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17 条记录 (耗时 0.021 秒)

    Manufacturing method and apparatus for shell of universal-joint
    1.
    发明授权
    Manufacturing method and apparatus for shell of universal-joint 失效
    万向节外壳的制造方法和装置

    公开(公告)号：US4470288A

    公开(公告)日：1984-09-11

    申请号：US412088

    申请日：1982-08-27

    申请人： Koichi Takeda ,  Sadao Ikeda ,  Koichi Matsubara

    发明人： Koichi Takeda ,  Sadao Ikeda ,  Koichi Matsubara

    IPC分类号： B21D17/02 ,  B21D19/08 ,  B21D53/10 ,  B21D53/84 ,  F16D3/20 ,  F16D3/205 ,  B21K21/08

    CPC分类号： B21D17/02 ,  B21D19/08 ,  B21D53/10 ,  B21D53/84 ,  Y10S72/714

    摘要： Manufacturing method for a tubular shell of a constant velocity universal-joint for flexibly coupling two rotary shafts, to one of which the shell is fixed at a flange thereof. The method comprises a groove and preliminary flange forming process and a flange forming process. In the former process a hollow cylindrical blank is applied pressing in a radial direction for forming plural grooves therein and forming at the same time a preliminary flange at one end of the cylindrical blank by expanding it into a funnel shape, and in the latter process the preliminary flange formed on a semi-finished article in the former process is formed into a completed flange by a flange forming die, while holding the semi-finished article in a restrained status under pressure from either side, external and internal, by means of restraining dies. An apparatus suitable for performing the method is also disclosed.

    摘要翻译： 用于柔性地联接两个旋转轴的等速万向接头的管状壳体的制造方法，其中一个壳体固定在其凸缘上。 该方法包括凹槽和预凸缘形成工艺和凸缘成形工艺。 在前一种方法中，中空圆柱形坯料沿径向施加压力以在其中形成多个凹槽，同时通过将圆筒形坯料的一端扩展成漏斗形状同时形成预备凸缘，在后一过程中 在前一工艺中形成在半成品上的初步凸缘通过凸缘成形模具形成为完整的凸缘，同时通过约束从两侧，外部和内部的压力将半成品保持在约束状态 死了 还公开了一种适于执行该方法的装置。

    Shell of a universal-joint and a manufacturing method therefor
    2.
    发明授权
    Shell of a universal-joint and a manufacturing method therefor 失效
    万向节壳及其制造方法

    公开(公告)号：US4453395A

    公开(公告)日：1984-06-12

    申请号：US342010

    申请日：1982-01-15

    申请人： Koichi Takeda ,  Sadao Ikeda ,  Koichi Matsubara

    发明人： Koichi Takeda ,  Sadao Ikeda ,  Koichi Matsubara

    IPC分类号： B21D53/10 ,  B21D53/84 ,  F16D3/20 ,  F16D3/205 ,  B21D51/16

    CPC分类号： B21K1/765 ,  B21D53/84 ,  F16D3/2055 ,  Y10S72/714

    摘要： A shell for a universal joint for flexibly coupling two rotary shafts. The shell is constructed using a manufacturing technique to produce a shell of light weight and excellent strength. The shell generally has a hollow cylindrical configuration and is secured at one end to a rotary shaft and formed to have a plurality of grooves extending parallel to its cylindrical axis. A second rotary shaft includes portions which engage the plurality of grooves for transmitting movement from one shaft to the other through the shell. The shell may be formed using a tubular work piece or a planar work piece, and may be provided in substantially complete form by use of a machine press prior to subjecting the material to an ironing process to make the grooves of accurate shape and dimension. The process is performed such that no machining is required to form the grooves and produce the shell.

    摘要翻译： PCT No.PCT / JP81 / 00079 Sec。 371日期1982年1月15日 102（e）日期1982年1月15日PCT提交1981年4月7日PCT公布。 出版物WO81 / 03294 日期：1981年11月26日。一种用于柔性联接两个旋转轴的万向节的外壳。 外壳采用制造技术制造，制造重量轻，强度优良的外壳。 壳体通常具有中空圆柱形构造并且在一端固定到旋转轴并且形成为具有平行于其圆柱轴线延伸的多个凹槽。 第二旋转轴包括接合多个槽的部分，用于将运动通过壳体从一个轴传递到另一个轴。 壳可以使用管状工件或平面工件形成，并且可以在使材料经受熨烫过程以使凹槽具有精确的形状和尺寸之前通过使用机器压机以基本上完​​整的形式提供。 执行该过程，使得不需要加工来形成凹槽并产生壳体。

    CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF
    3.
    发明申请
    CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF 审中-公开
    癌症干细胞质量及其生产方法

    公开(公告)号：US20130288248A1

    公开(公告)日：2013-10-31

    申请号：US13878181

    申请日：2011-10-06

    申请人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Yu Jau Chen ,  Atsuhiko Kato ,  Masami Suzuki ,  Koichi Matsubara

    发明人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Yu Jau Chen ,  Atsuhiko Kato ,  Masami Suzuki ,  Koichi Matsubara

    IPC分类号： C12N5/095

    CPC分类号： C12N5/0695 ,  G01N33/5011 ,  G01N33/5073

    摘要： The purpose of the present invention is to provide: a cancer stem cell mass from which cells incapable of forming cancer are substantially removed and which has a characteristic property of reproducing a layered structure of a cancer tissue; a process for producing the cancer stem cell mass; and use of the cancer stem cell mass. For achieving the purpose, the present inventors grew a human cancer tissue repeatedly in a NOG mouse, separated cancer cells from the grown cancer tissue, and made a comparison of various cancer cell culture processes with each other. As a result, a cancer stem cell composition which is homogeneous and is substantially free of the coexistence of cells capable of forming cancer and cells incapable of forming cancer in a mixed state can be produced successively by employing an attached culture process using a serum-free stem cell culture medium rather than a generally employed floating culture process, and consequently the present invention has been accomplished.

    摘要翻译： 本发明的目的是提供：基本上除去不能形成癌症的细胞的癌干细胞群，其具有再现癌组织的层状结构的特征; 一种生产癌症干细胞团的方法; 并使用癌干细胞团。 为了达到上述目的，本发明人在NOG小鼠中反复生长人类癌组织，从生长的癌组织中分离癌细胞，并进行各种癌细胞培养方法的比较。 结果，可以通过使用不含血清的附着培养方法，连续地制备均质且基本上不含可形成癌细胞的细胞和不能混合形成癌症的细胞的癌干细胞组合物 干细胞培养基而不是通常使用的浮动培养方法，因此本发明已经实现。

    Image processing apparatus, image forming apparatus, image processing method, and computer-readable medium
    5.
    发明授权
    Image processing apparatus, image forming apparatus, image processing method, and computer-readable medium 有权
    图像处理装置，图像形成装置，图像处理方法以及计算机可读介质

    公开(公告)号：US08724174B2

    公开(公告)日：2014-05-13

    申请号：US13361474

    申请日：2012-01-30

    申请人： Toru Misaizu ,  Kenji Hara ,  Shigeru Arai ,  Koichi Matsubara ,  Kouta Matsuo

    发明人： Toru Misaizu ,  Kenji Hara ,  Shigeru Arai ,  Koichi Matsubara ,  Kouta Matsuo

    IPC分类号： G06K1/00 ,  G06F15/00 ,  H04N1/46

    CPC分类号： H04N1/4072

    摘要： An image processing apparatus includes an edge-portion detector, an edge-width detector, and a tone correction unit. The edge-portion detector detects a pixel of an edge portion by determining whether or not each of pixels constituting image data which has been input is a pixel which is included in the edge portion. The edge-width detector detects, for the pixel of the edge portion detected by the edge-portion detector, an edge width which is a width of the edge portion. When the edge width detected by the edge-width detector is smaller than a value which is set in advance, the tone correction unit performs tone correction differently in accordance with the detected edge width.

    摘要翻译： 图像处理装置包括边缘部分检测器，边缘宽度检测器和色调校正单元。 边缘部分检测器通过确定构成已经输入的图像数据的每个像素是否包括在边缘部分中的像素来检测边缘部分的像素。 对于由边缘部分检测器检测的边缘部分的像素，边缘宽度检测器检测作为边缘部分的宽度的边缘宽度。 当由边缘检测器检测到的边缘宽度小于预先设置的值时，色调校正单元根据检测到的边缘宽度进行不同的色调校正。

    Method of Proliferating Plasma Cells
    6.
    发明申请
    Method of Proliferating Plasma Cells 失效
    增殖血浆细胞的方法

    公开(公告)号：US20120015402A1

    公开(公告)日：2012-01-19

    申请号：US13187677

    申请日：2011-07-21

    申请人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    发明人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    IPC分类号： C12P21/00 ,  C12N5/071

    CPC分类号： A01K67/027 ,  A01K2267/01 ,  A61K35/16 ,  C07K16/00 ,  C07K16/30

    摘要： An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.

    摘要翻译： 本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率 作为从抗体产生细胞编码它们的核酸。 本发明人发现，当将包含浸润性淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖 并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。