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公开(公告)号:US5140046A
公开(公告)日:1992-08-18
申请号:US567159
申请日:1990-08-13
申请人: Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
发明人: Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
IPC分类号: A61K31/195 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07C233/81 , C07C235/56 , C07C235/64 , C07C255/60 , C07C271/28 , C07C275/40 , C07D257/04 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号: C07D257/04 , C07C235/56 , C07C235/64 , C07C255/00 , C07C255/60 , C07C271/28 , C07C275/40 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07D285/125 , C07D285/135
摘要: Novel phenylene derivatives shown by the general formula ##STR1## where A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, B represents ##STR2## wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A(slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.
摘要翻译: 其中A表示氢原子,苯基或苯氧基,n表示3〜10的整数,R 1表示氢原子或低级烷氧基,X 1表示-CH 2 CH 2的通式[IMAGE]所示的新型亚苯基衍生物 - , - CH = CH-,-CONH-,+ E,crc / B /表示其中R2表示氢原子,卤素原子,硝基等),其中R3表示 氢原子,羟基或低级烷氧基),X2表示-CH = CH-,-CH2CH2-等,D表示可用作药物的羧基,低级烷氧基羰基或“IMAGE”,特别是SRS -A(过敏反应缓慢反应物质)拮抗剂,即可用作预防和治疗由SRS-A引起的各种过敏性疾病(如支气管哮喘,过敏性鼻炎,荨麻疹)或缺血性心脏病,炎症等。
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公开(公告)号:US4994479A
公开(公告)日:1991-02-19
申请号:US899218
申请日:1986-08-15
申请人: Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
发明人: Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
IPC分类号: A61K31/195 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C59/90 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07C233/12 , C07C235/56 , C07C235/64 , C07C255/59 , C07C255/60 , C07C271/28 , C07C275/40 , C07D257/04 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号: C07D257/04 , C07C235/56 , C07C235/64 , C07C255/00 , C07C255/60 , C07C271/28 , C07C275/40 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07D285/125 , C07D285/135
摘要: Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, .circle.B represents ##STR2## (wherein R.sub.2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.
摘要翻译: PCT No.PCT / JP86 / 00155 Sec。 371日期1986年8月15日 102(e)日期1986年8月15日PCT提交1986年3月31日PCT公布。 公开号WO86 / 05779 日期:1986年10月9日。通式[IMAGE]所示的新型亚苯基衍生物,其中A表示氢原子,苯基或苯氧基,n表示3〜10的整数,R1表示氢原子或低级 烷氧基,X 1表示-CH 2 CH 2 - , - CH = CH - , - CONH - ,&C&B表示< IMAGE>(其中R 2表示氢原子,卤素原子,硝基等), R3表示氢原子,羟基或低级烷氧基),X2表示-CH = CH-,-CH2CH2-等,D表示可用作药物的羧基,低级烷氧基羰基或
特别是SRS-A(过敏反应缓慢反应物质)拮抗剂,即它们可用作预防和治疗SRS-诱导的各种过敏性疾病(如支气管哮喘,过敏性鼻炎,荨麻疹)或缺血性心脏病,炎症等。 一个。 -
公开(公告)号:US5180730A
公开(公告)日:1993-01-19
申请号:US682867
申请日:1991-04-05
申请人: Toshiyasu Mase , Ryuji Tsuzuki , Hiromu Hara , Kiyoshi Murase , Kenichi Tomioka
发明人: Toshiyasu Mase , Ryuji Tsuzuki , Hiromu Hara , Kiyoshi Murase , Kenichi Tomioka
IPC分类号: C07D213/70 , C07D239/56 , C07D249/12 , C07D275/02 , C07D275/03 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号: C07D213/70 , C07D239/56 , C07D249/12 , C07D275/03 , C07D285/125 , C07D285/135
摘要: This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S--directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).
摘要翻译: 本发明涉及结构上特征在于含有特定杂环基和与特定杂环基直接结合的-CH 2 -S-存在的新型杂环化合物。 这些杂环化合物可用作药物,特别是作为SRS-A的拮抗剂(过敏反应缓慢反应物质)。
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公开(公告)号:US5116853A
公开(公告)日:1992-05-26
申请号:US413458
申请日:1989-09-27
申请人: Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
发明人: Toshiyasu Mase , Kiyoshi Murase , Hiromu Hara , Kenichi Tomioka
IPC分类号: A61K31/195 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C59/90 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07C233/12 , C07C235/56 , C07C235/64 , C07C255/59 , C07C255/60 , C07C271/28 , C07C275/40 , C07D257/04 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号: C07D257/04 , C07C235/56 , C07C235/64 , C07C255/00 , C07C255/60 , C07C271/28 , C07C275/40 , C07C45/71 , C07C47/575 , C07C59/70 , C07C59/72 , C07C65/21 , C07C65/24 , C07C69/712 , C07C69/734 , C07D285/125 , C07D285/135
摘要: Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R.sub.1 represents a hydrogen atom or a lower alkoxy group, X.sub.1 represents --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CONH--, B represents ##STR2## (wherein R.sub.2 represents a hydrogen atom, a halogen, atom, a nitro group, etc.), ##STR3## (wherein R.sub.3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X.sub.2 represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or ##STR4## which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.
