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1.发明申请Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法公开(公告)号：US20060040928A1
公开(公告)日：2006-02-23
申请号：US11132815
申请日：2005-05-19
申请人： Klaus Bornemann , Guenter Trummlitz , Edward Lazer , Clara Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Edward Lazer , Clara Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： C07D279/16 , A61K31/5415
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译： 治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。
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2.发明申请Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法公开(公告)号：US20080139541A1
公开(公告)日：2008-06-12
申请号：US12015735
申请日：2008-01-17
申请人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： A61K31/542 , A61P25/28
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid D peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译： 治疗或预防与淀粉样蛋白β肽（Abeta）的异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或与含有淀粉样蛋白D肽的斑块形成（ Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。
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3.发明授权Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法公开(公告)号：US07534787B2
公开(公告)日：2009-05-19
申请号：US12015735
申请日：2008-01-17
申请人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译： 治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3，R 5，R 6，L 1和i如权利要求1中所定义。
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4.发明授权Method of treating diseases and conditions associated with an altered level of amyloid β peptides and new enolcarboxamide compounds 有权治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法公开(公告)号：US07375220B2
公开(公告)日：2008-05-20
申请号：US11132815
申请日：2005-05-19
申请人： Klaus Bornemann , Guenter Trummlitz , Edward S. Lazer , Clara K. Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Edward S. Lazer , Clara K. Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： C07D279/16 , A61K31/5415
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译： 治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。
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5.发明申请Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法公开(公告)号：US20050277635A1
公开(公告)日：2005-12-15
申请号：US11132482
申请日：2005-05-19
申请人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： A61K31/541 , C07D279/02 , C07D513/04 , A61K31/54
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译： 治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。
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6.发明申请Substituted Ethane-1,2-Diamines for the Treatment of Alzheimer's Disease II 审中-公开用于治疗阿尔茨海默病的取代乙烷-1,2-二胺Ⅱ公开(公告)号：US20080293680A1
公开(公告)日：2008-11-27
申请号：US11997449
申请日：2006-08-01
申请人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Herbert Nar , Klaus Bornemann , Klaus Klinder , Margit Bauer
发明人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Herbert Nar , Klaus Bornemann , Klaus Klinder , Margit Bauer
IPC分类号： A61K31/65 , C07D213/02 , A61K31/44 , C07C229/02 , A61K31/19 , C07C237/00 , A61K31/164 , C12N9/99 , A61P25/00 , C07D401/02 , A61K31/4439 , A61K31/355 , A61K31/445 , A61K31/473 , A61K31/55
CPC分类号： C07K5/0207 , A61K38/03 , C07K5/021 , A61K2300/00
摘要： The invention relates to a compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如说明书和权利要求中所定义，以及其用于治疗或预防阿尔茨海默病和其它类似物 疾病
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7.发明申请Substituted ethane-1,2-diamines for the treatment of Alzheimer's disease 审中-公开用于治疗阿尔茨海默氏病的取代的乙烷-1,2-二胺公开(公告)号：US20060025345A1
公开(公告)日：2006-02-02
申请号：US11133948
申请日：2005-05-20
申请人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Margit Bauer , Herbert Nar , Klaus Bornemann , Klaus Klinder , Joerg Rademann , Steffen Weik
发明人： Stefan Peters , Christian Eickmeier , Klaus Fuchs , Werner Stransky , Cornelia Dorner-Ciossek , Marcus Kostka , Sandra Handschuh , Margit Bauer , Herbert Nar , Klaus Bornemann , Klaus Klinder , Joerg Rademann , Steffen Weik
CPC分类号： C07K7/02 , A61K38/00 , C07C237/06 , C07K5/0207
摘要： The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, A, B, and Y are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7，R 8，R 9， R 10，R 10，R 11，R 12，R 13，A，B和Y是 如说明书和权利要求书中所定义，以及其用于治疗或预防阿尔茨海默病和其他类似疾病的用途。
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公开(公告)号：US20060100158A1
公开(公告)日：2006-05-11
申请号：US11268197
申请日：2005-11-07
申请人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
发明人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
CPC分类号： C07K5/0205 , A61K38/00
摘要： The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7和R 8如本说明书和权利要求书中所定义， 以及其用于治疗或预防阿尔茨海默病和其他类似疾病的用途。
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9.发明申请Substituted 1,2-ethylenediamines, Methods for Preparing Them and Uses Thereof 审中-公开取代的1,2-乙二胺，其制备方法及用途公开(公告)号：US20090325940A1
公开(公告)日：2009-12-31
申请号：US12511474
申请日：2009-07-29
申请人： Christian Eickmeier , Stefan Peters , Klaus Fuchs , Niklas Heine , Sandra Handschuh , Cornelia Dorner-Ciossek , Klaus Klinder , Marcus Kostka
发明人： Christian Eickmeier , Stefan Peters , Klaus Fuchs , Niklas Heine , Sandra Handschuh , Cornelia Dorner-Ciossek , Klaus Klinder , Marcus Kostka
IPC分类号： A61K31/54 , A61K31/535 , A61K31/16 , C07D285/16 , C07D265/32 , C07C237/02
CPC分类号： C07K5/06026 , C07K5/06034 , C07K5/06191 , C07K5/0808 , C07K5/0812 , C07K5/0821
摘要： The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1-X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译： 本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 15，A，B，L，i以及X 1 -X 4如在说明书和权利要求书中所定义，以及其用于 治疗阿尔茨海默病（AD）和类似疾病。
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公开(公告)号：US07238774B2
公开(公告)日：2007-07-03
申请号：US11268197
申请日：2005-11-07
申请人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
发明人： Stefan Peters , Klaus Fuchs , Christian Eickmeier , Werner Stransky , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder , Marcus Kostka
IPC分类号： A61K38/03
CPC分类号： C07K5/0205 , A61K38/00
摘要： The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7和R 8如本说明书和权利要求书中所定义， 以及其用于治疗或预防阿尔茨海默病和其他类似疾病的用途。
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