 本发明提供具有内部和外部的纳米载体，所述纳米载体包含至少一种缀合物，其中每个缀合物包括聚乙二醇（PEG）聚合物。 每个缀合物还包括具有亲水面和疏水性面两者的至少两种两亲性化合物。 此外，每个缀合物包括低聚物，其中至少两个两亲化合物共价连接到共价连接到PEG的低聚物。 纳米载体使得每个缀合物在水性溶剂中自组装形成纳米载体，使得通过每个两亲性化合物的疏水性面向彼此的取向在纳米载体的内部形成疏水性口袋，并且其中PEG 的每个缀合物自组装在纳米载体的外部。
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公开(公告)号：US09296988B2
公开(公告)日：2016-03-29
申请号：US13378540
申请日：2010-06-18
申请人： Ekama Onofiok , Kit S. Lam , Juntao Luo
发明人： Ekama Onofiok , Kit S. Lam , Juntao Luo
IPC分类号： C12N5/00 , C09J129/04 , C08K5/55
CPC分类号： C09J129/04 , C08K5/55 , C12N5/0062 , C12N2533/30
摘要： The present invention provides a cell adhesion matrix having poly(vinyl alcohol) chains crosslinked via carboxy phenyl boronic acid crosslinkers. The cell adhesion matrix can also include a molecular recognition element bound to the poly(vinyl alcohol) chains via a carboxy phenyl boronic acid group, as well as including cells. The present invention also provides a method for making and de-gelling the cell adhesion matrix.
摘要翻译： 本发明提供具有通过羧基苯基硼酸交联剂交联的聚（乙烯醇）链的细胞粘附基质。 细胞粘附基质还可以包括通过羧基苯基硼酸基团与聚（乙烯醇）链结合的分子识别元件，以及包括细胞。 本发明还提供了使细胞粘附基质形成和脱胶的方法。
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公开(公告)号：US20120322145A1
公开(公告)日：2012-12-20
申请号：US13378540
申请日：2010-06-18
申请人： Ekama Onofiok , Kit S. Lam , Juntao Luo
发明人： Ekama Onofiok , Kit S. Lam , Juntao Luo
IPC分类号： C08F116/06 , C12N5/07
CPC分类号： C09J129/04 , C08K5/55 , C12N5/0062 , C12N2533/30
摘要： The present invention provides a cell adhesion matrix having poly(vinyl alcohol) chains crosslinked via carboxy phenyl boronic acid crosslinkers. The cell adhesion matrix can also include a molecular recognition element bound to the poly(vinyl alcohol) chains via a carboxy phenyl boronic acid group, as well as including cells. The present invention also provides a method for making and de-gelling the cell adhesion matrix.
摘要翻译： 本发明提供具有通过羧基苯基硼酸交联剂交联的聚（乙烯醇）链的细胞粘附基质。 细胞粘附基质还可以包括通过羧基苯基硼酸基团与聚（乙烯醇）链结合的分子识别元件，以及包括细胞。 本发明还提供了使细胞粘附基质形成和脱胶的方法。
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公开(公告)号：US20110286915A1
公开(公告)日：2011-11-24
申请号：US13120140
申请日：2009-09-22
申请人： Kit S. Lam , Juntao Luo
发明人： Kit S. Lam , Juntao Luo
IPC分类号： A61K51/12 , A61K9/14 , A61K31/337 , A61P35/00 , A61K31/704 , A61K31/7048 , C07C237/14 , C07C247/06 , A61K49/00 , A61K31/4745
CPC分类号： A61K49/0002 , A61K9/1075 , A61K9/5146 , A61K47/48215 , A61K47/488 , A61K47/60 , A61K47/6907 , A61K49/0032 , A61K49/0082 , B82Y5/00
摘要： The present invention provides a nanocarrier having an interior and an exterior, the nanocarrier comprising at least one conjugate, wherein each conjugate includes a polyethylene glycol (PEG) polymer. Each conjugate also includes at least two amphiphilic compounds having both a hydrophilic face and a hydrophobic face. In addition, each conjugate includes an oligomer, wherein at least 2 of the amphiphilic compounds are covalently attached to the oligomer which is covalently attached to the PEG. The nanocarrier is such that each conjugate self-assembles in an aqueous solvent to form the nanocarrier such that a hydrophobic pocket is formed in the interior of the nanocarrier by the orientation of the hydrophobic face of each amphiphilic compound towards each other, and wherein the PEG of each conjugate self-assembles on the exterior of the nanocarrier.
