公开(公告)号：US5244577A

公开(公告)日：1993-09-14

申请号：US7801

申请日：1993-01-22

申请人： Kohei Notoya ,  Keiji Yoshida ,  Iwao Yamazaki

发明人： Kohei Notoya ,  Keiji Yoshida ,  Iwao Yamazaki

IPC分类号： A61L27/36 ,  C07K4/12

CPC分类号： A61L27/3695 ,  A61L27/3608 ,  A61L27/3687 ,  C07K2/00

摘要： A process for preparing an osteogenesis promoting substance, which comprises extracting a demineralized bone powder with a solution of chaotorpic reagent, subjecting the extracted solution to ultrafiltration to collect a fraction containing substances ranging from 1,000 to 100,000 daltons as molecular weight, dialyzing the collected fraction and collecting the water-insoluble fraction from the dialyzing liquid. The osteogenesis promoting substance prepared by the present invention is useful as a bone repairing agent and a bone grafting agent.

摘要翻译： 一种制备成骨促进物质的方法，该方法包括用双酚类试剂溶液提取脱矿质骨粉末，对提取液进行超滤，以分子量收集含有1,000至100,000道尔顿物质的馏分，透析所收集的馏分， 从透析液中收集不溶于水的部分。 通过本发明制备的成骨促进物质可用作骨修复剂和骨移植剂。

公开(公告)号：US06340704B1

公开(公告)日：2002-01-22

申请号：US09341803

申请日：1999-07-19

申请人： Shogo Marui ,  Masatoshi Hazama ,  Kohei Notoya ,  Koki Kato

发明人： Shogo Marui ,  Masatoshi Hazama ,  Kohei Notoya ,  Koki Kato

IPC分类号： A61K31357

CPC分类号： C07D491/04 ,  A61K31/166 ,  A61K31/36 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/496 ,  A61K31/5377 ,  C07D215/48 ,  C07D317/70 ,  C07D401/04 ,  C07D405/04

摘要： The present invention provides a compound represented by the formula: wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which may be substituted or N(O)m (m is 0 or 1); a ring A is a homo- or hetero-cycle which is substituted by a halogen atom, lower alkyl, lower alkoxy or lower alkylenedioxy; and a ring B is a homo- or hetero-cycle which may be substituted; or a salt thereof, which exhibits excellent cell differentiation-inducing action and cell differentiation-inducing factor action-enhancing action, and is useful in the treatment and prevention of various nerve diseases or bone/joint diseases.

摘要翻译： 本发明提供由下式表示的化合物：其中R1是可被取代的氨基; R2是氢原子或可被取代的低级烷基; X是可以被取代的甲炔基或N（O）m（m是0或1）; 环A是被卤素原子，低级烷基，低级烷氧基或低级亚烷基二氧基取代的同 - 或异 - 循环; 并且环B是可被取代的同 - 或异 - 循环; 或其盐，其表现出优异的细胞分化诱导作用和细胞分化诱导因子作用增强作用，并且可用于治疗和预防各种神经疾病或骨/关节疾病。

公开(公告)号：US20090304821A1

公开(公告)日：2009-12-10

申请号：US12224869

申请日：2007-03-07

申请人： Kohei Notoya ,  Masahiro Oka

发明人： Kohei Notoya ,  Masahiro Oka

IPC分类号： A61K33/00 ,  A61K31/519 ,  A61K31/56 ,  A61K31/593 ,  A61P5/00

CPC分类号： A61K45/06 ,  A61K31/519 ,  A61K31/593 ,  C07D487/04 ,  A61K2300/00

摘要： Disclosed is a pharmaceutical combination comprising a calcium receptor modulator and a bone resorption inhibitor, wherein the calcium receptor modulator comprises a compound represented by the formula (I): wherein the ring A represents a 5- to 7-membered ring which may be substituted; the ring B represents a 5- to 7-membered heterocyclic ring which may be substituted; X1 represents CR1 (wherein R1 represents a hydrogen, a hydrocarbon group which may be substituted, or the like) or the like; X2 represents N or the like; Y represents C or the like; Ar represents a cyclic group which may be substituted; R represents a hydrocarbon group which may be substituted, or the like; and represents a single bond or a double bond; or a salt thereof or a prodrug of the compound or the salt.

