公开(公告)号：US20080114003A1

公开(公告)日：2008-05-15

申请号：US11794180

申请日：2005-12-27

申请人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Junya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

发明人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Junya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

IPC分类号： A61K31/506 ,  C07D413/04 ,  A61P29/00 ,  A61P11/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/00

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The invention discloses isoxazole derivatives represented by a formula, in which R1 stands for hydrogen, lower alkyl, amino, halogen, lower alkoxy and the like, R2 stands for substituted or unsubstituted aryl and the like, R3 stands for hydrogen or lower alkyl, R4 stands for substituted or unsubstituted phenyl and the like, and Y stands for —CH2—, —CO—, —CH(CH3)—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof, which have excellent p38MAPkinase inhibitory action.

摘要翻译： 本发明公开了由式表示的异恶唑衍生物，其中R 1代表氢，低级烷基，氨基，卤素，低级烷氧基等，R 2代表取代的 或未取代的芳基等，R 3代表氢或低级烷基，R 4代表取代或未取代的苯基等，Y代表-CH

公开(公告)号：US08207203B2

公开(公告)日：2012-06-26

申请号：US12308875

申请日：2007-06-26

申请人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

发明人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

IPC分类号： A61K31/4439 ,  C07D413/04

CPC分类号： C07D413/04 ,  C07D413/14

摘要： This invention offers isoxazole derivatives represented by the following formula (I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for —CH2—, —CO—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and are useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like.

摘要翻译： 本发明提供由下式（I）表示的异恶唑衍生物，其中R 1和R 2各自代表氢，低级烷基，氨基等; R3代表取代或未取代的芳基或杂芳基; R4代表氢或低级烷基; R5代表取代或未取代的苯基，呋喃基等; Y表示具有优异的p38MAP激酶抑制作用的副产物-CH 2 - ， - CO - ， - O-，-NH-等或其药学上可接受的盐，可用于治疗慢性 类风湿性关节炎，溃疡性结肠炎等。

公开(公告)号：US07939536B2

公开(公告)日：2011-05-10

申请号：US11794180

申请日：2005-12-27

申请人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

发明人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

IPC分类号： C07D413/04 ,  A61K31/506

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The invention discloses isoxazole derivatives represented by a formula, in which R1 stands for hydrogen, lower alkyl, amino, halogen, lower alkoxy and the like, R2 stands for substituted or unsubstituted aryl and the like, R3 stands for hydrogen or lower alkyl, R4 stands for substituted or unsubstituted phenyl and the like, and Y stands for —CH2—, —CO—, —CH(CH3)—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof, which have excellent p38MAPkinase inhibitory action.

摘要翻译： 本发明公开了由式表示的异恶唑衍生物，其中R1代表氢，低级烷基，氨基，卤素，低级烷氧基等，R2代表取代或未取代的芳基等，R3代表氢或低级烷基，R4代表 代表取代或未取代的苯基等，Y代表具有优异p38MAP激酶的-CH 2 - ， - CO - ， - CH（CH 3） - ， - O-，-NH-等或其药学上可接受的盐 抑制作用。

公开(公告)号：US20090192164A1

公开(公告)日：2009-07-30

申请号：US12308750

申请日：2007-06-26

申请人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

发明人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

IPC分类号： A61K31/4439 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  C07D403/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/53 ,  A61P1/00

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  C07D401/14 ,  C07D413/04

摘要： The invention discloses treating agents of inflammatory bowel disease, which contain p38MAPkinase inhibitor having properties of antedrug as the active ingredient.

摘要翻译： 本发明公开了含有作为活性成分的具有特性的p38MAP激酶抑制剂的炎症性肠病治疗剂。

公开(公告)号：US20090306145A1

公开(公告)日：2009-12-10

申请号：US12308875

申请日：2007-06-26

申请人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

发明人： Koichi Hasumi ,  Shuji Ohta ,  Takahisa Saito ,  Shuichiro Sato ,  Jun-ya Kato ,  Jun Sato ,  Hiroyuki Suzuki ,  Hajime Asano ,  Mami Okada ,  Yasuhiro Matsumoto ,  Kazuhiko Shirota

IPC分类号： A61K31/4439 ,  C07D413/04 ,  A61P35/00

CPC分类号： C07D413/04 ,  C07D413/14

摘要： This invention offers isoxazole derivatives represented by the following formula (I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for —CH2—, —CO—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and are useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like.

摘要翻译： 本发明提供由下式（I）表示的异恶唑衍生物，其中R 1和R 2各自代表氢，低级烷基，氨基等; R3代表取代或未取代的芳基或杂芳基; R4代表氢或低级烷基; R5代表取代或未取代的苯基，呋喃基等; Y表示具有优异的p38MAP激酶抑制作用的副产物-CH 2 - ， - CO - ， - O-，-NH-等或其药学上可接受的盐，可用于治疗慢性 类风湿性关节炎，溃疡性结肠炎等。

公开(公告)号：US5427752A

公开(公告)日：1995-06-27

申请号：US073652

申请日：1993-06-07

申请人： Mitsugi Suehiro ,  Touru Seto ,  Shigeaki Mitsuoka ,  Kenji Inoue ,  Kazuhiko Shirota

发明人： Mitsugi Suehiro ,  Touru Seto ,  Shigeaki Mitsuoka ,  Kenji Inoue ,  Kazuhiko Shirota

IPC分类号： B01D53/14 ,  B01D53/48 ,  B01D53/52 ,  C01B17/04 ,  C01B17/50 ,  C10J3/72 ,  C10K1/20 ,  C10K1/32 ,  C10K1/26 ,  C10K1/28

CPC分类号： B01D53/485 ,  B01D53/52 ,  C01B17/0408 ,  C01B17/508 ,  C10K1/20 ,  Y02P20/133

摘要： A process for purifying high-temperature reducing gases containing sulfureous contaminants including hydrogen sulfide and carbonyl sulfide with an absorbent, said process characterized in that at least three reactor towers which are filled with an absorbent are used, and said process comprises the three steps of absorption, regeneration, and reduction, and during in a part of operation two reactor towers are connected in series so as to carry out regeneration, and O.sub.2 concentration can be controlled separately for each regenerating reactor tower in the regeneration step, and steam can be supplied so as to prevent excessive reduction of the absorbent from occurring in the reduction step. The life of the absorbent can be extended and operational costs may be reduced.

摘要翻译： 一种用吸收剂净化包含硫化氢和羰基硫化物的含硫污染物的高温还原气体的方法，所述方法的特征在于，使用填充有吸收剂的至少三个反应器塔，所述方法包括三个步骤的吸收 ，再生和还原，并且在操作的一部分期间，两个反应器塔串联连接以进行再生，并且在再生步骤中可以分别对每个再生反应塔进行O2浓度控制，并且可以供应蒸汽 以防止在还原步骤中发生吸收剂的过度减少。 吸收剂的寿命可以延长，并且可以降低操作成本。