摘要翻译： 本发明提供具有内部和外部的纳米载体，所述纳米载体包含至少一种缀合物，其中每个缀合物包括聚乙二醇（PEG）聚合物。 每个缀合物还包括具有亲水面和疏水性面两者的至少两种两亲性化合物。 此外，每个缀合物包括低聚物，其中至少两个两亲化合物共价连接到共价连接到PEG的低聚物。 纳米载体使得每个缀合物在水性溶剂中自组装形成纳米载体，使得通过每个两亲性化合物的疏水性面向彼此的取向在纳米载体的内部形成疏水性口袋，并且其中PEG 的每个缀合物自组装在纳米载体的外部。
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公开(公告)号：US20110144281A1
公开(公告)日：2011-06-16
申请号：US12746479
申请日：2008-12-05
申请人： Xiao-Xia Zhu , Juntao Luo , Guillaume Giguere
发明人： Xiao-Xia Zhu , Juntao Luo , Guillaume Giguere
IPC分类号： C08F8/06 , C07J9/00 , C07J41/00 , C07K16/00 , C07K14/505 , C07K14/485 , C07K14/62 , C07H7/02 , C07D475/04
CPC分类号： C08G65/2612 , A61K9/1075 , C08G65/2648 , C08G65/30 , C08G65/3322 , C08G65/33306 , C08G65/33327 , C08G65/3342 , C08L2203/02
摘要： The present invention relates to a polymer comprising a cholane core having at least one derivatizable group covalently bonded thereto and a hydrophilic polymer chain covalently bonded to derivatizable group(s) and a process for producing it The present invention also relates to micellar aggregate formed from the polymer of the present.
摘要翻译： 本发明涉及一种聚合物，其包含具有至少一个共价键合的可衍生基团的胆碱核心和共价键合至可衍生基团的亲水性聚合物链及其制备方法本发明还涉及由 本发明的聚合物。
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公开(公告)号：US20100038297A1
公开(公告)日：2010-02-18
申请号：US12308223
申请日：2007-06-14
CPC分类号： C07D403/12 , A61K9/1635 , A61K47/32 , C08F8/18 , C08F8/34 , C08F261/04 , C08F2438/02 , C08F2810/20 , Y10T428/24802 , C08F16/06
摘要： There are provided poly(vinyl alcohol) polymers and copolymers containing vinyl alcohol or vinyl acetate and derivatives thereof such as poly(ethylene glycol)-grafted poly(vinyl alcohol) polymers or polyether-grafted poly(vinyl alcohol) polymers. These polymers can contain various functional groups. Such polymers can be use as polymer matrix or solid support for various chemical substrates such as organic substrates and reagents. Cross-linked poly(vinyl alcohol) polymers and copolymers are also provided. Methods for preparing such polymers as well as several of their uses are also included.
摘要翻译： 提供含有乙烯醇或乙酸乙烯酯及其衍生物如聚（乙二醇）接枝聚（乙烯醇）聚合物或聚醚接枝的聚（乙烯醇））聚合物的聚（乙烯醇）聚合物和共聚物。 这些聚合物可以含有各种官能团。 这样的聚合物可以用作各种化学底物如有机底物和试剂的聚合物基质或固体载体。 还提供交联聚（乙烯醇）聚合物和共聚物。 还包括制备这种聚合物的方法以及它们的几种用途。
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公开(公告)号：US08198364B2
公开(公告)日：2012-06-12
申请号：US12308223
申请日：2007-06-14
IPC分类号： C08F16/06 , C08F290/04 , C08G63/48 , C08F8/00
CPC分类号： C07D403/12 , A61K9/1635 , A61K47/32 , C08F8/18 , C08F8/34 , C08F261/04 , C08F2438/02 , C08F2810/20 , Y10T428/24802 , C08F16/06
摘要： There are provided poly(vinyl alcohol) polymers and copolymers containing vinyl alcohol or vinyl acetate and derivatives thereof such as poly(ethylene glycol)-grafted poly(vinyl alcohol) polymers or polyether-grafted poly(vinyl alcohol) polymers. These polymers can contain various functional groups. Such polymers can be use as polymer matrix or solid support for various chemical substrates such as organic substrates and reagents. Cross-linked poly(vinyl alcohol) polymers and copolymers are also provided. Methods for preparing such polymers as well as several of their uses are also included.
摘要翻译： 提供含有乙烯醇或乙酸乙烯酯及其衍生物如聚（乙二醇）接枝聚（乙烯醇）聚合物或聚醚接枝的聚（乙烯醇））聚合物的聚（乙烯醇）聚合物和共聚物。 这些聚合物可以含有各种官能团。 这样的聚合物可以用作各种化学底物如有机底物和试剂的聚合物基质或固体载体。 还提供交联聚（乙烯醇）聚合物和共聚物。 还包括制备这种聚合物的方法以及它们的几种用途。
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