摘要翻译： 公开了包含钙受体调节剂和骨吸收抑制剂的药物组合，其中所述钙受体调节剂包含由式（I）表示的化合物：其中环A表示可被取代的5-至7-元环; 环B表示可被取代的5-至7-元杂环; X1表示CR1（其中R1表示氢，可被取代的烃基等）等; X2表示N等; Y表示C等; Ar表示可以被取代的环状基团; R表示可被取代的烃基等; ＆lt; img id =“CUSTOM-CHARACTER-00001”he =“2.79mm”wi =“6.35mm”file =“US20090304821A1-20091210-P00001.TIF”img-content =“character”img-format =“tif”/ >表示单键或双键; 或其盐或化合物或其盐的前药。

公开(公告)号：US20050165064A1

公开(公告)日：2005-07-28

申请号：US10512285

申请日：2003-04-24

申请人： Masahiro Kajino ,  Masayuki Takizawa ,  Kohei Notoya ,  Hiroshi Nara ,  Tomomi Ikemoto ,  Atsuko Nishiguchi

发明人： Masahiro Kajino ,  Masayuki Takizawa ,  Kohei Notoya ,  Hiroshi Nara ,  Tomomi Ikemoto ,  Atsuko Nishiguchi

IPC分类号： A61K31/4439 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D401/06 ,  C07D401/14 ,  C07D43/02

CPC分类号： C07D401/14 ,  A61K31/4439 ,  C07D401/06

摘要： The present invention provides a novel thiol derivative [I] which has an excellent matrix metalloprotease inhibiting activity and is useful as a pharmaceutical composition, particularly a therapeutic agent or prophylactic agent for osteoarthritis and rheumatoid arthritis and a salt thereof, the thiol derivative being a compound represented by the formula [I]: wherein ring A represents an optionally substituted aromatic heterocyclic ring; ring B represents an optionally substituted homocyclic or heterocyclic ring; R1 represents a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group, an optionally substituted heterocyclic group or SR2 (wherein R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group); X represents an optionally substituted divalent C1-3 aliphatic hydrocarbon group; Y represents an optionally substituted hydrocarbon group, a halogen atom, a carboxy group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, SR3 (wherein R3 represents a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group), an oxo group, a thioxo group, an optionally substituted imino group, a nitro group or a cyano group; and q represents an integer of 0 to 5.

摘要翻译： 本发明提供一种具有优异的基质金属蛋白酶抑制活性的新型硫醇衍生物[I]，可用作药物组合物，特别是用于骨关节炎和类风湿性关节炎的治疗剂或预防剂及其盐，硫醇衍生物为化合物 由式[I]表示：其中环A表示任选取代的芳族杂环; 环B表示任选取代的杂环或杂环; R 1表示氢原子，任选取代的烃基，酰基，任选取代的杂环基或SR 2（其中R 2， 表示氢原子，任选取代的烃基，酰基或任选取代的杂环基）; X表示任选取代的二价C 1-3脂族烃基; Y表示任选取代的烃基，卤素原子，羧基，酰基，任选取代的羟基，任选取代的氨基，SR 3（其中R 3， SUP>表示氢原子，任选取代的烃基，酰基或任选取代的杂环基），氧代基，硫代基，任选取代的亚氨基，硝基或氰基; q表示0〜5的整数。

公开(公告)号：US20060034832A1

公开(公告)日：2006-02-16

申请号：US10512587

申请日：2003-04-24

申请人： Haruhide Kimura ,  Yoshimi Sato ,  Masayuki Takizawa ,  Takashi Horiguchi ,  Kohei Notoya

发明人： Haruhide Kimura ,  Yoshimi Sato ,  Masayuki Takizawa ,  Takashi Horiguchi ,  Kohei Notoya

IPC分类号： A61K39/395 ,  A61K31/5415

CPC分类号： C07D417/04 ,  A61K31/00 ,  A61K31/5415 ,  C07D279/08 ,  G01N2333/52 ,  G01N2500/02

摘要： The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, traumatic diseases, demyelinating diseases, bone/joint diseases, kidney diseases, liver diseases, myelodysplastic diseases, arteriosclerosis, diabetes, pulmonary hypertension, sepsis, inflammatory bowel diseases, autoimmune diseases, failure accompanying rejection in organ transplantation, AIDS, cancer, etc.

