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公开(公告)号：US5120719A
公开(公告)日：1992-06-09
申请号：US437463
申请日：1989-11-15
IPC分类号： C08B31/04 , A61K31/557 , A61K31/715 , A61K47/48 , A61P43/00 , C07C405/00 , C08B37/00
CPC分类号： A61K47/4823 , A61K31/557
摘要： A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2, prostaglandin F2.alpha., prostaglandin I2, carbacycline and iloprost and the polysaccharide is selected from pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.
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2.发明授权
公开(公告)号：US5425943A
公开(公告)日：1995-06-20
申请号：US900796
申请日：1992-06-22
CPC分类号： A61K9/0019 , A61K38/49 , A61K47/183
摘要： An injection composition comprises a pharmacologically effective amount of a modified tPA, 47.5 mM or more of an amino acid or a salt thereof and is improved in view of stability and solubility.
摘要翻译： 注射组合物包含药理学上有效量的修饰的tPA，47.5mM或更多的氨基酸或其盐，并且从稳定性和溶解性的观点来看是有改进的。
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公开(公告)号：US20070276008A1
公开(公告)日：2007-11-29
申请号：US11703502
申请日：2007-02-06
申请人： James McShane , Ray Wood , Sumio Watanabe , Kiyoshi Iwamoto , Katsumi Onai
发明人： James McShane , Ray Wood , Sumio Watanabe , Kiyoshi Iwamoto , Katsumi Onai
IPC分类号： A61K31/4439 , A61P1/04
CPC分类号： A61K31/4439 , A61K9/0019 , A61K47/02 , A61K47/183 , A61K47/26
摘要： The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5° C.
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公开(公告)号：US07230014B1
公开(公告)日：2007-06-12
申请号：US09549858
申请日：2000-04-14
申请人： James McShane , Ray Wood , Sumio Watanabe , Kiyoshi Iwamoto , Katsumi Onai
发明人： James McShane , Ray Wood , Sumio Watanabe , Kiyoshi Iwamoto , Katsumi Onai
IPC分类号： A61K31/44
CPC分类号： A61K31/4439 , A61K9/0019 , A61K47/02 , A61K47/183 , A61K47/26
摘要： The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The solutions are brought to a pH of between about 9 and about 12, preferably between about pH 10 and 11, by a glycine-sodium hydroxide buffer. Such formulations are chemically and physically stable, and do not significantly change color, for at least between about 6 and about 12 hours at room temperature, and are stable to color change for from between about 24 and 48 hours if kept at 5° C.
摘要翻译： 本发明提供适用于静脉注射的药物制剂，其包含在适于静脉内给药的等渗溶液中重新配制的冻干抗溃疡剂，例如5％右旋糖或0.9％氯化钠。 通过甘氨酸 - 氢氧化钠缓冲液使溶液达到约9至约12，优选约pH 10至11的pH。 这样的制剂在化学和物理上是稳定的，并且在室温下不会显着改变颜色至少约6小时至约12小时，并且如果保持在5℃下稳定的颜色变化约24至48小时。
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5.发明授权Injections containing lipid a analogues and process for the preparation thereof 失效含有脂质类似物的注射剂及其制备方法公开(公告)号：US06235724B1
公开(公告)日：2001-05-22
申请号：US09194704
申请日：1998-12-18
申请人： Yasuyuki Asai , Katsumi Onai , Kazuhide Ashizawa , Kiyoshi Iwamoto , Yasuo Ishibashi , Sumio Watanabe
发明人： Yasuyuki Asai , Katsumi Onai , Kazuhide Ashizawa , Kiyoshi Iwamoto , Yasuo Ishibashi , Sumio Watanabe
IPC分类号： A61K3170
CPC分类号： A61K31/7024 , A61K9/0019 , A61K9/19 , A61K31/7032 , A61K47/02 , Y10S514/951
摘要： The present invention provides a preparation for injection containing a lipid A analog and a process for preparing the same. A preparation for injection prepared by dissolving a lipid A analog or a pharmacologically acceptable salt thereof in an alkaline aqueous solution, at an elevated temperature if necessary, and then adding a buffer thereto, and a process for preparing the same.