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公开(公告)号:US4803211A
公开(公告)日:1989-02-07
申请号:US885085
申请日:1986-07-14
申请人: Toshiyasu Mase , Ryuji Tsuzuki , Hiromu Hara , Kiyoshi Murase , Kenichi Tomioka
发明人: Toshiyasu Mase , Ryuji Tsuzuki , Hiromu Hara , Kiyoshi Murase , Kenichi Tomioka
IPC分类号: C07D213/70 , C07D239/56 , C07D249/12 , C07D275/02 , C07D275/03 , C07D285/12 , C07D285/125 , C07D285/135 , A61K31/41
CPC分类号: C07D213/70 , C07D239/56 , C07D249/12 , C07D275/03 , C07D285/125 , C07D285/135
摘要: This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S-- directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).
摘要翻译: 本发明涉及结构特征在于含有特定杂环基并通过与特定杂环基直接结合的-CH 2 -S-的存在的新型杂环化合物。 这些杂环化合物可用作药物,特别是作为SRS-A的拮抗剂(过敏反应缓慢反应物质)。
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公开(公告)号:US5177215A
公开(公告)日:1993-01-05
申请号:US486550
申请日:1990-02-28
申请人: Kiyoshi Murase , Toshiyasu Mase , Hiromu Hara , Kenichi Tomioka
发明人: Kiyoshi Murase , Toshiyasu Mase , Hiromu Hara , Kenichi Tomioka
IPC分类号: B01L3/14 , C07D239/58 , C07D249/04 , C07D249/12 , C07D249/14 , C07D275/02 , C07D275/03 , C07D277/16 , C07D277/74 , C07D285/12 , C07D285/125 , C07D285/135 , C07D309/40
CPC分类号: C07D275/03 , B01L3/5082 , C07D239/58 , C07D249/04 , C07D249/14 , C07D277/16 , C07D277/74 , C07D285/125 , C07D285/135 , C07D309/40
摘要: Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A).
摘要翻译: 通式[IMAGE]所示的新型杂环化合物或其药学上可接受的盐特别是作为缓释反应物质的过敏反应的拮抗剂(SRS-A)有用。
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公开(公告)号:US4933348A
公开(公告)日:1990-06-12
申请号:US228542
申请日:1988-08-04
申请人: Toshiyasu Mase , Ryuji Tsuzuki , Hiromu Hara , Kiyoshi Murase , Kenichi Tomioka
发明人: Toshiyasu Mase , Ryuji Tsuzuki , Hiromu Hara , Kiyoshi Murase , Kenichi Tomioka
IPC分类号: C07D213/70 , C07D239/56 , C07D249/12 , C07D275/02 , C07D275/03 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号: C07D213/70 , C07D239/56 , C07D249/12 , C07D275/03 , C07D285/125 , C07D285/135
摘要: This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH.sub.2 --S-- directly bound to the specific heterocyclic group. These heterocyclic compounds are useful as medicines, particularly as antagonists of SRS-A (slow reacting substance of anaphylaxis).
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公开(公告)号:US4908368A
公开(公告)日:1990-03-13
申请号:US362959
申请日:1989-06-07
申请人: Kiyoshi Murase , Toshiyasu Mase , Hiromu Hara , Kenichi Tomioka
发明人: Kiyoshi Murase , Toshiyasu Mase , Hiromu Hara , Kenichi Tomioka
IPC分类号: C07D285/12 , A61K31/41 , A61K31/425 , A61K31/505 , C07D239/58 , C07D249/04 , C07D249/12 , C07D249/14 , C07D275/02 , C07D275/03 , C07D277/16 , C07D277/74 , C07D285/125 , C07D285/135 , C07D309/40
CPC分类号: C07D275/03 , C07D239/58 , C07D249/04 , C07D249/14 , C07D277/16 , C07D277/74 , C07D285/125 , C07D285/135 , C07D309/40
摘要: Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis(SRS-A).
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公开(公告)号:US4855310A
公开(公告)日:1989-08-08
申请号:US173734
申请日:1988-03-25
申请人: Kiyoshi Murase , Toshiyasu Mase , Hiromu Hara , Kenichi Tomioka
发明人: Kiyoshi Murase , Toshiyasu Mase , Hiromu Hara , Kenichi Tomioka
IPC分类号: C07D285/12 , A61K31/41 , A61K31/425 , A61K31/505 , C07D239/58 , C07D249/04 , C07D249/12 , C07D249/14 , C07D275/02 , C07D275/03 , C07D277/16 , C07D277/74 , C07D285/125 , C07D285/135 , C07D309/40
CPC分类号: C07D275/03 , C07D239/58 , C07D249/04 , C07D249/14 , C07D277/16 , C07D277/74 , C07D285/125 , C07D285/135 , C07D309/40
摘要: Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A).
摘要翻译: 通式[IMAGE]所示的新型杂环化合物或其药学上可接受的盐特别是作为缓释反应物质的过敏反应物质(SRS-A)的拮抗剂。
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公开(公告)号:US4987132A
公开(公告)日:1991-01-22
申请号:US232899
申请日:1988-08-16
申请人: Toshiyasu Mase , Hiromu Hara , Hitoshi Nagaoka , Takumi Takahashi , Takeshi Suzuki , Kenichi Tomioka , Toshimitsu Yamada
发明人: Toshiyasu Mase , Hiromu Hara , Hitoshi Nagaoka , Takumi Takahashi , Takeshi Suzuki , Kenichi Tomioka , Toshimitsu Yamada
IPC分类号: C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/14
CPC分类号: C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/14
摘要: A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. ##STR1##
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