摘要翻译： 包含能够结合巨噬细胞迁移抑制因子的物质的细胞死亡抑制剂可用作例如心脏病，神经变性疾病，脑血管疾病，中枢神经感染，创伤性疾病，脱髓鞘疾病，骨/关节疾病的预防/治疗剂 肾脏疾病，肝脏疾病，骨髓增生异常性疾病，动脉硬化，糖尿病，肺动脉高压，败血症，炎症性肠病，自身免疫疾病，器官移植排斥反应失败，艾滋病，癌症等。

公开(公告)号：US6030967A

公开(公告)日：2000-02-29

申请号：US945631

申请日：1997-10-30

申请人： Shogo Marui ,  Masatoshi Hazama ,  Kohei Notoya ,  Masaki Ogino

发明人： Shogo Marui ,  Masatoshi Hazama ,  Kohei Notoya ,  Masaki Ogino

IPC分类号： A61K31/4035 ,  A61K31/4741 ,  A61K31/4745 ,  C07D209/64 ,  C07D209/66 ,  C07D317/70 ,  C07D401/04 ,  C07D405/04 ,  C07D471/04 ,  C07D491/04 ,  C07D491/056 ,  A61K31/365 ,  A61K31/40 ,  C07D217/24 ,  C07D317/48

CPC分类号： C07D401/04 ,  A61K31/4035 ,  A61K31/4741 ,  A61K31/4745 ,  C07D209/64 ,  C07D209/66 ,  C07D317/70 ,  C07D405/04 ,  C07D471/04 ,  C07D491/04

摘要： A compound of the formula: whereinQ is an optionally substituted carbon atom or N(O)p wherein p is 0 or 1;Y is an optionally substituted methylene group, S(O)q wherein q is an integer of 0 to 2, or an optionally substituted imino group;Z.sup.1 is a C.sub.1-3 alkylene group which may have an oxo group or a thioxo group and may contain etherified oxygen or sulfur within the carbon chain;Z.sup.2 is an optionally substituted C.sub.1-3 alkylene group;Ar is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;one of R.sup.1 and R.sup.2 is a hydrogen atom, a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group;the other is a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group; orR.sup.1 and R.sup.2 taken together with adjacent --c.dbd.c-- form a ring; andring A is a benzene ring which may be substituted in addition to R.sup.1 and R.sup.2 ; or a salt thereof.

摘要翻译： PCT No.PCT / JP97 / 02858 Sec。 371 1997年10月30日第 102（e）1997年10月30日PCT PCT 1997年8月19日PCT公布。 第WO98 / 07705号公报 日期：1998年2月26日一种下式的化合物：其中Q是任选取代的碳原子或N（O）p，其中p是0或1; Y是任选取代的亚甲基，S（O）q，其中q是0-2的整数，或任选取代的亚氨基; Z1是可以具有氧代基或硫代基的C1-3亚烷基，并且可以在碳链内含有醚化的氧或硫; Z2是任选取代的C 1-3亚烷基; Ar是任选取代的碳环基团或任选取代的杂环基团; R 1和R 2中的一个是氢原子，卤素原子，羟基，任选取代的低级烷基或任选取代的低级烷氧基; 另一个是卤素原子，羟基，任意取代的低级烷基或任意取代的低级烷氧基; 或者R 1和R 2与相邻的-c = c-一起形成环; 环A是除R1和R2之外可以被取代的苯环; 或其盐。