摘要翻译： 本发明提供了含有脂质A类似物的注射剂及其制备方法。 根据需要，在升高的温度下将脂质A类似物或其药理学可接受的盐溶解在碱性水溶液中，然后向其中加入缓冲剂制备的注射剂及其制备方法。
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公开(公告)号：US5030455A
公开(公告)日：1991-07-09
申请号：US396838
申请日：1989-08-22
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/135 , A61K31/52 , A61K31/55 , A61K47/00 , A61K47/14 , A61K47/26 , A61K47/44
CPC分类号： A61K9/2013 , A61K47/44
摘要： A sustained-release drug preparation comprises a water-soluble drug, a lipidic substance and an oil as its essential components. The drug level in the blood is sustained at a preferable concentation for a long period of time.
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公开(公告)号：US5576021A
公开(公告)日：1996-11-19
申请号：US275240
申请日：1994-07-15
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K31/551
CPC分类号： A61K9/2081 , A61K31/551 , Y10S514/96 , Y10S514/961 , Y10S514/965
摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains an active substance, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the active substance. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the variability in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.
摘要翻译： 通过压缩含有活性物质的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。 预先用制剂佐剂层和/或制剂佐剂和活性物质的混合物层预先涂覆每种颗粒。 片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物的吸收变化最小化以达到最大生物利用度。
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公开(公告)号：US5093200A
公开(公告)日：1992-03-03
申请号：US253367
申请日：1988-09-30
申请人： Sumio Watanabe , Ichiro Yamakawa , Hidenobu Ando , Nobutaka Noda , Yasuo Miyake
发明人： Sumio Watanabe , Ichiro Yamakawa , Hidenobu Ando , Nobutaka Noda , Yasuo Miyake
CPC分类号： A61K9/5078 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： A multilayer granule of the invention comprises a core, a slow-release layer, a rapid-release layer to be provided outer of said slow-release layer and a film layer containing a metal stearate and being deposited between the slow-release layer and the rapid-release layer. A pharmacologically effective component is kept to discharge for long.
摘要翻译： 本发明的多层颗粒包括芯，缓释层，提供在所述缓释层外部的快速释放层和含有金属硬脂酸盐的膜层，并沉积在缓释层和缓释层之间 快速释放层。 药理学有效成分长时间保持放电。
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公开(公告)号：US5624683A
公开(公告)日：1997-04-29
申请号：US192603
申请日：1994-02-07
申请人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
发明人： Hidenobu Andoh , Sumio Watanabe , Yasuo Miyake
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K31/551
CPC分类号： A61K9/2081 , A61K31/551 , Y10S514/96 , Y10S514/961 , Y10S514/965
摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains a basis, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the basis. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the inbalance in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.
摘要翻译： 通过压缩含有基础的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。 预先将各颗粒剂用制剂佐剂层和/或制剂佐剂和基质的混合物层进行包衣。 片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物吸收的不平衡被最小化以达到最大生物利用度。
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公开(公告)号：US4844905A
公开(公告)日：1989-07-04
申请号：US13832
申请日：1987-02-12
申请人： Masaki Ichikawa , Sumio Watanabe , Yasuo Miyake
发明人： Masaki Ichikawa , Sumio Watanabe , Yasuo Miyake
CPC分类号： A61K9/0065 , A61K9/0007 , A61K9/5073 , A61K9/5078
摘要： A granule of drug to remain in the stomach comprises a core comprising a pharmaceutically effective ingredient, a foaming layer coated on said core and an expansive film coated on said layer.
摘要翻译： 保留在胃中的药物颗粒包括包含药学有效成分的核心，涂覆在所述核心上的发泡层和涂覆在所述层上的膨胀膜。
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