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14 条记录 (耗时 0.024 秒)

    CHIMERIC ANTIGEN AND T CELL RECEPTORS AND METHODS OF USE
    1.
    发明申请
    CHIMERIC ANTIGEN AND T CELL RECEPTORS AND METHODS OF USE 审中-公开

    公开(公告)号：US20200246382A1

    公开(公告)日：2020-08-06

    申请号：US16711180

    申请日：2019-12-11

    申请人： Kite Pharma, Inc.

    发明人： Arianne Perez ,  Stuart A. Sievers ,  Ruben Alvarez Rodriguez ,  Jonathan Belk

    IPC分类号： A61K35/17 ,  C07K16/28 ,  A61P35/00

    摘要： Provided is a chimeric antigen receptor (CAR) or a T cell receptor (TCR) comprising one or more of the antigen binding motifs disclosed herein. Aspects of the disclosure relate to a polynucleotide encoding a chimeric antigen receptor (CAR) or a T cell receptor (TCR) comprising one or more of the antigen binding motifs. Provided are antibodies and antigen binding systems that comprise a binding motif that binds CD20 and optionally a binding motif that binds CD19, and methods of producing and using the same. Antibodies and antigen binding systems of the present disclosure comprise CARs that comprise an anti-CD20 binding motif and an anti-CD19 binding motif. Provided are compositions, such as antibodies and CARs that are or comprise an anti-CD20/anti-CD19 antigen binding system of the present disclosure, and cell therapies comprising the same, are useful, e.g., in the treatment of cancer.

    MODIFIED CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE
    2.
    发明申请
    MODIFIED CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE 审中-公开

    公开(公告)号：US20190144515A1

    公开(公告)日：2019-05-16

    申请号：US16192492

    申请日：2018-11-15

    申请人： Kite Pharma, Inc.

    发明人： Stuart A. Sievers ,  Jed J. W. Wiltzius

    IPC分类号： C07K14/47 ,  C12N15/62

    摘要： The disclosure provides a chimeric antigen receptor (CAR) comprising a modified hinge, transmembrane and/or intracellular domain disclosed herein. Some aspects of the disclosure relate to a polynucleotide encoding a chimeric antigen receptor (CAR) comprising the costimulatory domain disclosed herein. Other aspects of the disclosure relate to cells comprising the CAR and use in a T cell therapy.

    CHIMERIC POLYPEPTIDES AND USES THEREOF
    8.
    发明申请
    CHIMERIC POLYPEPTIDES AND USES THEREOF 审中-公开

    公开(公告)号：US20190092818A1

    公开(公告)日：2019-03-28

    申请号：US16138331

    申请日：2018-09-21

    申请人： Kite Pharma, Inc.

    发明人： Jed J.W. Wiltzius ,  Stuart A. Sievers

    IPC分类号： C07K14/00 ,  C12N15/85 ,  C12N15/62 ,  C07K4/00 ,  C07K7/06 ,  C07K7/08

    摘要： The invention provides novel peptides (e.g., linkers) and polypeptide compositions comprising the linkers (e.g., fusion proteins) and methods of using the polypeptide compositions. Peptides (e.g., linkers) are useful as tags and for engineering fusion proteins (e.g., antigen binding molecules, scFv). Polypeptide linkers described herein facilitate flexibility of linked peptides allowing for proper folding, conformation and reduced immunogenicity.

    CHIMERIC ANTIGEN RECEPTORS FOR MELANOMA AND USES THEREOF
    9.
    发明申请
    CHIMERIC ANTIGEN RECEPTORS FOR MELANOMA AND USES THEREOF 审中-公开

    公开(公告)号：US20180280437A1

    公开(公告)日：2018-10-04

    申请号：US15919408

    申请日：2018-03-13

    申请人： KITE PHARMA, INC.

    发明人： Jed J.W. Wiltzius ,  Stuart A. Sievers

    IPC分类号： A61K35/17 ,  A61K39/00 ,  A61P35/00

    摘要： The present invention relates to Chimeric Antigen Receptors (CARs) comprising antigen binding domains that specifically bind melanoma cells, polynucleotides encoding such CARs, and vectors comprising such polynucleotides. The present invention further relates to engineered cells comprising such polynucleotides and/or transduced with such viral vectors, and compositions including a plurality of engineered T cells. The present invention also relates to methods for manufacturing such engineered T cells and compositions and uses in treating a melanoma such engineered T cells and compositions.