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    Sustained-release multi-granule tablet
    2.
    发明授权
    Sustained-release multi-granule tablet 失效
    持续释放多颗粒片剂

    公开(公告)号：US5624683A

    公开(公告)日：1997-04-29

    申请号：US192603

    申请日：1994-02-07

    申请人： Hidenobu Andoh ,  Sumio Watanabe ,  Yasuo Miyake

    发明人： Hidenobu Andoh ,  Sumio Watanabe ,  Yasuo Miyake

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K31/551

    CPC分类号： A61K9/2081 ,  A61K31/551 ,  Y10S514/96 ,  Y10S514/961 ,  Y10S514/965

    摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains a basis, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the basis. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the inbalance in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.

    摘要翻译： 通过压缩含有基础的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。 预先将各颗粒剂用制剂佐剂层和/或制剂佐剂和基质的混合物层进行包衣。 片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物吸收的不平衡被最小化以达到最大生物利用度。

    Sustained-release multi-granule tablet
    4.
    发明授权
    Sustained-release multi-granule tablet 失效
    持续释放多颗粒片剂

    公开(公告)号：US5576021A

    公开(公告)日：1996-11-19

    申请号：US275240

    申请日：1994-07-15

    申请人： Hidenobu Andoh ,  Sumio Watanabe ,  Yasuo Miyake

    发明人： Hidenobu Andoh ,  Sumio Watanabe ,  Yasuo Miyake

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K31/551

    CPC分类号： A61K9/2081 ,  A61K31/551 ,  Y10S514/96 ,  Y10S514/961 ,  Y10S514/965

    摘要： A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains an active substance, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the active substance. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the variability in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.

    摘要翻译： 通过压缩含有活性物质的缓释颗粒和制剂佐剂获得缓释多颗粒片剂。 预先用制剂佐剂层和/或制剂佐剂和活性物质的混合物层预先涂覆每种颗粒。 片剂以适当的速度将活性物质释放到消化道中，导致每个患者和个体患者中药物的吸收变化最小化以达到最大生物利用度。

    Fuel cell system
    9.
    发明授权
    Fuel cell system 有权
    燃料电池系统

    公开(公告)号：US06503650B1

    公开(公告)日：2003-01-07

    申请号：US09607119

    申请日：2000-06-29

    申请人： Takashi Yasuo ,  Yasuo Miyake

    发明人： Takashi Yasuo ,  Yasuo Miyake

    IPC分类号： H01M804

    CPC分类号： H01M8/04291 ,  H01M8/04156 ,  H01M8/2485

    摘要： A fuel cell system, comprising: (A) a cell multilayer element that is formed by stacking unit cell structures in layers, a unit cell structure including: a cell that includes a cathode, an anode, and electrolyte sandwiched between the cathode and the anode an oxidant channel unit with a plurality of oxidant channels that cross the cathode and enable oxidant to be supplied to the cathode; and a fuel channel unit with a plurality of fuel channels that cross the anode and enables fuel to be supplied to the anode; (B) oxidant supplying means for supplying the oxidant to the oxidant channels; and (C) fuel supplying means for supplying the fuel to the fuel channels, wherein the oxidant supplying means includes first switching means for reversing a flow direction of the oxidant in at least one of the oxidant channels and/or the fuel supplying means includes second switching means for reversing a flow direction of the fuel in at least one of the fuel channels.

    摘要翻译： 一种燃料电池系统，包括：（A）通过层叠单元电池结构形成的电池多层元件，单元电池结构，包括：包含阴极，阳极和夹在所述阴极和所述阳极之间的电解质的电池 具有多个氧化剂通道的氧化剂通道单元，所述氧化剂通道穿过阴极并使氧化剂能够供应到阴极; 以及具有多个燃料通道的燃料通道单元，所述多个燃料通道穿过所述阳极并且能够将燃料供应到所述阳极; （B）用于将氧化剂供给到氧化剂通道的氧化剂供给装置; 和（C）用于向燃料通道供应燃料的燃料供应装置，其中氧化剂供给装置包括用于反转至少一个氧化剂通道和/或燃料供给装置中的氧化剂的流动方向的第一切换装置，包括第二 用于使至少一个燃料通道中的燃料的流动方向反转的切换装置。

    Fuel cell having water permeability adjustment capability
    10.
    发明授权
    Fuel cell having water permeability adjustment capability 有权
    具有透水性调节能力的燃料电池

    公开(公告)号：US06365293B1

    公开(公告)日：2002-04-02

    申请号：US09599198

    申请日：2000-06-22

    申请人： Takahiro Isono ,  Yasuo Miyake ,  Akira Hamada ,  Minoru Kaneko ,  Kunihiro Nakato

    发明人： Takahiro Isono ,  Yasuo Miyake ,  Akira Hamada ,  Minoru Kaneko ,  Kunihiro Nakato

    IPC分类号： H01M810

    CPC分类号： H01M8/04291 ,  H01M8/1007

    摘要： The object of the present invention is to provide fuel cell including a cell that is formed by sandwiching solid polymer membrane between an anode and a cathode that generates electricity with stability and high performance by evenly moistening the solid polymer membrane. For this purpose, in a gas diffusion layer 24, which is positioned adjacent to a cathode catalyst layer 22, the content of fluororesin in an area on the side of the entrance for the oxidizer is set to be higher than in another area on the side of the exit so that the water repellency in the entrance side area is higher than in the exit side area. As a result, a water permeation suppressing part 24A, where the water permeability is relatively low, is formed in the area on the entrance side, while a water permeable part 24B, where the water permeability is relatively high, is formed in the area on the exit side.

    摘要翻译： 本发明的目的是提供一种燃料电池，其包括通过将固体聚合物膜夹在阳极和阴极之间而形成的电池，其通过均匀润湿固体聚合物膜而稳定且高性能地发电。 为此，在与阴极催化剂层22相邻的气体扩散层24中，氧化剂入口侧的区域中的氟树脂的含量设定为高于侧面的其他区域 使得入口侧区域中的防水性高于出口侧区域。 结果，在入口侧的区域中形成透水性相对较低的透水抑制部24A，而在透水性相对较高的水分透过部24B形成在 出口侧。